Gastrointestinal Tract Metastases of Invasive Lobular Carcinoma of the Breast: An Immunohistochemical Survey Algorithm

Zengel, Baha; Cavdar, Demet Kocatepe; Özdemir, Özlem; Taşlı, Funda; Karataş, Murat; Şimşek, Cenk; Uslu, Adam

doi:10.4274/ejbh.galenos.2022.2022-1-5

Cited by 6 publications

(10 citation statements)

References 33 publications

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“…The diagnosis of BC was based on part of the biopsy tissue, not the surgical specimen. It is possible that the tumor originally had an ILC component based on the fact that ILC is able to metastasize to the gastrointestinal tract [ 9 ]. Interestingly, Mori et al reported a similar case in which BC was diagnosed as IDC and the appendix was diagnosed as ILC [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review

Yagyu,

Miki,

Kikawa

et al. 2024

Cureus

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Appendiceal metastases of breast cancer (BC) are very rare, and there are few reports of resection. Asymptomatic appendiceal enlargement is often suspected to be a primary appendiceal tumor, making it difficult to suspect metastatic tumors, especially metastases from BC. On the other hand, advances in drug therapy, including hormonal therapy for BC, have prolonged survival, and there is a possibility of encountering metastatic cases that have rarely been seen before. We herein present a case in which an enlarged appendix, identified during hormonal therapy for advanced BC, was laparoscopically removed and diagnosed as BC metastasis. A 53-year-old woman had been diagnosed with invasive ductal carcinoma (IDC) based on a breast biopsy, and the appendiceal specimen was diagnosed as invasive lobular carcinoma (ILC). We herein report this unique case and provide a detailed review of 13 previous reports.

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Section: Discussionmentioning

confidence: 99%

Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review

Yagyu,

Miki,

Kikawa

et al. 2024

Cureus

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“…[18] It is extremely rare for a patient with breast cancer to have both gastric and colonic metastases at the same time. Up to now, only ve case reports can be retrieved on PubMed and Web of Science [12,[19][20][21][22] , so we cannot obtain the speci c incidence rate.…”

Section: Discussionmentioning

confidence: 99%

“…Both Inoue and Zengel's case reports indicated positive expression of ER, GATA-3, CK7 and negative expression of CK20 in colonic metastases. [9,12] Horimoto presented a case of colonic polyp metastasis from breast cancer that was GCDFP-15 positive, CK7 positive and CK20…”

Section: Discussionmentioning

confidence: 99%

“…However, it is still di cult for clinicians to identify the origin for patients with gastric or colonic carcinoma who have histories of breast cancer. [12,15] We found a rare case that one patient diagnosed invasive lobular carcinoma developed abdominal discomfort 20 months after radical operation. Through our assessment, it was eventually diagnosed as gastric, liver and bone metastases from breast cancer.…”

Section: Introductionmentioning

confidence: 96%

“…[2][3][4][5][6][7][8] Similarly, researches on breast cancer with colonic metastasis also stay at case reports. [9][10][11][12] It is extremely rare to have both gastric and sigmoid colonic metastases in one case.…”

Section: Introductionmentioning

confidence: 99%

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Gastric and Sigmoid Colonic Metastases from Breast Cancer: A Case Report and Literature Review

Huang

Chen

Jin

et al. 2023

Preprint

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Background Breast cancer has become the most commonly diagnosed cancer in the world, but gastrointestinal metastasis from breast cancer is rare. It is extremely rare to have both gastric and sigmoid colonic metastases in one case. For patients considered gastric or colon carcinoma who have a history of breast cancer, it is difficult to identify the origin. Even so, clinicians still need to make accurate diagnosis due to great different treatment principles. Case presentation: We present a case that diagnosed as metachronous gastric and sigmoid colonic metastases from invasive lobular carcinoma of the breast. On June 7, 2021, A 65-year-old female patient came to our department complained recurrent abdominal discomfort for one week. Gastroscopy in our hospital suggested that there was a superficial depressed lesion (type IIC) in her gastric antrum, while pathology indicated poorly differentiated carcinoma. Combined with the patient's breast cancer history and immunohistochemical results, we accurately diagnosed her as gastric metastasis of breast cancer rather than primary gastric cancer. During systematic treatment progress, sigmoid colonic metastasis was detected with colonoscopy on September 19, 2022. Up to May 2023, the patient is still alive with an overall survival greater than 23 months. Conclusions Gastrointestinal metastasis of breast cancer is rare in clinical work, but the incidence of autopsy is up to 15–16%. This phenomenon suggests that some patients with advanced breast cancer have not been accurately diagnosed, which may lead them to receive inappropriate treatment. At present, estrogen/progesterone receptor (ER/PR), GATA binding protein-3 (GATA-3), cytokeratin 7/20 (CK7/20), gross cystic disease fluid protein-15 (GCDFP-15) and mammaglobin are the most diagnostic immunohistochemical markers.

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Invasive lobular carcinoma of the breast with colonic metastasis: a case series of three patients

Otsuka,

Komuro,

Suzuoki

et al. 2023

surg case rep

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Background Although metastatic spread of breast cancer to the gastrointestinal tract is very rare, it is more likely to occur in invasive lobular carcinoma (ILC) than in ductal carcinoma. Colonic metastasis is particularly rare, and the treatment strategies for these cases are not clearly defined. Herein, we report three cases of ILC with various abdominal symptoms associated with colonic metastasis. Case presentation Case 1 A 70-year-old female patient with vomiting and melena was referred to our hospital. Endoscopic examination revealed a Dieulafoy ulcer in the rectum and an elevated lesion in the descending colon. She also had two breast nodules, and was diagnosed as ILC with colonic metastasis. Considering her general condition, the best supportive care (BSC) was offered. The patient died 4 months after confirmation of the diagnosis. Case 2 An 80-year-old female patient presented with diarrhea and vomiting. She was diagnosed with ILC with colonic metastasis, and a coloscopy revealed stenosis of the transverse colon with a metastatic lesion. Ileosigmoid bypass surgery was performed for intestinal obstruction, and systemic treatment for breast cancer was initiated. The patient developed peritoneal carcinomatosis and died 1 year and 2 months after surgery. Case 3 A 56-year-old female patient underwent left total mastectomy for ILC, and laparoscopic transverse colectomy was conducted for a colonic lesion 9 years and 2 months after. The diagnosis as colonic metastasis was not confirmed at that time. Two years and 2 months later, torose lesions were detected in the hepatic flexural and descending colon, and histopathological findings indicated that all colon tumors, including the previously resected tumor, were metastatic spread of ILC. Systemic treatment was continued, but the transverse colonic lesion penetrated the abdominal wall, and an abscess formed 2 years and 11 months after the resection. The fistula improved by continuous suction drainage following ileostomy but recurred, and the patient died 3 years and 8 months after colectomy. Conclusions Colonic metastases from breast cancer can trigger various abdominal symptoms, and the prognosis in these cases is generally poor. In selected cases, surgical treatment for abdominal symptoms and subsequent systemic therapy can contribute to a prolonged prognosis.

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Gastrointestinal Tract Metastases of Invasive Lobular Carcinoma of the Breast: An Immunohistochemical Survey Algorithm

Cited by 6 publications

References 33 publications

Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review

Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review

Gastric and Sigmoid Colonic Metastases from Breast Cancer: A Case Report and Literature Review

Invasive lobular carcinoma of the breast with colonic metastasis: a case series of three patients

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