Gastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography – a pilot study

Abstract

Studies of gastrointestinal function during sleep are hampered by lack of applicable techniques. Recent development of a novel ambulatory telemetric capsule system, which can be used in conjunction with polysomnography, offers a solution to this problem. The 3D-Transit system consists of ingestible electromagnetic capsules traceable through a portable extracorporeal receiver while traversing the gut. During sleep monitored by polysomnography, gastrointestinal motility was concurrently investigated using 3D-Transit in nine healthy subjects. Overall, the amplitude of gastric contractions decreased with depth of sleep (light sleep, N2 versus deep sleep, N3; P<0.05). Progression through the small intestine did not change with depth of sleep (Kruskal–Wallis probability =0.1), and there was no association between nocturnal awakenings or arousals and the occurrence of colonic or small intestinal propagating movements. Basal colonic activity was suppressed during both deep sleep (P<0.05) and light sleep (P<0.05) when compared with nocturnal wake periods. In conclusion, the novel ambulatory 3D-Transit system combined with polysomnography allows minimally invasive and completely ambulatory investigation of associations between sleep patterns and gastrointestinal motility.

Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system: Effect of opioids

“…The present study focuses solely on colonic recordings. Ileocecal passage was determined by the capsule's two‐dimensional location in the lower right abdomen and a decrease in contraction frequency from six to three contractions per minute . Prior to classification of movement patterns, all fast capsule movements (>4 cm with a mean velocity >4 cm/min) were identified using an automated algorithm (Motilis Medica SA) .…”

Assessment of colorectal length using the electromagnetic capsule tracking system: a comparative validation study in healthy subjects

“…Colorectal lengths were estimated using the 3D-Transit position data from the electromagnetic pill recordings. Ileocaecal passage of the capsule was located using the same method as described in previous publications [10][11][12][13][14]. Data recorded from ileocaecal passage to expulsion were regarded as recordings from the colorectum.…”

In-vitro–in-silico investigation of the negative food effect of zolpidem when administered as immediate-release tablets

“…It is known that there is a profound inhibitory effect on gastrointestinal (GI) motility pattern during sleep. Several studies have demonstrated the suppression of both gastric and colonic motilities . On the other hand, the delay in gastric emptying due to the supine position is controversial.…”

“…Several studies have demonstrated the suppression of both gastric and colonic motilities. [46][47][48][49] On the other hand, the delay in gastric emptying due to the supine position is controversial. Some studies have shown no significant effect of body position in the gastric emptying time, [50][51][52] whereas others have shown differences in GET due to changes in body position.…”