Gastrointestinal digestion of food-use silver nanoparticles in the dynamic SIMulator of the GastroIntestinal tract (simgi®). Impact on human gut microbiota

Cueva, Carolina; Gil‐Sánchez, Irene; Tamargo, Alba; Miralles, Beatriz; Crespo, Julián; Bartolomé, Begoña; Moreno‐Arribas, M. Victoria

doi:10.1016/j.fct.2019.110657

Cited by 51 publications

(34 citation statements)

References 45 publications

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“…A) A photograph of the SHIME model developed by ProDigest and adopted at Wageningen University . B) The SIMGI gastrointestinal in vitro model 128b,129. Photo of the entire setup comprising 1) the stomach with peristalsis action; 2) the small intestine; 3) ascending; 4) transverse and 5) descending colon; 6) pH, nitrogen, and temperature controllers, and 7) water bath.…”

Section: In Vitro Macromodelsmentioning

confidence: 99%

Section: In Vitro Macromodelsmentioning

confidence: 99%

“…Copyright 2019, Elsevier. The detailed picture of the small intestine compartment (zoom) was kindly provided by Alba Tamargo and colleagues from the Institute of Food Science Research (CIAL), Spain 128b,129. C,D) Photographs from left to right showing in order the TIM‐1 and Tiny‐TIM.…”

Section: In Vitro Macromodelsmentioning

confidence: 99%

“…SIMGI has been used for studying the effect of various food ingredients and evaluate their modulation effect on the gut microbiota such as grape pomace extracts 128b–d. More recently, SIMGI was employed to study the antimicrobial effects of silver nanoparticles, which may function as food additives . In this study, the authors tested multiple types of particles for their effects on the metabolic activity and on gut microbiota, and revealed that all particles increased Lactobacillus numbers.…”

Section: In Vitro Macromodelsmentioning

confidence: 99%

“…Copyright 2010, The Royal Society. The macro‐models image was provided by Alba Tamargo and colleagues (Institute of Food Science Research (CIAL), Spain) 128b,129. The first in vitro micro‐models image is reproduced with permission under the terms of the Creative Commons CC BY licence 4.0 .…”

Section: Introductionmentioning

confidence: 99%

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Models of the Gut for Analyzing the Impact of Food and Drugs

Fois

Schindeler

et al. 2019

Adv Healthcare Materials

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The human intestine is the primary organ responsible for the uptake of nutrients and water, and this is facilitated by its complex structure that features a large surface area. With an average total length of around seven meters, including both small and large intestine, it connects the stomach to the rectum while enabling absorption in a specialized manner. At a cellular level, the gut epithelium is critical in selective transport to the bloodstream. The finger-like projections of the intestinal epithelium Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.

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Section: In Vitro Macromodelsmentioning

confidence: 99%

Section: In Vitro Macromodelsmentioning

confidence: 99%

Section: In Vitro Macromodelsmentioning

confidence: 99%

Section: In Vitro Macromodelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Models of the Gut for Analyzing the Impact of Food and Drugs

Fois

Schindeler

et al. 2019

Adv Healthcare Materials

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Neurobehavior and neuron damage following prolonged exposure of silver nanoparticles with/without polyvinylpyrrolidone coating in Caenorhabditis elegans

Zhang

et al. 2021

J of Applied Toxicology

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Silver nanoparticles (AgNPs) have become widespread in the environment with increasing industrial applications. But the studies about their potential health risks are far from enough, especially in neurotoxic effects. This study aimed to investigate the neurotoxic effects of longer‐term exposure (prolonged exposure for 48 h and chronic exposure for 6 days) of 20nm AgNPs with/without polyvinylpyrrolidone (PVP) coating at low concentrations (0.01–10 mg·L−1) to Caenorhabditis elegans. The results suggested that exposure to AgNPs induced damage to nematode survival, with the longest and relative average life span reduced. Exposure to AgNPs caused neurotoxicity on locomotion behaviors (head thrashes, body bends, pharyngeal pumping frequency, and defecation interval) and sensory perception behaviors (chemotaxis assay and thermotaxis assay), as well as impaired dopaminergic, GABAergic, and cholinergic neurons, except for glutamatergic, based on the alters fluorescence intensity, in a dose‐ and time‐dependent manner. Further investigations suggested that the low‐dose AgNPs (0.01–0.1 mg·L−1) exposure raises receptors of GABAergic and dopamine in C. elegans at the genetic level, whereas opposite results were observed at higher doses (1–10 mg·L−1), which implied that AgNPs could cause neurotoxicity by impairing neurotransmitter delivery. The PVP‐AgNPs could cause a higher fatality rate and neurotoxicity at the same dose. Notably, AgNPs did not cause any deleterious effect on nematodes at the lowest dose of 0.01 mg·L−1. In general, these results suggested that AgNPs possess the neurotoxic potential in C. elegans and provided useful information to understand the neurotoxicity of AgNPs, which would offer an inspiring perspective on the safe application.

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