Gastrointestinal angiodysplasia: A possible component of von Willebrand's disease

Bleeding in continuous flow left ventricular assist device recipients: an acquired vasculopathy?

“…Whether a selective decrease of the HMWMs of vWF as seen in CF LVAD subjects can cause a similar effect is unknown and warrants investigation. It is also important to note that 10% of patients with congenital vWD develop AVMs (24,25). When considered together, these are intriguing findings and, contrary to the proposed paradigm, may imply that vWD is not only the second hit but also causal in AVM formation.…”

Small Bowel Angiodysplasia Associated with von Willebrand's Disease: Report of a Case

“…The clinical course of patients with vWD and AD is characterized by multiple admissions to hospital for gastrointestinal bleeding, which requires the transfusion of packed red cells and FVIII-vWF concentrates. 7 An extensive review of the literature by Duray et al 8 in 1984 revealed only three cases of AD of the small bowel in association with vWD. Our search of the literature revealed another five cases of vWD and AD in the small bowel reported from 2000 until now (Table 1).…”

Hepatic artery pseudoaneurysm in von Willebrand's disease

“…The vascular abnormalities in vWD are very interesting since it is known that von Willebrand's factor is synthesized by endothelial cells [8]. Evidence from literature suggests the hypothesis that vWD may be a part of a large syndrome encompassing structural and functional mesenchymaderived structures such as bone, cardiac valves and blood vessels [6,7,8]. Pseudoaneurysms of the hepatic artery are rare and are usually related to abdominal surgery, intra-abdominal inflammation or penetrating abdominal trauma.…”

“…These conditions include arterial aneurysms [1], pseudoaneurysms [2,3,4], intracranial arteriovenous malformations [5], mitral valve prolapse [6], gastrointestinal angiodysplasias [7] and telangiectasias [8]. We present a case of a giant hepatic artery pseudoaneurysm in a patient with vWD which has been successfully treated by coil embolization.…”