Gastrointestinal actions of garlic oil

Joshi, D. J.; Dikshit, R K; Mansuri, Sohil

doi:10.1002/ptr.2650010309

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…Garlic has been shown to affect the physiology of the gastrointestinal tract. It decreases episodes of diarrhoea by relaxing smooth muscle to decrease peristaltic action (Joshi et al, 1987). This may also indicate a role for NO, the effector of smooth muscle relaxation.…”

Section: Discussionmentioning

confidence: 97%

The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial

et al. 2000

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Whole garlic (Allium sativum L.) extract and some of its components were assayed for antigiardial activity. Whole garlic extract gave an IC 50 at 24 h of 03 mg ml N1 . Most of the components assayed were inhibitory to the organism, especially allyl alcohol and allyl mercaptan, with IC 50 values of 7 µg ml N1 and 37 µg ml N1 respectively. Studies with calcofluor white indicated that whole garlic and allyl alcohol collapse the transmembrane electrochemical membrane potential (∆ψ) of the organism, as indicated by uptake of the fluorochrome. Electron microscopy allowed the morphological changes that occur with garlic inhibition to be recorded. Both the surface topography and internal architecture of the organism changed during incubation with the biocides. Both whole garlic and allyl alcohol resulted in fragmentation of the disc and an overexpression of disc microribbons, internalization of flagella, vacuole formation and an increase in distended vesicles. Allyl mercaptan, however, only gave an increase in distended vesicles, suggesting that this biocide has a different mode of action.

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Section: Discussionmentioning

confidence: 97%