Gastrointestinal stromal tumors (GISTs) of the colon

Macias-García, Fernando; Parada, P; Martínez-Lesquereux, L; Pintos, Elena; Fraga, Máximo; Domínguez–Muñoz, J. Enrique

doi:10.4321/s1130-01082010000600010

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…But in all our cases is advance size the smaller diameter is 8 cm, obstruction and abdominal pain is the most common complication. Tung-Cheng write that the most common symptoms of rectal GIST are tenesmus and lower GI bleeding, which are similar to those of other kinds of rectal tumors [1] [8].…”

Section: Discussionmentioning

confidence: 99%

“…Surgery is the standard treatment for localized primary disease without metastatic involvement, with a 5-year survival range from 45% to 65%. Endoscopic resection could be an option if technically feasible by tumor size or location but in our second case the rectal polyp size is the huge ( φ 8 cm) so we performed low anterior resection [1]- [3].…”

Section: Discussionmentioning

confidence: 99%

“…However, the term GIST is only applied to gastrointestinal mesenchymal neoplasms witch are c-kit positive, with rare exceptions. Approximately 95% of GISTs are positive for expression of the KIT (CD117, stem cell factor receptor) protein and as well as 70% -80% of GISTs expressing CD34, the human progenitor cell antigen [1]- [3]. Risk of malignancy is based on the primary tumor diameter and the mitotic count.…”

Section: Discussionmentioning

confidence: 99%

“…GISTs bear good prognosis after margin negative surgery. Tumor size and mitotic activity are best predictive prognostic features; small intestinal tumors behave more aggressively than gastric tumors with similar parameters [1] [2] [6].…”

Section: Introductionmentioning

confidence: 99%

“…Seventy percent to 80% of GISTs are benign, and such tumors are often found incidentally at surgery and excised in the same session. Approximately 20% to 30% of GISTs are malignant, and these neoplasms are identified based on their mitotic index, tumor necrosis index, and Ki-67 index (which reflects expression of the 395 kDa nuclear antigen MIB-1) [1]- [5].…”

Section: Introductionmentioning

confidence: 99%

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Management Colorectal Gastrointestinal Stromal Tumors (Gists) in Surabaya

Handaya¹,

Wibowo²,

Kristian³

2016

OJGas

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Management Colorectal Gastrointestinal Stromal Tumors (Gists) in Surabaya

Handaya¹,

Wibowo²,

Kristian³

2016

OJGas

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Clinicopathologic factors predicting outcomes in patients with gastrointestinal stromal tumors of the rectum and colon

Zhou¹,

Chen²,

Chen³

et al. 2013

Tumor Biol.

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Limited information is available concerning the clinicopathologic profile of colorectal gastrointestinal stromal tumors (GISTs), which are relatively rare, as well as survival rates following surgical resection. The present study was designed to describe the clinicopathologic characteristics of patients with colorectal GISTs and identify potential factors that may predict postoperative survival outcomes. We reviewed the medical records of 67 patients with colorectal GISTs who underwent surgical resection between January 2000 and December 2012. Clinicopathologic factors affecting overall survival were assessed using the Kaplan-Meier method and multivariate Cox proportional hazards models. The median age at diagnosis was 57 years (range, 32-79 years), with a male-to-female ratio of 1.68. Tumor size varied from 0.2 to 11 cm, with a median size of 5.7 cm. Sixty-two tumors (93%) were positive for CD117, 53 (79%) for CD34, 6 (9%) for PDGFRA, 15 (22%) for SMA, 5 (8%) for S100, and 39 (58%) for vimentin. The overall median survival time was 54 months (95% confidence interval, 32-59 months), and the 1-, 3-, and 5-year overall survival rates were 89.6, 63.9, and 34.4%, respectively. High-risk tumors (determined by histologic grade, size, and other histologic variables) were associated with poor prognosis (hazard ratio, 1.83; 95% confidence interval, 1.21-2.78), and patients who received adjuvant treatment with imatinib had significantly longer median overall survival times than patients who did not (hazard ratio, 0.43; 95% confidence interval, 0.24-0.80). In patients with colorectal GISTs, high-risk tumor histologic grade can predict poor prognosis, and patients may benefit from adjuvant treatment with imatinib. Findings from the present study may provide information to establish evidence-based management strategies for colorectal GISTs.

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Clinicopathological features and prognosis of colonic gastrointestinal stromal tumors: evaluation of a pooled case series

et al. 2016

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BackgroundDue to the extremely rare incidence, data about colonic GISTs are limited. Therefore, aim of the present study was to explore clinicopathological characteristics and prognosis of colonic GISTs.Patients and MethodsColonic GISTs cases were obtained from our center and from case report and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analyzed.ResultsThere were 79 colonic GISTs patients with a female predominance. The median age was 66 years (range 0.17-84). The median tumor size was 5.8 cm (range 0.5-29). The most common location was sigmoid colon (45.8%), followed by transverse colon (19.5%). The majority of colonic GISTs were high risk (70.8%). Mitotic index was correlated with gender (P = 0.002) and tumor size (P = 0.005), and tumor location was correlated with age (P = 0.017). The five year DFS and DSS were 57.4% and 61.6%, respectively. Mitotic index and NIH risk classification were associated with prognosis of colonic GISTs. However, mitotic index was the only independent risk factor. The distribution of tumor size and NIH risk classification were significantly different between colonic and gastric GISTs (both P = 0.000). The DFS and DSS of colonic GISTs were significantly lower than that of gastric GISTs (P = 0.012 and P = 0.002, respectively).ConclusionsThe most common location for colonic GISTs was sigmoid colon. Most tumors were high risk. Mitotic index was the only independent risk factor for prognosis of colonic GISTs. Colonic GISTs differ significantly from gastric GISTs in respect to clinicopathological features. The prognosis of colonic GISTs was worse than that of gastric GISTs.

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Gastrointestinal stromal tumors (GISTs) of the colon

Cited by 5 publications

References 13 publications

Management Colorectal Gastrointestinal Stromal Tumors (Gists) in Surabaya

Management Colorectal Gastrointestinal Stromal Tumors (Gists) in Surabaya

Clinicopathologic factors predicting outcomes in patients with gastrointestinal stromal tumors of the rectum and colon

Clinicopathological features and prognosis of colonic gastrointestinal stromal tumors: evaluation of a pooled case series

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