Gastrointestinal stromal tumors: Differential diagnosis

Dow, Nancy; Giblen, Georgeta; Sobin, Leslie H.; Miettinen, Markku

doi:10.1053/j.semdp.2006.09.002

Cited by 75 publications

(38 citation statements)

References 52 publications

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“…Further, the diagnosis is confirmed by demonstration of PDGFRA immunoreactivity and a PDGFRA gene mutation. Differential diagnosis includes KIT-positive non-GIST tumors such as small round cell tumors, granulocytic sarcoma, clear cell sarcoma, mast cell neoplasms, seminoma, and small cell carcinoma [2,3,19]. The present study is different from these tumors in the histology, immunohistochemistry, and mutations of the PDGFRA gene.…”

Section: Discussionmentioning

confidence: 70%

Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations

Terada

2008

Med Oncol

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The author reports a rare case of primary large cystic extragastrointestinal stromal tumor (eGIST) of the transverse mesocolon with genetic analyses of the c-kit and platelet-derived growth factor receptor-alpha (PDGFRA) genes. A 78-year-old man was found to have a large cystic tumor in the abdomen, and the tumor was resected. Grossly, the tumor was located in the transverse mesocolon, and cystic. Microscopically, the tumor consisted of epithelioid cells with atypia. Mitotic figures were noted in five of 50 high power fields. Immunohistochemically, the tumor cells were positive for KIT, CD34, PDGFRA, and vimentin, but negative for cytokeratins, neuron specific enolase, desmin, S100 protein, alpha-smooth muscle actin, p53 protein, HMB45, CD68, CEA, factor VIII-related antigen, chromogranin, and synaptophysin. Ki67 labeling was 5%. Genetically, the tumor showed a point mutation (GAC --> GTC) at codon 842 of exon 18 of the PDGFRA gene. Exon 12 of the PDGFRA gene and exons 9, 11, 13, and 17 of the c-kit gene showed no mutations. No recurrence is noted 3 years after the operation. This case shows that eGIST may occur in the transverse mesocolon.

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Section: Discussionmentioning

confidence: 70%

Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations

Terada

2008

Med Oncol

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“…According to foreign reports, the incidence of GISTs is 1-2/100, 000, under 3% of total gastrointestinal tumors, however, GISTs is the most common mesenchymal tumors of the digestive tract. It can appeared anywhere of the digestive tract, most commonly in stomach (60%-70%), small intestine (20%-30%), or rectum and colon(5%), esophagus fewer than 5%, and sometimes in omentum and mesenterium (Miettinen et al, 2005;Dow et al, 2006;Stamatakos et al, 2009). The age peak of incidence is 55-65, male slightly higher than female or almost equal for both sexes (Bórquez Ma et al, 2008;Corless et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology

Sun

Feng²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…GIST may show cyst formation, hemorrhage, necrosis, occasionally seen in some IMTs. GIST typically does not have the inflammatory background as seen in the IMT [13]. In addition, some GIST cells have cytoplasmic vacuoles, a feature not seen in the IMT.…”

Section: Discussionmentioning

confidence: 96%

Primary Gastric Inflammatory Myofibroblastic Tumor in an Adult—Case Report With Brief Review

Katakwar

Gedam

Mukewar

et al. 2014

Indian J Surg Oncol

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The term inflammatory myofibroblastic tumor more commonly referred to as "pseudostumor ", denotes a pseudosarcomatous inflammatory lesion that contains spindle cells, myofibroblasts, plasma cells, lymphocytes and histiocytes. It exhibits a variable biological behavior that ranges from frequently benign lesions to more aggressive variants. Inflammatory myofibroblastic tumor (IMT) of the stomach is extremely rare and its prognosis is unpredictable. We present a 45-year-old diabetic man with a gastric Inflammatory myofibroblastic tumor. The histopathological and immunohistochemical analysis was the key to reach diagnosis.

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Gastrointestinal stromal tumors: Differential diagnosis

Cited by 75 publications

References 52 publications

Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations

Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations

Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology

Primary Gastric Inflammatory Myofibroblastic Tumor in an Adult—Case Report With Brief Review

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