Gastrointestinal metastasis in hepatocellular carcinoma: Radiological and endoscopic studies of 11 cases

Lin, Chi‐Pin; Cheng, Jin‐Shiung; Lai, Kwok‐Hung; Lo, Gin‐Ho; Hsu, Pin‐I; Chan, Hoi‐Hung; Hsu, Jui-Hung; Wang, Yayu; Pan, Huay‐Ben; Tseng, Hui‐Hwa

doi:10.1046/j.1440-1746.2000.02152.x

Cited by 84 publications

(109 citation statements)

References 14 publications

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“…The biopsy specimen obtained from the esophageal lesion revealed that the tumor cells with pseudoglandular arrangement were covered with squamous cell epithelium ( nodes (26.5-41.7%), bone (4.2-16.3%), and adrenal glands (8.4-15.4%) (4-6). The incidence of premortem-diagnosed GI tract involvement is typically low in most studies, with some reporting rates of between 0.5 and 2% (3,7). In most reports, the involved site was the duodenum, stomach, colon, or jejunum, and the presumed mode of metastasis was usually direct invasion to the contiguous GI tract via adhesion to the serosal side of the tumor.…”

Section: Case Reportmentioning

confidence: 99%

Unusual Metastasis of Hepatocellular Carcinoma to the Esophagus

et al. 2005

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Section: Case Reportmentioning

confidence: 99%

Unusual Metastasis of Hepatocellular Carcinoma to the Esophagus

et al. 2005

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“…Although this occurrence was observed in approximately 10% of patients with HCC in a study of postmortem examinations, the incidence is reported to be 0.5% and 2% of clinical HCC cases (6,7). The organs involved included the duodenum, stomach, colon, or jejunum (8).…”

Section: Discussionmentioning

confidence: 97%

Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

Okay

Sari²,

Odabaşoğlu³

et al. 2014

Turk J Gastroenterol

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Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and is generally associated with hepatitis B or C virus-related cirrhosis. A giant intra-abdominal HCC mass that fills nearly the whole abdomen is not often reported in the literature. In this report, we present a case in which a patient with hepatitis B developed a giant intra-abdominal mass that originated from segment three of the liver and infiltrated the stomach and transverse colon. We were able to resect the tumor without leaving any tumor tissue behind. Although HCC presenting as a huge mass with invasion of the gastrointestinal tract is uncommon, this pathology should be considered in the differential diagnosis of giant intra-abdominal masses. The case presented here also indicates that surgical resection is possible in selected patients.

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“…HCC with direct invasion to other organs can occur, with the most frequent sites being the diaphragm and gallbladder [6] . HCC only rarely invades the GI tract, the reported incidence is 0.5%-2% of clinical HCC cases and 4% of autopsy cases [2,3,7] . GI bleeding or stenosis due to HCC invasion is very uncommon [8] .…”

Section: Discussionmentioning

confidence: 99%

“…GI bleeding or stenosis due to HCC invasion is very uncommon [8] . The most frequently invaded GI tract sites are the duodenum and stomach [2] and invasion into the colon is very rare. To date, only eight cases of invasion to the colon by HCC have been reported in the English literature (Table 1) [2,3,[9][10][11] .…”

Section: Discussionmentioning

confidence: 99%

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Direct invasion to the colon by hepatocellular carcinoma: Report of two cases

Hirashita¹,

Ohta²,

Iwaki³

et al. 2008

WJG

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Although hepatocellular carcinoma (HCC) is a common tumor, direct invasion of the gastrointestinal tract by HCC is uncommon. Recently, we encountered two cases of HCC with direct invasion to the colon. The first patient was a 79-year-old man who underwent transarterial chemo-embolization (TACE) for HCC 1.5 years prior to admission to our hospital. Computed tomography (CT) showed a 7.5-cm liver tumor directly invading the transverse colon. Partial resection of the liver and transverse colon was performed. The patient survived 6 mo after surgery, but died of recurrent HCC. The second patient was a 69-year-old man who underwent TACE and ablation for HCC 2 years and 7 months prior to being admitted to our hospital for melena and abdominal distension. CT revealed a 6-cm liver tumor with direct invasion to the colon. The patient underwent partial resection of the liver and right hemicolectomy. The patient recovered from the surgery. But, unfortunately, he died of liver failure due to liver cirrhosis one month later. Although the prognosis of HCC that has invaded the colon is generally poor due to the advanced stage of the disease, surgical resection may be a favorable treatment option in patients with a good general condition.

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Gastrointestinal metastasis in hepatocellular carcinoma: Radiological and endoscopic studies of 11 cases

Abstract: The prognosis in these patients was extremely poor. Almost all patients died within 5 months if no further aggressive management was performed. Surgical intervention may be the optimal choice for palliative treatment of HCC with gastrointestinal tract involvement.

Cited by 84 publications

References 14 publications

Unusual Metastasis of Hepatocellular Carcinoma to the Esophagus

Unusual Metastasis of Hepatocellular Carcinoma to the Esophagus

Hepatocellular carcinoma presenting as a huge intra-abdominal mass: A case report

Direct invasion to the colon by hepatocellular carcinoma: Report of two cases

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