Gastrointestinal basidiobolomycosis: Beware of the great masquerade a case report

Balkhair, Abdullah; Wahaibi, A. Al; Al-Qadhi, Hani; Al-Harthy, Ahmed; Lakhtakia, Ritu; Rasool, W.; Ibrahim, S.

doi:10.1016/j.idcr.2019.e00614

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…The Patient’s general symptoms like abdominal pain, anorexia, constipation, and weight loss were similar to other reported cases but the patient had no bleeding although GI bleeding does not show a predilection for any particular age group and has been reported in patients aged 1.5 years to 80 years in most of the cases [ 12 – 14 ]. The colonoscopy in our case was mostly normal.…”

Section: Discussionsupporting

confidence: 81%

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Colonic basidiobolomycosis in a patient with systemic lupus erythematosus (SLE)

et al. 2022

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Background Basidiobolus ranarum belongs to the Entomophthorales order and the Zygomycetes class. This fungus is an environmental saprophyte that can be found in soil and rotting vegetables.Primarily restricted to tropical regions including Asia, Africa, and South America. It might cause chronic inflammatory diseases, mostly affect subcutaneous tissue. Systemic infections involving the gastrointestinal tract are extremely rare. Case presentation Herein, we present a 44-year-old Persian man with the past medical history of lupus erythematosus with colicky abdominal pain started from three months before admission with many vomiting episodes, and a mass on the right lower quadrant, who had been thought initially to have an abdominal malignancy. The patient had vital signs were within normal ranges. His physical examination revealed tenderness and rebound tenderness on the right lower quadrant of the abdomen. A fixed mass 10 × 10 centimeter in diameter was palpated in the same quadrant. Laboratory, radiologic, colonoscopic examination was requested. The patient underwent laparotomy which revealed a mass in the terminal ileum and ascending colon with retroperitoneal adhesion and invasion to the right ureter behind it. Pathologic examination showed basidiobolomycosis infection in the specimen. Conclusion Fungal infection should be among the differential diagnoses for adults present with abdominal mass in endemic regions of the world.

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Section: Discussionsupporting

confidence: 81%

“…The stomach, small intestines, colon, and liver are among the major organs that can be affected [ 12 , 13 ]. Nonspecific signs and symptoms make diagnosis difficult [ 14 ]. A prompt and accurate diagnosis is critical, especially when there are signs of obstruction or sepsis.…”

Section: Discussionmentioning

confidence: 99%

Colonic basidiobolomycosis in a patient with systemic lupus erythematosus (SLE)

et al. 2022

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“…Colonic involvement in gastrointestinal basidiobolomycosis is commonly misdiagnosed as malignant mass commonly in the cecal or ascending colon with local invasion and, at times, involvement of distant sites [ 8 , 16 ]. Disseminated gastrointestinal basidiobolomycosis is rare but potentially fatal [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The condition is most commonly diagnosed post-surgery and after the analysis of the resected tissues. So, the final diagnosis frequently comes late in the disease course [ 8 , 16 ]. As a result, gastrointestinal basidiobolomycosis should be kept in the differential diagnosis of inflammatory diseases of the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

A Pediatric Case of Basidiobolomycosis Presenting With an Abdominal Mass

Shaaban¹,

Almatrafi²,

Telmesani³

2022

Cureus

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Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum. The condition has been reported in children and adults presenting with abdominal pain, weight loss, abdominal distension, vomiting, diarrhea, fever, and an abdominal mass. We report a case of a previously healthy 2.5 years old male who presented to the ER complaining of abdominal pain and distension for two weeks together with significant weight loss. He looked ill and cachectic. He had tachycardia but was afebrile. His abdominal examination showed a right-sided abdominal mass. His initial abdominal ultrasound (US) suggested an abdominal tumor. The patient was referred to a tertiary center where he had an ultrasound-guided biopsy that showed fungal hyphae consistent with basidiobolomycosis.

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“…Detailed examination of the thrombus and a section of the small intestine of our patient showed thin-walled, broad and septate hyphae, and these features are compatible with zygomycete-like fungi ( Figure 3 ). Diagnosis of Basidiobolus infection down to the species level is typically accomplished by microbiological culture as gold standard [ 44 ]. From the thrombus specimen that was extracted from the common femoral artery, and from a urine sample, a mould was grown reminiscent of a Basidiobolus species.…”

Section: Discussionmentioning

confidence: 99%

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Al‐Hatmi

Balkhair

Al-Busaidi

et al. 2021

JoF

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Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.

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Gastrointestinal basidiobolomycosis: Beware of the great masquerade a case report

Cited by 9 publications

References 14 publications

Colonic basidiobolomycosis in a patient with systemic lupus erythematosus (SLE)

Colonic basidiobolomycosis in a patient with systemic lupus erythematosus (SLE)

A Pediatric Case of Basidiobolomycosis Presenting With an Abdominal Mass

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

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