Gastrointestinal lymphoma

Thomas, Charles R.; Share, R.

doi:10.1002/mpo.2950190109

Cited by 8 publications

(5 citation statements)

References 115 publications

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“…Combined chemotherapy comprising cyclophosphamide, doxurubicin, vincristine and prednisolone (CHOP), has been the preferable and the most effective regimen for all tumor stages [31,65] . Several other regimens have also been used with almost similar efficacy and comparable toxicity [75] . While cyclophoshamide, vincristine and prednisolone (COP) were adopted for low grade lymphomas, high grade tumors were treated with doxurubicin, teniposide, cyclophosphamide and prednisolone (AVmCP).…”

Section: Chemotherapymentioning

confidence: 99%

“…Combined radical surgery and chemotherapy depending on the histologic grading were also associated with prolonged remission [73] . Resection of the tumor with clear margins is thought to have a better prognosis than with diseased margins [52,74,75] . However, other authors have found insignificant difference between the two procedures as long as post-operative chemotherapy was administered, and the extent of the disease at time of surgery, full thickness disease and lymph node involvement were important determining factors [39] .…”

Section: Combined Therapymentioning

confidence: 99%

“…On the other hand, surgery is advocated as the first option with adequate control of the disease [57][58][59]61] , and occasionally with the necessity of wide resection and extensive lymph node dissection [15,78] , however, adjuvant chemotherapy is indicated to control the local and distant disease if any [75,78] . In advanced stages of gastric lymphoma (stage IIIE, IVE) the behaviour of the tumor has the same manner as other advanced non-Hodgkin lymphomas, therefore combined chemotherapy is considered the treatment of choice for locally advanced or disseminated aggressive disease.…”

Section: Combined Therapymentioning

confidence: 99%

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Primary gastric lymphoma

Al-Akwaa¹,

Siddiqui²,

Al-Mofleh³

2004

WJG

102

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AIM:The purpose of this review is to describe the various aspects of primary gastric lymphoma and the treatment options currently available. METHODS:After a systematic search of Pubmed, Medscape and MDconsult, we reviewed and retrieved literature regarding gastric lymphoma. RESULTS:Primary gastric lymphoma is rare however, the incidence of this malignancy is increasing. Chronic gastritis secondary to Helicobacter pylori (H pylori) infection has been considered a major predisposing factor for MALT lymphoma. Immune histochemical marker studies and molecular biology utilizing polymerase chain reaction have facilitated appropriate diagnosis and abolished the need for diagnostic surgical resection. Advances in imaging techniques including Magnetic Resonance Imaging (MRI) and Endoscopic Ultrasonography (EUS) have helped evaluation of tumor extension and invasion. The clinical course and prognosis of this disease is dependent on histopathological sub-type and stage at the time of diagnosis. Controversy remains regarding the best treatment for early stages of this disease. Chemotherapy, surgery and combination have been studied and shared almost comparable results with survival rate of 70-90%. However, chemotherapy possesses the advantage of preserving gastric anatomy. Radiotherapy alone has been tried and showed good results. Stage IIIE, IVE disease treatment is solely by chemotherapy and surgical resection has been a remote consideration. CONCLUSION:We conclude that methods of diagnosis and staging of the primary gastric lymphoma have dramatically improved. The modalities of treatment are many and probably chemotherapy is superior because of high success rate, preservation of stomach and tolerable complications.Al-Akwaa AM, Siddiqui N, Al-Mofleh IA. Primary gastric lymphoma.

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Section: Chemotherapymentioning

confidence: 99%

Section: Combined Therapymentioning

confidence: 99%

Section: Combined Therapymentioning

confidence: 99%

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Primary gastric lymphoma

Al-Akwaa¹,

Siddiqui²,

Al-Mofleh³

2004

WJG

102

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“…Considerable relapse rates have been reported after apparently curative resection of GI lymphomas [39]. Although this situa tion may be improved by advances in preoperative staging, most centers perform adjuvant postoperative chemotherapy or less frequently radiotherapy or a combination of both.…”

Section: Therapy Of Gastrointestinal Lymphomas Stages I and Iimentioning

confidence: 99%

Primary Gastrointestinal Lymphoma

Schlag¹

1994

Oncol Res Treat

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Primary gastrointestinal lymphomas represent a specific entity which must be differentiated from nodal non-Hodgkin’s lymphomas due to its significantly different biological behavior, prognosis and treatment. In localized disease (stages IE and IIE) surgery can yield curative results. While adjuvant therapy is not necessarily required in stage-IEl tumors, postoperative chemotherapy or radiation are mandatory in the other stages or in residual disease. Multimodal therapy in stages IE and HE results in favorable prognosis as indicated by a 5-year survival rate of 75-90 %. In disseminated disease (stages IIIE and IVE) primary intensive combination chemotherapy (CHOP) is the therapy of first choice. Additional radiotherapy may be beneficial to eradicate localized tumors. Surgical resection of the tumor may eliminate hazardous sequelae of this therapy, e.g. hemorrhage, perforation. Inspite of intensive therapy, the prognosis of advanced gastrointestinal (GI) lymphoma remains poor, resulting in a 5-year survival rate of 10-30%.

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“…Non‐Hodgkin's lymphoma (NHL) with primary gastrointestinal localization (GI‐NHL) was first described by Billroth in 1871 [1]. GI‐NHL represents only 1–4% of the malignant tumours in the gastrointestinal tract [2–4]. The annual incidence rate in Scandinavia is about 1.5 cases per 100 000 adults [2].…”

Section: Introductionmentioning

confidence: 99%

Primary gastrointestinal non‐Hodgkin's lymphoma in adults: a population‐based clinical and histopathologic study

Hansen¹,

Vogt²,

Skov³

et al. 1998

Journal of Internal Medicine

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Abstract. Hansen PB, Vogt KC, Skov RL, PedersenBjergaard U, Jacobsen M, Ralfkiaer E (Herlev Hospital, University of Copenhagen and Gentofte Hospital, University of Copenhagen, Denmark). Primary gastrointestinal non-Hodgkin's lymphoma in adults: a population-based clinical and histopathologic study. J Intern Med 1998; 244: 71-8. Objectives.To analyse the clinical course and the histopathology of primary gastrointestinal nonHodgkin's lymphoma (GI-NHL) in adult patients and to investigate a possible impact of Helicobacter pylori. Design/setting. Retrospective study of all adult patients in Copenhagen county diagnosed during a 6-year period with NHL. Subjects. A total of 55 patients with GI-NHL diagnosed during the period from 1985 to the end of 1990. Results. Twenty-eight patients had primary lymphoma in the stomach, 14 in the small intestine, 11 in the large intestine and two patients had multifocal involvement. The dominant presenting symptoms were abdominal pain, weight loss, diarrhoea, constipation and fatigue. Acute emergency problems such as severe haemorrhage or perforation at initial presentation were unusual. According to the revised European-American lymphoma (REAL) classification, diffuse large B-cell lymphoma was the most frequent histologic subtype comprising 53% of the cases.Helicobacter pylori infection was documented in 15 of 25 evaluable patients (60%) with gastric lymphomas and was not associated with any specific histological subtype. Endoscopic procedures and barium X-rays were the diagnostic approaches with highest sensitivity. In total, 30 patients (58%) achieved complete remission, 10 (19%) achieved partial remission, and 12 (23%) did not respond to treatment. The overall 5 year survival rate was 0.36 without statistically significant difference between the histological subtypes. Likewise the presence of Helicobacter pylori did not affect survival. Conclusion. Primary GI-NHL is a heterogeneous disease entity with considerable therapeutic controversies. No specific clinical or histological phenotype was associated with the presence of Helicobacter pylori.

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Gastrointestinal lymphoma

Cited by 8 publications

References 115 publications

Primary gastric lymphoma

Primary gastric lymphoma

Primary Gastrointestinal Lymphoma

Primary gastrointestinal non‐Hodgkin's lymphoma in adults: a population‐based clinical and histopathologic study

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