Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminata Teles Freire leaves on experimental ulcer models

Viana, Ana Flávia Seraine Custódio; Fernandes, Hélio B; Silva, F.V.; Oliveira, Irisdalva Sousa; Freitas, F.F.B.P.; Machado, Flávia Danniele Frota; Costa, Charllyton Luís Sena da; Arcanjo, Daniel Dias Rufino; Chaves, Mariana Helena; Oliveira, Felipe Araújo de Alcântara; Oliveira, Rita C. M.

doi:10.1016/j.jep.2013.08.047

Cited by 42 publications

(27 citation statements)

References 42 publications

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“…The presented chromatographic method was successfully applied in the simultaneous determination of 1-5 in the extracts MBCM and MLCM (Table 5). Ellagic acid (3) is the compound present in major concentrations in both extracts and the bioavonoids agathisavone (4) and amentoavone (5) were detected only on leaves which is in accordance with the literature, since 4 and 5 were isolated only from the leaves of C. macrophyllum, 7,11 whereas ellagic acid was isolated from both leaves and stem bark 3,7 and, this is the rst report of gallic acid and methyl gallate in the stem bark of this species. In the previous work 11 from stem bark from a specimen collected in different habitat was isolated bergenin as the main compound of this species.…”

Section: Resultssupporting

confidence: 87%

Evaluation of anti-inflammatory, antinociceptive and biological activities of Cenostigma macrophyllum standardized extracts and determination and quantification of the main metabolites

et al. 2019

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The stem barks and leaves of Cenostigma macrophyllum are used in Brazilian folk medicines in the treatment of stomach and intestinal diseases. However, there are no reports of chromatographic methods used to evaluate the bioactives of its standardized extracts and for biological evaluation. An analytical method was developed and validated for simultaneous determination and quantification of the bioactive phenolics gallic acid, methyl gallate, ellagic acid and, the biflavonoids agathisflavone and amentoflavone in the leaves and stem bark of C. macrophyllum. HPLC operating conditions were optimized and the parameters such as selectivity, linearity, precision, accuracy, LOD, LOQ and, robustness of the method were also evaluated. Robustness was evaluated using a multivariate optimization technique. Linear relationships within the range of investigated concentrations were observed with their correlation coefficients greater than 0.9991. The method was validated for repeatability (RSD # 2.88%), intermediate precision (RSD # 3.38%) with recovery between 84.12 and 106.64% and the RSD less than 3.40% and proved to be robust. Besides, antioxidant, acetylcholinesterase inhibition, anti-inflammatory and antinociceptive activities of the standardized hydromethanolic extracts of leaves and stem bark of this species were evaluated. The method was successfully applied in the quantification of the gallic acid, methyl gallate, ellagic acid, agathisflavone and amentoflavone of standardized extracts. The results showed the present method developed was simple, sensitive, reproducible, accurate and precise. The standardized hydromethanolic extracts of leaves and stem bark of C. macrophyllum showed antioxidant activity (EC 50 69.09 and 83.06 mg mL À1 ), acetylcholinesterase inhibition (52.23 and 83.36%) and they were able to inhibit the formalin-induced nociception and also reduced the edema formations at 100 mg kg À1 doses. The anti-inflammatory potentials were evaluated by the decrease of the Cg-induced neutrophils migrations at the same doses. View Article Onlinea RT ¼ retention times in minutes. b In the regression equation y ¼ ax + b, x refers to the concentration (mg mL À1 ) and y is the peak area. c R 2 is the correlation coefficient of the equation. d LOD is the limit of detection. LOQ is the limit of quantication.41258 | RSC Adv., 2019,9,[41256][41257][41258][41259][41260][41261][41262][41263][41264][41265][41266][41267][41268] This journal is View Article Online a The analyzes were performed in triplicate, for each level of concentration and the results expressed as mean. b Recoveries of compounds 1-3 were determined in MBCM extracts, while the recoveries of compounds 4 and 5 were measured in MBCM extracts.41260 | RSC Adv., 2019,9,[41256][41257][41258][41259][41260][41261][41262][41263][41264][41265][41266][41267][41268] This journal is

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Section: Resultssupporting

confidence: 87%

Evaluation of anti-inflammatory, antinociceptive and biological activities of Cenostigma macrophyllum standardized extracts and determination and quantification of the main metabolites

et al. 2019

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“…Gastroprotective activity of hydroalcoholic leaf extract of Cenostigma macrophyllum against indomethacin-, cold stress-, ischemia-and ethanol-induced gastric damage has been evaluated in rats and mice (Viana et al, 2013). The hydroalcoholic leaf extract of C. macrophyllum was used at two different doses (100 and 200 mg/kg).…”

Section: Cenostigma Macrophyllummentioning

confidence: 99%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.</p><p> </p>

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“…The gastric ulcer is characterized by the reduction in blood flow, infiltration of neutrophils, induction of oxidative stress and secretion of inflammatory cytokines [2,3]. Various factors including helicobacter pyloriinfection, alcohol consumption, smoking, excessive use of non-steroidal anti-inflammatory drugs (NSAIDs), psychological and physiological stress contribute to gastric ulcer [4].…”

Section: Introductionmentioning

confidence: 99%

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Zhao

Gong

Wang

et al. 2015

International Immunopharmacology

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Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminata Teles Freire leaves on experimental ulcer models

Abstract: This study corroborates the folk medicine use of Cenostigma macrophyllum for treatment of gastric ulcers, as well as reinforces this species as a valuable source of promising natural drugs with gastroprotective activity.

Cited by 42 publications

References 42 publications

Evaluation of anti-inflammatory, antinociceptive and biological activities of Cenostigma macrophyllum standardized extracts and determination and quantification of the main metabolites

Evaluation of anti-inflammatory, antinociceptive and biological activities of Cenostigma macrophyllum standardized extracts and determination and quantification of the main metabolites

Medicinal plants with gastroprotective potential

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

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