Gastrointestinal Tract, Microbiota and Multiple Sclerosis (MS) and the Link Between Gut Microbiota and CNS

Yousefi, Bahman; Babaeizad, Ali; Banihashemian, Seyedeh Zahra; Feyzabadi, Zahra Khatibiyan; Dadashpour, Mehdi; Pahlevan, Daryoush; Ghaffari, Hadi; Eslami, Majid

doi:10.1007/s00284-022-03150-7

Cited by 7 publications

(4 citation statements)

References 101 publications

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“…The study by Yousefi et al (2022) reviews current literature on the relationship between the gastrointestinal tract, microbiota, and MS, as well as the connection between the gut microbiota and the central nervous system. The authors point out that intestinal dysbiosis and chronic inflammation are common in patients with MS, and that this dysfunction can affect the permeability of the blood-brain barrier, allowing the entry of inflammatory molecules and causing damage to the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of the disease varies in different countries, with higher rates in temperate areas. It is estimated that MS affects about 35 out of every 100,000 people in Europe and 18 out of every 100,000 people in the United States (Yousefi et al, 2022). Furthermore, MS is more common in individuals of Caucasian descent than in other ethnicities, although the disease is becoming increasingly common in other ethnic groups (Moles et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Multiple Sclerosis and Intestinal Dysbiosis: An Integrative Review

Santos,

Moura,

Oliveira

et al. 2023

JHS

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The aim of the present study is to provide a better understanding of the relationship between MS and intestinal dysbiosis, which may lead to new strategies for the prevention and treatment of the disease. Methodology: Integrative review on the relationship between MS and intestinal dysbiosis, PubMed and Scopus databases were used, considering articles published in the last 5 years. Nine studies were included to compose the collection. Results: The results of recent studies suggest that intestinal dysbiosis may be associated with the development of MS, since the intestinal microbiota plays an important role in modulating the immune system. They discuss possible mechanisms by which intestinal dysbiosis can lead to MS, including activation of immune cells and production of pro-inflammatory cytokines. Conclusion: It can be suggested that treatment with probiotics, prebiotics and other interventions aimed at modulating the intestinal microbiota may represent a promising approach in the treatment of multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Multiple Sclerosis and Intestinal Dysbiosis: An Integrative Review

Santos,

Moura,

Oliveira

et al. 2023

JHS

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show abstract

“…Polysaccharides are poorly absorbed directly by the gut, and they require assistance from gut microbes for digestion, which confirms interactions between polysaccharides and gut microbes [ 132 ]. In fact, they can serve as a carbon source and be fermented by gut microbes to produce SCFAs [ 133 ]. Natural plant polysaccharides are potent in alleviating symptoms in mice with enteritis by modulating inflammatory factors and intestinal barrier proteins.…”

Section: Pharmacological Interventions For Ibd and Their Effects On G...mentioning

confidence: 99%

Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

Zhu

Song

et al. 2023

IJMS

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Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn’s disease (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD and offers promising strategies for IBD remedies. A brief overview of the variations occurring in intestinal flora during IBD is presented, and the role of the gut microbiota in intestinal barrier maintenance, immune and metabolic regulation, and the absorption and supply of nutrients is reviewed. More importantly, we review drug research on gut microbiota in the past ten years, including research on clinical and natural drugs, as well as adjuvant therapies, such as Fecal Microbiota Transplantation and probiotic supplements. We also summarize the interventions and mechanisms of these drugs on gut microbiota.

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“…Elucidating these mechanisms of action will provide an experimental basis for the development of novel, safe, and effective treatments for MS. Studies have confirmed that altered activity of the HPA axis was implicated in the pathogenesis and progression of MS [ 11 ]. Changes in the intestinal flora can stimulate both the enteric nervous system and activation of the HPA axis [ 12 , 13 ]. Consequently, we speculate that FMT can ameliorate MS symptoms by rebuilding intestinal homeostasis, regulating immunity and neuroendocrine through HPA axis.…”

mentioning

confidence: 99%

Therapeutic effects and mechanisms of fecal microbiota transplantation on EAE partly through HPA axis-mediated neuroendocrine regulation

Xu,

Ren,

Zhang

et al. 2024

Heliyon

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Gastrointestinal Tract, Microbiota and Multiple Sclerosis (MS) and the Link Between Gut Microbiota and CNS

Cited by 7 publications

References 101 publications

Relationship Between Multiple Sclerosis and Intestinal Dysbiosis: An Integrative Review

Relationship Between Multiple Sclerosis and Intestinal Dysbiosis: An Integrative Review

Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

Therapeutic effects and mechanisms of fecal microbiota transplantation on EAE partly through HPA axis-mediated neuroendocrine regulation

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