Antidiarrhoeal activity of root extracts from Roureopsis obliquifoliolata and Epinetrum villosum

Otshudi, A Longanga; Vercruysse, Antoine; Foriers, André

doi:10.1016/s0367-326x(00)00292-6

Cited by 14 publications

(4 citation statements)

References 2 publications

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“…The aim of the present study was to evaluate the antidiarrhoeal effects of the leaves of M.malabathricum , which are consumed very commonly by the Jah hut people in Malaysia, to treat the diarrhea. In establishing the pharmacological evaluation of a potential antidiarrhoeal agent, the inhibition of experimentally induced diarrhea, reduction in the fecal output and gastrointestinal motility tests have remained the most common parameters in several studies[15–17]. The present study revealed that the water extract of M. malabathricum leaves inhibited significantly the frequency of defecation and reduced greatly the wetness of the fecal excretion like the standard antidiarrhoeal agent, loperamide.…”

mentioning

confidence: 52%

Antidiarrhoeal activity of leaves ofMelastoma malabathricumlinn

Sunilson¹,

Anandarajagopal²,

Kumari³

et al. 2009

Indian J Pharm Sci

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The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.

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mentioning

confidence: 52%

Antidiarrhoeal activity of leaves ofMelastoma malabathricumlinn

Sunilson¹,

Anandarajagopal²,

Kumari³

et al. 2009

Indian J Pharm Sci

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“…Several national and international organization assists in conducting studies for curing diarrheal ailments by conventional approaches (Tona et al 1998;Lin et al 2002). It provides an effective source of medicine for diarrheal diseases (Mukherjee et al 1998;Otshudi et al 2001;Patel et al 2008;Njume & Goduka 2012). A similar positive relationship between diarrhea and temperature has been reported in Latin America and Africa (Thiam et al 2017).…”

Section: Introductionmentioning

confidence: 79%

Treatment of diarrhea and dysentery through ethnomedicinal plants in the Jaunpur Region of Garhwal Himalaya, India

Lal,

Dangwal,

Rawat

2024

Ethnobot. Res. App.

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Background: Diarrhea and dysentery are leading causes of death and illness in rural areas of developing countries in worldwide and neighboring countries. Diarrhea ranking as the third most common cause of child mortality in India. It contributes to 13% of deaths in children under five years annually. Even at the present time, majority of the rural people of the country still rely on regional plants resources to treat many diseases, including diarrhea and dysentery. The aim of the present study was to document and record the utilization of ethnomedicinal plants and various herbal remedies for the management of gastrointestinal ailments, with a specific focus on combating diarrhea and dysentery in the rural area of Garhwal Himalaya, specifically the Jaunpur region in the study site.Methods: Ethnobotanical investigation was carried out in 12 villages (namely Dhanaulti, Rautu ki Beli, Nainbagh, Kempty, Thatyur, Almas, Kyari, Pantwari, Devalsari, Teva, Naag Tibba, and Ontal) with traditional practices, interviewing 138 local informants (90 males and 48 females). The various methods (group discussions, meetings, and questionnaires) to gather ethnomedicinal knowledge for curing diarrhea and dysentery treatment. Furthermore, in this study, the informant's consensus factor (ICF), use value (UV), and fidelity index (FI%) were also discussed for each of the studied species.Results: In this study, local informants utilized a total of 30 ethnomedicinal plant species (from 28 genera and 30 families) to treat diarrhea and dysentery. The percentage of plant species used for specific ailments was: diarrhea (32% spp.), dysentery (20%), digestive problems (14%), stomach problems (12%), gastroenteritis (8%), appetizers (6%), dyspepsia (4%), oral ulcers (2%), and flatulence (2%). The residents use specific plant parts for ethnomedicinal purposes, with the following distribution: bark (3% spp.), fruits (10%), flowers (3%), leaves (45%), rhizomes (7%), roots (13%), seeds (3%), stems (7%), twigs (3%), and whole plant (6%). The herbal preparations in use include decoction (56% spp.), infusion (20%), juice (12%), paste (8%), and powder (4%). Conclusion:The present communication provides valuable insights into the indigenous utilization and availability of ethnomedicinal plants for treating diarrhea and dysentery. It underscores the importance of documenting and preserving this rich reservoir of knowledge passed down through generations for future research endeavors.

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“…Secondary metabolites of plants such as terpenoids, sterols, flavonoids, phenolic compounds, tannins and alkaloids [18] have been previously found to be responsible for laxative activities in plants. These constituents that have been reported by Okokon and Nwafor [2] to be present in the root extract of C. zambesicus maybe responsible for the laxative activity of the extract.…”

Section: Discussionmentioning

confidence: 99%

Croton zambesicus Root Extract Exert Laxative Effect in Rats

Okokon

Bassey

Nyong

et al. 2020

AJOB

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Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments. Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT). Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT. Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied. Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.

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Antidiarrhoeal activity of root extracts from Roureopsis obliquifoliolata and Epinetrum villosum

Cited by 14 publications

References 2 publications

Antidiarrhoeal activity of leaves ofMelastoma malabathricumlinn

Antidiarrhoeal activity of leaves ofMelastoma malabathricumlinn

Treatment of diarrhea and dysentery through ethnomedicinal plants in the Jaunpur Region of Garhwal Himalaya, India

Croton zambesicus Root Extract Exert Laxative Effect in Rats

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