Objective. To evaluate the efficiency and safety of sentinel lymph node biopsy (SLNB) in patients with breast cancer with complete response to neoadjuvant chemotherapy (NAC). Methods. Ninety-two consecutive (T1-4 and N1-2) patients with breast cancer who had pathologic and/or clinical and radiologic axillary lymph node involvement were included. All patients received NAC. Patients with a clinical and radiologic complete response in the axilla after NAC underwent SLNB. Pathologic complete response (ypCR) was defined as the absence of residual invasive and in situ cancer, and near-complete response (ypNCR) represented in situ and/or ≤ 1 mm residual tumor in the breast and/or presence of malignant cell clusters (≤0.2 mm) and/or micrometastases (≤2.0 mm) in the axillary lymph nodes (ALN) (ypTis/T1mi, ypN0i+/pN1mi). Results. The mean age of the 92 patients was 49.6 ± 10.3 years and the mean follow-up was 34.0 ± 17.8 months. With respect to breast tumors, 23 (25.0%) patients had complete and 14 (15.2%) had a near-complete response to NAC. Complete response in ALN was obtained in 39 (42.4%) patients and near-complete in six (6.5%) patients. The overall survival of the 33 patients who achieved ypCR and ypNCR was 100% and the remaining 59 patients with partial or no response to NAC was 83.1% at a mean follow-up of 34 months ( p = 0.063 ). Conclusions. In this study, no event developed in cases with ypCR and ypNCR in the breast and axilla. The persistence of the same results in long-termfollow-ups may enable the use of ypNCR as a positive prognostic marker in addition to ypCR.

The histopathological findings are similar in invasive lobular carcinoma of the breast and poorly cohesive carcinoma of the stomach. Therefore, the possibility of metastasis should be kept in mind in multiple erosions or linitis plastica type gastric lesions. •In breast cancer patients who develop gastrointestinal tract metastases, determining the nature of the tumor (primary or metastatic) is extremely important in terms of treatment. •The importance of histopathological examination is critical and is highlighted in this report.• Possible diagnostic errors can be avoided by making immunophenotypic evaluation of endoscopic biopsy material with an appropriate immunohistochemical panel.

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Aim: It was aimed to compare the breast cancer patients who were progressed or unresponsive to neoadjuvant chemotherapy with the patients clinically responsive to the treatment at interim radiological assessment. Materials and Methods: Female patients operated in our hospital for breast cancer after neoadjuvant chemotherapy were retrospectively screened. Patients having interim radiological assessment were included in the study. Patients were divided into three groups as responsive, unresponsive (stable) and progressive according to the imaging results. Unresponsive and progressive patients were compared to responsive patients in terms of patient and tumor characteristics. Results: A total of 96 patients were included in the study. According to the interim imaging results, 90.6% of patients (87 patients) had a radiological response to the treatment. Four patients (4.2%) with radiological unresponsiveness and five patients (5.2%) with radiological progression (9 patients in total, 9.4%) were referred to operation. The mean age of the unresponsive patients was found to be statistically higher than the responding patients (60 vs. 49, p=0.035). The tumor grade and Ki-67 index of unresponsive patients were lower than the responsive patients (respectively; 1.5±0.6 vs. 2.4±0.5, p=0.007 and 10±4 vs. 37±22, p=0.003). Although the tumor grade and Ki-67 index were higher in patients who progressed than the responders, they weren’t statistically significant. Unresponsive patients were mostly luminal A (3/4 patients), and progressive patients were mostly triple negative (3/5 patients) molecular subtype. Conclusion: Luminal breast cancers with low proliferation index and grade tend to be insensitive to neoadjuvant chemotherapy. On the other hand, hormone receptor negative tumors with high proliferation index and grade may respond well to neoadjuvant chemotherapy and may also pose a risk for progression. Further clinical studies are needed.