Gastrointestinal Stromal Tumor Mimicking Gynecological Disease

Morimura, Yutaka; Yamashita, Naoyuki; Koyama, Nobuatsu; Ohzeki, Takeharu; Takayama, Tomoko; Fujimori, Keiya; Sato, Akira

doi:10.5387/fms.52.21

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…Our patient had a tumor greater than 30 cm and a mitotic count of more than 5/50 HPF, so we expected a poor prognosis. This case is particularly unusual because of the extremely large tumor size (30 × 20 × 15 cm); others authors have reported mean GIST sizes of 6-10.6 cm [4][5][6][7][8]. In addition, the tumor had a very high mitotic count of up to 8-9/50 HPF and, as mentioned previously, arose from the sigmoid colon.…”

supporting

confidence: 53%

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Gastrointestinal Stromal Tumor (GIST) Presenting as a Huge Pelvic Mass

Lee

2013

Geburtsh Frauenheilk

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supporting

confidence: 53%

“…Around 15-50 % of patients with GISTs have metastatic disease [6]. Because of their histology, GISTs presenting as pelvic masses can be mistaken for gynecological disease, such as ovarian tumor or uterine leiomyoma [7]. The majority of GISTs have diameters of less than 10 cm.…”

mentioning

confidence: 99%

Gastrointestinal Stromal Tumor (GIST) Presenting as a Huge Pelvic Mass

Lee

2013

Geburtsh Frauenheilk

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“…A review of the literature has shown that a diagnostic dilemma prevails in cases similar to this. There are reported incidences where suspected gynecological neoplasms turned out to be GISTs [3][4][5][6]. Morimura et al [3] reported two cases of GISTs mimicking gynecologic neoplasms (preoperative diagnoses of ovarian fibrothecoma and subserosal leiomyoma).…”

Section: Discussionmentioning

confidence: 99%

“…There are reported incidences where suspected gynecological neoplasms turned out to be GISTs [3][4][5][6]. Morimura et al [3] reported two cases of GISTs mimicking gynecologic neoplasms (preoperative diagnoses of ovarian fibrothecoma and subserosal leiomyoma). Similarly, Lee [4] reported a proven case of GIST that was initially diagnosed as ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Giant Fibroid Mimicking a Gastrointestinal Stromal Tumor: A Diagnostic Dilemma

Priyadharshinee¹,

Sahu²,

Chavadi³

2023

Cureus

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Uterine fibroids are the most common benign pelvic tumors in females of the reproductive age group. Usually, fibroids are confined to the uterus. Here, we report an interesting and rare case of a large 17 cm abdominopelvic mass lesion that led to a diagnostic dilemma between a mesenteric gastrointestinal stromal tumor (GIST) and a uterine fibroid. We had a 26-year-old female who underwent an ultrasound examination of the abdomen as the initial imaging modality and was found to have an abnormally large solid abdominopelvic mass lesion. For further evaluation, a contrast-enhanced CT examination of the abdomenpelvis was done. Initially, on first look, the mass was thought to be of mesenteric origin, but on further review of images, it was found to be of gynecological origin. Intraoperatively, the solid mass was seen attached to the uterine fundus and underwent excision. Histopathological examination confirmed the mass to be a uterine fibroid. This case study describes the uncommon appearance of this tumor in a young woman, including the clinical presentation, imaging, and surgical findings.

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“…Conversely, PDGFR-α mutations can explain response and sensitivity to imatinib in some GISTs lacking KIT mutations [6]. The best prognostic features are tumor size and mitotic activity; however, it does not predict the risk for disease progression and malignant potential accurately because of the scarcity of primary omental GIST [7][8][9][10]. There are a few reported cases of GISTs that involved gynecologic tract and presented as pelvic or omental masses, therefore mimicking primary omental or ovarian neoplasm [8,9,[11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Gastrointestinal Stromal Tumor to the Omentum and Endometrium: A Case Report

2022

IJOR

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Gastrointestinal Stromal Tumor (GIST) is an uncommon stromal malignancy of Gastrointestinal (GI) tract. GISTs have been increasingly reported in sites other than GI tract. Currently, GISTs are considered metastatic when they occur outside GI tract; however, there is a possibility of a primary stromal tumor of omentum and/or gynecologic tract with similar mutation profile and histopathology but different prognosis and clinical behavior. Here, we report a case of 52-year-old female with widespread lesions in her abdomen and pelvis, which turned out to be a GIST; however, no lesions were identified in the GI tract which raises the possibility of omental or ovarian primary stromal tumor. Since GISTs are mutation derived tumors, it is highly likely that the stroma of other locations can undergo similar tumorigenesis due to mutations in c-KIT and/or PDGFRA genes and present similarly to primary GI tract GISTs. More studies are required to look for other possible primary sites and difference in clinical behavior and prognosis to appropriately stage the patient before treatment, as GISTs that occur outside GI tract tends to behave aggressively and are usually resistant to imatinib therapy. Keywords: Gastrointestinal stromal tumor; Omentum; Endometrium; Metastasis; Epithelioid; Carcinomatosis

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Gastrointestinal Stromal Tumor Mimicking Gynecological Disease

Cited by 12 publications

References 6 publications

Gastrointestinal Stromal Tumor (GIST) Presenting as a Huge Pelvic Mass

Gastrointestinal Stromal Tumor (GIST) Presenting as a Huge Pelvic Mass

Giant Fibroid Mimicking a Gastrointestinal Stromal Tumor: A Diagnostic Dilemma

Metastatic Gastrointestinal Stromal Tumor to the Omentum and Endometrium: A Case Report

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