Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats

Yokota, Junko; Takuma, Daisuke; Hamada, Atsuhide; Onogawa, Masahide; Yoshioka, Saburo; Kusunose, Masahiko; Miyamura, Mitsuhiko; Kyotani, Shojiro; Nishioka, Yasuhiko

doi:10.1007/s11418-007-0195-y

Cited by 10 publications

(11 citation statements)

References 12 publications

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“…It is well known that the seeds of E. japonica contain a cyanide glycoside, amygdarin, that can be used as an anti-cough traditional medicine in Japan [57]. Furthermore, because anti-oxidant activity [58,59] and hepatoprotective activity [60] have been reported, the seeds are also good candidates for health food together with the leaves. …”

Section: Resultsmentioning

confidence: 99%

Bioactivities of Eriobotrya japonica (Thunb.) Lindl. Leaf and Its Triterpenes

Uto¹,

Tung²,

Nakajima³

et al. 2017

J Pharmacogn Nat Prod

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The dried leaves of Eriobotrya japonica have traditionally been widely used to treat various diseases, such as chronic bronchitis, cough, inflammation, skin disease, and diabetes. Our previous studies have reported several functions and their molecular mechanisms of E. japonica leaf extract and triterpenes contained in the extract. In this review article, we focus on the effects of E. japonica leaf extract and triterpenes on inflammatory mediators, proliferation of cancer cells, and ghrelin production. 1) The leaf extract of E. japonica suppressed inflammatory mediators including nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) production in lipopolysaccharide (LPS)-stimulated RAW264 murine macrophage cells. The anti-inflammatory properties of E. japonica leaf extract resulted from inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions through downregulation of nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinases (MAPK) phosphorylation. 2) E. japonica leaves contain triterpenes such as corosolic acid, ursolic acid, maslinic acid, and oleanolic acid. Corosolic acid exterted the strongest anti-proliferative activity in human leukemia cell lines. Moreover, corosolic acid induced apoptosis mediated by mitochondrial dysfunction and caspase activation. 3) Ghrelin is an appetite-stimulating peptide hormone with an octanoyl modification at serine 3 that is essential for its orexigenic effect. Our investigation of triterpenes from E. japonica, corosolic acid, oleanolic acid, and ursolic acid suppressed octanoylated ghrelin levels in AGS-GHRL8 cell line, which produces octanoylated ghrelin in the presence of octanoic acid, without decreasing transcript expression of ghrelin O-acyltransferase (GOAT) or furin.

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Section: Resultsmentioning

confidence: 99%

Bioactivities of Eriobotrya japonica (Thunb.) Lindl. Leaf and Its Triterpenes

Uto¹,

Tung²,

Nakajima³

et al. 2017

J Pharmacogn Nat Prod

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“…It has been reported that ESE has a variety of biological effects [5][6][7][8][9][10][11][12]. Many of these effects are considered to be related to the antioxidant actions of ESE [8].…”

Section: Discussionmentioning

confidence: 99%

“…The final yield of 70% ethanol extract was 108 g. The dried extracts were dissolved with 20 L of distilled water as a stock. The high-performance liquid chromatography (HPLC) profile of ESE was previously reported, including gallic acid and caffeine as major components [9].…”

Section: Plant Materials and Preparation Of Esementioning

confidence: 99%

“…E. japonica seeds were extracted by 70% ethanol, as reported previously [3,8,9]. Briefly, E. japonica seeds (1.0 kg) were crushed in a blender equipped with a refrigerator at 1,000 rpm and then continuously stirred by a mixer at 300 rpm for 7 days after immersion in 70% ethanol.…”

Section: Plant Materials and Preparation Of Esementioning

confidence: 99%

“…The seeds also contain unsaturated fatty acids and vegetable sterols such as b-sitosterol [3]. Some of these compounds are biologically active, exhibiting antiallergic activity [5,6], antiinflammatory and immunosuppressive effects [5,[7][8][9], hypoglycemic activity [10], and ameliorative effects on hepatopathy [11] and nephropathy [12]. These effects are mainly achieved through the antioxidative activity of compounds in the seeds [12].…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative effects of Eriobotrya japonica seed extract on cellular aging in cultured rat fibroblasts

Muramoto

Quan²,

Namba³

et al. 2010

J Nat Med

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To investigate the effects of Eriobotrya japonica seed extract (ESE) on cellular aging, intracellular calcium homeostasis in young and senescent cells was analyzed using a rat fibroblast culture as an in vitro model system and a calcium imaging technique. The application of bradykinin (BK) transiently elicited intracellular calcium ion (Ca(2+)) increased in most of the young fibroblasts, whereas these responses were scarcely observed or were significantly attenuated in senescent cells. However, the long-term treatment of senescent cells with ESE (for 7 days) dose-dependently increased the amplitude of BK-induced responses and the percentage of BK-responding cells. In particular, most senescent cells could respond to BK with long-term treatment with ESE (1.0% or 2.0%), an effect that reinstated the percentage of BK-responding cells to the same level as that in young cells. The effects of ESE on amplitude or percentage of responding cells were not observed in young cells. Moreover, the time to half decay, which was significantly longer in senescent cells than that in young cells, was shortened in senescent cells with long-term treatment with ESE. These results suggest that treatment with an adequate concentration of ESE renders BK-induced Ca(2+) dynamics in senescent cells similar to those in young cells. Therefore, ESE can retard and/or protect against cellular aging and may be useful for elucidating the antiaging processes.

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Eriobotrya japonica

Lim¹

2012

Edible Medicinal and Non-Medicinal Plants

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Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats

Cited by 10 publications

References 12 publications

Bioactivities of Eriobotrya japonica (Thunb.) Lindl. Leaf and Its Triterpenes

Bioactivities of Eriobotrya japonica (Thunb.) Lindl. Leaf and Its Triterpenes

Ameliorative effects of Eriobotrya japonica seed extract on cellular aging in cultured rat fibroblasts

Eriobotrya japonica

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