Gastroprotection of (‐)‐α‐bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms

Abstract

(-)-Alpha-Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla. (-)-Alpha-Bisabolol has generated considerable economic interest, since it possesses a delicate floral odor and has been shown to have anti-septic and anti-inflammatory activity. The aim of this work was to evaluate the gastroprotective action of (-)-alpha-bisabolol on ethanol and indomethacin-induced ulcer models in mice, and further investigate the pharmacological mechanisms involved in this action. The oral administration of (-)-alpha-bisabolol 100 and 200 mg/kg was able to protect the gastric mucosa from ethanol (0.2 mL/animal p.o.) and indomethacin-induced ulcer (20 mg/kg p.o.). Administration of L-NAME (10 mg/kg i.p.), glibenclamide (10 mg/kg i.p.) or indomethacin (10 mg/kg p.o.) was not able to revert the gastroprotection promoted by (-)-alpha-bisabolol 200 mg/kg on the ethanol-induced ulcer. Dosage of gastric reduced glutathione (GSH) levels showed that ethanol and indomethacin reduced the content of non-protein sulfhydryl (NP-SH) groups, while (-)-alpha-bisabolol significantly decreased the reduction of these levels on ulcer-induced mice, but not in mice without ulcer. In conclusion, gastroprotective effect on ethanol and indomethacin-induced ulcer promoted by (-)-alpha-bisabolol may be associated with an increase of gastric sulfydryl groups bioavailability leading to a reduction of gastric oxidative injury induced by ethanol and indomethacin.

Special Licorice Extracts Containing Lowered Glycyrrhizin and Enhanced Licochalcone A Prevented Helicobacter pylori‐Initiated, Salt Diet‐Promoted Gastric Tumorigenesis

“…The mean pathologic index was calculated following the method of Szabo et al. . Briefly, the pathologic changes of H. pylori infection: inflammatory cells infiltration, erosive lesions, ulceration, dysplasia, and adenoma formation (precancerous lesion).…”

Blood-Boosting and Gastro-protective influences of Diets Supplemented with Ganoderma lucidum on Indomethacin Gastric Ulcer Induced Rats

“…Thirty-five (35) healthy male Wistar rats (100-110 g) used in this study were procured from the Animal House, College of Medicine, University of Ibadan, Nigeria.…”

Protective effects of α‐bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol‐induced myocardial infarction: In vivo and in vitro evidences

“…α‐Bisabolol is a sesquiterpene alcohol found in essential oils derived from a variety of plants, including Chamomile ( Chamomilla recutita L.), Salvia ( Salvia runcinata ), Plinia cerrocampanensi , and wood of Candeia ( Eremanthus erythropappus ) . α‐Bisabolol has been shown to possess antioxidant, anti‐inflammatory, gastroprotective, antimutagenic and antibiotic, and antispasmodic properties. Apart from its medicinal properties, it has also received attention in the cosmetic and food industry due to its aroma, flavor, and additive properties.…”