Gastrointestinal disturbances in diabetes

Chandran, Manju; Chu, Neelima V.; Edelman, Steven V.

doi:10.1007/s11892-003-0052-7

Cited by 20 publications

(12 citation statements)

References 39 publications

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“…GI symptoms are relatively common in clinical practice in patients with type II DM 1. In the present study, the proportion of patients experiencing at least weekly typical GERD symptoms in type II DM was 23.1%, which seems to be far higher than the reported prevalence of GERD from the general Korean population 16,17…”

Section: Discussioncontrasting

confidence: 48%

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Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy

Lee¹,

Keum²,

Chun³

et al. 2011

J Neurogastroenterol Motil

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Background/AimsPatients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD). Recent studies have shown that neuropathy has positive role on the development of GERD in type II DM, although its pathogenesis has not been fully understood yet. The aim of this study was to investigate whether neuropathy really contribute to the development of GERD and typical GERD symptoms in patients with type II DM in Korea.MethodsOne hundred and nineteen patients with type II DM who had given informed consents were enrolled. All patients underwent electromyography to check the presence of peripheral neuropathy, face-to-face interview to evaluate their typical GERD symptoms and esophagogastroduodenoscopy to look for the presence of erosive esophagitis. Ninety-five patients were finally included for this study and they were divided according to the presence or absence of the peripheral neuropathy.ResultsThe mean age of 95 patients was 59.3 ± 9.1 years and the mean disease duration of DM was 9.3 ± 5.9 years. Typical GERD symptoms were similarly found in both groups with and without peripheral neuropathy (23.6% vs 22.8%, P = 0.921). Erosive esophagitis was more prevalent in patients with neuropathy than in those without neuropathy (31.5% vs 10.5%, P = 0.022).ConclusionsIn patients with type II DM, peripheral neuropathy is an independent risk factor for the erosive esophagitis. However, peripheral neuropathy did not contribute to the presence of the typical GERD symptoms.

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Section: Discussioncontrasting

confidence: 48%

“…Up to 75% of patients with diabetes mellitus (DM) are known to experience gastrointestinal (GI) symptoms in clinical practice 1. However, the exact prevalence of gastroesophageal reflux disease (GERD) in patients with DM has been on debate.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy

Lee¹,

Keum²,

Chun³

et al. 2011

J Neurogastroenterol Motil

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“…The complications of DM like neuropathy, retinopathy, nephropathy and gastroparesis [38,39] could also contribute to the potential risk of developing adverse drug reactions to TB treatment [40]. For example, a patient with neuropathy might be a potential candidate to develop isoniazid induced peripheral neuropathy due to drug-disease interaction.…”

Section: Discussionmentioning

confidence: 99%

“…For example, a patient with neuropathy might be a potential candidate to develop isoniazid induced peripheral neuropathy due to drug-disease interaction. Vomiting is one of the adverse effects of TB medications [41] and at the same time it could also be triggered due to gastroparesis [39]. Therefore, the adverse effects that these patients experienced could be attributed to either the side effects of the drugs or complications related to DM.…”

Section: Discussionmentioning

confidence: 99%

Convergence of tuberculosis and diabetes mellitus: time to individualise pharmaceutical care

et al. 2011

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“…Based on studies with radio-opaque markers, there is evidence for a generalized slowing in transit constipation in the diabetic population [14]. However, there does not appear to be a difference between subjects with and without autonomic neuropathy [15]. …”

Section: Epidemiology Clinical Presentation and Diagnosismentioning

confidence: 99%

A Practical Approach to Gastrointestinal Complications of Diabetes

Maisey

2016

Diabetes Ther

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Gastrointestinal symptoms occur frequently among people with diabetes mellitus and are associated with considerable morbidity. Enteropathy, or large bowel dysfunction, includes constipation, diarrhea and fecal incontinence, and is particularly disturbing for many patients. The pathogenesis of diabetic enteropathy is complex, primarily related to gastrointestinal autonomic dysfunction and etiologically associated with chronic hyperglycemia and diabetes duration. Since there are many other non-iatrogenic and iatrogenic causes of the cardinal symptoms of large bowel dysfunction, patients suspected of having diabetic enteropathy require detailed evaluation. The management of patients with diabetic enteropathy is challenging, and often requires a multidisciplinary approach focusing on a combination of symptom mitigation and glycemic control.

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Gastrointestinal disturbances in diabetes

Cited by 20 publications

References 39 publications

Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy

Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy

Convergence of tuberculosis and diabetes mellitus: time to individualise pharmaceutical care

A Practical Approach to Gastrointestinal Complications of Diabetes

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