Gastrointestinal Manifestations of Breast Cancer Metastasis

Zhang, Bing; Copur-Dahi, Nedret; Kalmaz, Denise; Boland, Brigid S.

doi:10.1007/s10620-014-3155-x

Cited by 13 publications

(9 citation statements)

References 9 publications

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“…In contrast, our case and another case from Zhang et al [ 4 ] illustrate that endoscopic findings might be almost normal. Another case described the presence of linitis plastica of the colon caused by metastatic breast carcinoma [ 5 ].…”

Section: Discussioncontrasting

confidence: 95%

Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

Bakker¹,

Moolenaar²,

Santen³

et al. 2016

Case Reports in Oncological Medicine

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A 70-year-old woman with a history of lobular breast cancer presented to our Outpatient Clinic with diarrhoea for the past 3 years. Clinical examination and laboratory research were normal. Colonoscopy showed diffuse mild erythema and a decreased vascular pattern. Biopsies from the ascending colon, transverse colon, and descending colon showed metastases of lobular breast carcinoma. Although gastrointestinal metastases are rare in breast cancer, our case emphasizes the need for further diagnostic efforts in patients with gastrointestinal symptoms and a history of breast carcinoma.

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Section: Discussioncontrasting

confidence: 95%

Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

Bakker¹,

Moolenaar²,

Santen³

et al. 2016

Case Reports in Oncological Medicine

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“…15 Endoscopic features of BC metastasis vary significantly and may include ulcers, mucosal thickening, mucosal friability, linitis plastica-like inflammation, polyps, strictures, or obstructing masses. 16 Given the broad spectrum of presentation, gastroenterologists performing endoscopic procedures in patients with a known history of BC, particularly of the lobular subtype, should remain vigilant for the possibility of metastatic disease and consider biopsy of any suspicious endoscopically visible lesion. Tissue sampling and immunohistochemistry are crucial to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Gastric and Colonic Metastasis of Breast Cancer

Botto,

Moiteiro Cruz,

Noronha Ferreira

et al. 2023

ACG Case Rep J

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Although breast cancer (BC) is the most common malignancy in women, metastasization to the gastrointestinal tract is rare. We present a 59-year-old woman with simultaneous gastric and colonic metastasis of invasive lobular breast carcinoma. She had been diagnosed with BC and underwent surgery and systemic therapy. Two years later, an increase in tumor markers motivated investigation, including upper and lower gastrointestinal endoscopy, which identified gastric ulcers and mucosal irregularity in the cecum. Histopathological analysis was compatible with gastric and colonic metastases from BC. We highlight the importance of biopsying every endoscopically visible lesion in patients with BC history.

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“…Endoscopic findings vary significantly and may range from ulcers, mucosal thickening or friability, linitisplastica-like inflammation, stenosis and polyps, to obstructing mass[ 24 ]. Barium studies reveal stricture or linitisplastica[ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Intestinal metastasis from breast cancer: Presentation, treatment and survival from a systematic literature review

Bolzacchini¹,

Nigro²,

Inversini³

et al. 2021

WJCO

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BACKGROUND Intestinal metastases from breast cancer (BC) arerare; available data depend mainly on case reports and case series. AIM To conduct a review of the literature regarding presentation, diagnosis, treatment and survival of patients with intestinal metastasis from BC. METHODS We identified all articles that described patients with intestinal metastasis (from duodenum to anum) from BC using MEDLINE (1975 to 2020) and EMBASE (1975 to 2020) electronic databases. RESULTS We found 96 cases of intestinal metastasis of BC. Metastasization involved large bowel (cecum, colon, sigmoid, rectum) (51%), small bowel (duodenum, jejunum, ileum) (49%), and anum (< 1%). Median age of patients was 61-years. The most frequent histology was infiltrating lobular carcinoma followed by infiltrating ductal carcinoma. In more than half of patients, the diagnosis was made after the diagnosis of BC (median: 7.2 years) and in many cases of emergency, for bowel obstruction, bleeding or perforation. Diagnosis was achieved through endoscopy, radiological examination or both. In most of the cases, patients underwent surgery with or without systemic therapies. Survival of patients included in this review was available in less than 50% of patients and showed an overall median of 12 mo since diagnosis of the intestinal metastasis. CONCLUSION Although, intestinal metastases of BC are considered a rare condition, clinicians should consider the possibility of intestinal involvement in case of abdominal symptoms even in acute setting and many years after the diagnosis of BC, especially in patients with a histology of lobular carcinoma.

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Gastrointestinal Manifestations of Breast Cancer Metastasis

Cited by 13 publications

References 9 publications

Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

Simultaneous Gastric and Colonic Metastasis of Breast Cancer

Intestinal metastasis from breast cancer: Presentation, treatment and survival from a systematic literature review

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