Gastroesophageal reflux disease: clinical, endoscopic, and intraluminal esophageal pH monitoring evaluation

Nasi, Ary; Filho, J. P. P. Moraes; Zilberstein, Bruno; Ivan, Cristina; Gama-Rodrigues, Joaquim; Pinotti, H W

doi:10.1111/j.1442-2050.2001.00130.x

Cited by 21 publications

(32 citation statements)

References 26 publications

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“…is considered one of the most prevalent digestive diseases in Western countries 12 . It occurs as a result of exposure of esophageal or supra-esophageal mucosa to the intragastric content, containing harmful agents such as hydrochloric acid, pepsin, bile salts and pancreatic enzymes 11 .…”

Section: G Astroesophageal Reflux Disease (Gerd)mentioning

confidence: 99%

O esôfago curto e o refluxo distal são fatores de risco para o refluxo proximal?

Serra

Gandolfi

Pratesi

2010

ABCD, arq. bras. cir. dig.

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Section: G Astroesophageal Reflux Disease (Gerd)mentioning

confidence: 99%

O esôfago curto e o refluxo distal são fatores de risco para o refluxo proximal?

Serra

Gandolfi

Pratesi

2010

ABCD, arq. bras. cir. dig.

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“…Untreated or improperly treated GERD can, in cases of chronic disease, lead to serious complications, including Barrett's esophagus and esophageal adenocarcinoma (3).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Protective Effect of Brassica oleracea (L. var. acephala) in Rats with Surgically-Induced Gastroesophageal Reflux Disease

Wisnieski

Brito

Cosenza

et al. 2016

Thrita

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Background: Gastroesophageal reflux disease (GERD) is a common disorder that may result in esophageal cancer. Although proton pump inhibitors are the standard treatment for this illness, Brassica oleracea may provide new therapeutic possibilities. Objectives: We aimed to evaluate and compare the effects of the B. oleracea extract and the proton pump inhibitor omeprazole on esophageal complications arising from a surgically-induced GERD model in rats. In addition, we investigated possible associations between the frequency of DNA damage and esophageal histological alterations, as well as the genotoxic/anti-genotoxic and cytotoxic/anti-cytotoxic effects of B. oleracea and omeprazole. Methods: Rats with and without GERD were equally divided into groups to receive one of two the treatments, B. oleracea extract (500 mg/kg bw) or omeprazole (30 mg/kg bw), daily over the course of four weeks. A group of non-treated rats received water in the same circumstances. Micronucleus assay was used to assess DNA damage in blood and bone marrow cells. Results: Rats with GERD developed esophagitis and esophageal squamous cell carcinoma. B. oleracea and omeprazole-treated GERD rats presented significantly decreased inflammation in relation to non-treated GERD rats (P < 0.05). However, in rats without GERD, omeprazole significantly increased the frequencies of micronuclei and micronucleated cells as compared to the corresponding cell counts in non-treated rats (P = 0.04). Conclusions: B. oleracea demonstrated similar anti-inflammatory properties to omeprazole in rats with GERD. However, omeprazole also demonstrated genotoxic and cytotoxic effects in rats without GERD.

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“…Normal values of esophageal pH monitoring, in patients with endoscopic esophagitis, ranges from 17% to 31.4% (3,5,14,15,17,21,22,28) . As a result, a normal pH monitoring does not exclude GERD diagnosis (3) .…”

Section: Introductionmentioning

confidence: 99%

Comparative study of two modes of gastroesophageal reflux measuring: conventional esophageal pH monitoring and wireless pH monitoring

Azzam¹,

Sallum²,

Brandão³

et al. 2012

Arq. Gastroenterol.

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CONTEXT: Esophageal pH monitoring is considered to be the gold standard for the diagnosis of gastroesophageal acid reflux. However, this method is very troublesome and considerably limits the patient's routine activities. Wireless pH monitoring was developed to avoid these restrictions. OBJECTIVE: To compare the first 24 hours of the conventional and wireless pH monitoring, positioned 3 cm above the lower esophageal sphincter, in relation to: the occurrence of relevant technical failures, the ability to detect reflux and the ability to correlate the clinical symptoms to reflux. METHODS: Twenty-five patients referred for esophageal pH monitoring and with typical symptoms of gastroesophageal reflux disease were studied prospectively, underwent clinical interview, endoscopy, esophageal manometry and were submitted, with a simultaneous initial period, to 24-hour catheter pH monitoring and 48-hour wireless pH monitoring. RESULTS: Early capsule detachment occurred in one (4%) case and there were no technical failures with the catheter pH monitoring (P = 0.463). Percentages of reflux time (total, upright and supine) were higher with the wireless pH monitoring (P < 0.05). Pathological gastroesophageal reflux occurred in 16 (64%) patients submitted to catheter and in 19 (76%) to the capsule (P = 0.355). The symptom index was positive in 12 (48%) patients with catheter pH monitoring and in 13 (52%) with wireless pH monitoring (P = 0.777). CONCLUSIONS: 1) No significant differences were reported between the two methods of pH monitoring (capsule vs catheter), in regard to relevant technical failures; 2) Wireless pH monitoring detected higher percentages of reflux time than the conventional pH-metry; 3) The two methods of pH monitoring were comparable in diagnosis of pathological gastroesophageal reflux and comparable in correlating the clinical symptoms with the gastroesophageal reflux.

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Gastroesophageal reflux disease: clinical, endoscopic, and intraluminal esophageal pH monitoring evaluation

Cited by 21 publications

References 26 publications

O esôfago curto e o refluxo distal são fatores de risco para o refluxo proximal?

O esôfago curto e o refluxo distal são fatores de risco para o refluxo proximal?

Evaluation of the Protective Effect of Brassica oleracea (L. var. acephala) in Rats with Surgically-Induced Gastroesophageal Reflux Disease

Comparative study of two modes of gastroesophageal reflux measuring: conventional esophageal pH monitoring and wireless pH monitoring

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