Gastrointestinal Infections

Isolauri, Erika; Arvilommi, Heikki; Salminen, Seppo

doi:10.1007/978-94-017-1079-4_17

Cited by 6 publications

(1 citation statement)

References 39 publications

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“…Sudo et al (1997) demonstrated that the gut micro¯ora contributes towards generation of T-helper cells which induce oral tolerance, and this has led to the possibility of using probiotic strains as therapeutic agents in hypersensitive disorders. Lactobacilli and bi®dobacteria have a natural association with the gut mucosa and are able to promote normalisation of the increased intestinal permeability that occurs during exposure to food allergens (Isolauri et al 1999a). In addition, probiotic strains are capable of reducing the production of interleukin (IL)-4 during casein fermentation, excess production of IL-4 being one of the key features of atopic patients and responsible for initial sensitisation (Su Ètas et al 1996).…”

Section: Probioticsmentioning

confidence: 99%

Perspectives on the role of the human gut microbiota and its modulation by pro- and prebiotics

et al. 2000

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One of the most topical areas of human nutrition is the role of the gut in health and disease. Specifically, this involves interactions between the resident microbiota and dietary ingredients that support their activities. Currently, it is accepted that the gut microflora contains pathogenic, benign and beneficial components. Some microbially induced disease states such as acute gastroenteritis and pseudomembranous colitis have a defined aetiological agent(s). Speculation on the role of microbiota components in disorders such as irritable bowel syndrome, bowel cancer, neonatal necrotising enterocolitis and ulcerative colitis are less well defined, but many studies are convincing. It is evident that the gut microflora composition can be altered through diet. Because of their perceived health-promoting status, bifidobacteria and lactobacilli are the commonest targets. Probiotics involve the use of live micro-organisms in food; prebiotics are carbohydrates selectively metabolized by desirable moieties of the indigenous flora; synbiotics combine the two approaches. Dietary intervention of the human gut microbiota is feasible and has been proven as efficacious in volunteer trials. The health bonuses of such approaches offer the potential to manage many gut disorders prophylactically. However, it is imperative that the best methodologies available are applied to this area of nutritional sciences. This will undoubtedly involve a genomic application to the research and is already under way through molecular tracking of microbiota changes to diet in controlled human trials.

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Section: Probioticsmentioning

confidence: 99%