Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents

Benvenutti, Régis Carlos; Vecchia, Cristian Alex Dalla; Locateli, Gelvani; Serpa, Patrícia Zanotelli; Lutinski, Junir Antônio; Rodrigues-Junior, Sinval Adalberto; Silva, Vanessa da; Vidal-Gutiérrez, Max; Vilegas, Wagner; Somensi, Líncon Bordignon; Longo, Bruna; Knihs, Jessica Ferreira; Silva, Luísa Mota da; Andrade, Sérgio Faloni de; Junior, Walter Antônio Roman

doi:10.1016/j.jep.2019.112473

Cited by 21 publications

(11 citation statements)

References 61 publications

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“…Excessive pepsin may cause extensive mucosal damage characterized by focal areas of discontinuity in the adherent mucus gel layer, punctate ulcers, and bleeding to lumen with no signs of re-epithelialization or mucus cap formation [ 51 ]. Hydroalcoholic extract of nettle leaves ( Urera baccifera ) exhibited gastroprotective effects in an ethanol-induced gastric ulcer model and decreased pepsin activity in the gastric juice in pylorus-ligated rats, and therefore, the flavonoids diosmetin and apigenin glucuronide were presumed to play major roles [ 52 ]. Yamahara et al found that vexibinol from Sophora had anti-ulcer effects in various ulcer models, including HCl-ethanol, 0.6 N HCl, 0.2 N NaOH, absolute ethanol, and 1% NH 3 -induced gastric ulcer in Wistar rats.…”

Section: Anti-ulcer Mechanisms Of Flavonoidsmentioning

confidence: 99%

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Zhang

Lian

et al. 2020

Molecules

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Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.

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Section: Anti-ulcer Mechanisms Of Flavonoidsmentioning

confidence: 99%

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Zhang

Lian

et al. 2020

Molecules

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“…After 2 hrs of all treatments with ranitidine (group 3) and compound ST-1 (group 4 and 5), the rats were orally administrated 1 mL EtOH to induce ulceration. This analysis was conducted by several studies [30][31][32]. For the ulceration induction, the fasted rats (n = 6) were orally administrated with 1 mL EtOH (99.9% purity) [33].…”

Section: Experimental Animals Ethical Statement Ulcer Induction and Groupingmentioning

confidence: 99%

Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative

et al. 2021

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Different species belonging to the genus Nephthea (Acyonaceae) are a rich resource for bioactive secondary metabolites. The literature reveals that the gastroprotective effects of marine secondary metabolites have not been comprehensively studied in vivo. Hence, the present investigation aimed to examine and determine the anti-ulcer activity of 4α,24-dimethyl-5α-cholest-8β,18-dihydroxy,22E-en-3β-ol (ST-1) isolated from samples of a Nephthea species. This in vivo study was supported by in silico molecular docking and protein–protein interaction techniques. Oral administration of ST-1 reduced rat stomach ulcers with a concurrent increase in gastric mucosa. Molecular docking calculations against the H+/K+-ATPase transporter showed a higher binding affinity of ST-1, with a docking score value of −9.9 kcal/mol and a pKi value of 59.7 nM, compared to ranitidine (a commercial proton pump inhibitor, which gave values of −6.2 kcal/mol and 27.9 µM, respectively). The combined PEA-reactome analysis results revealed promising evidence of ST-1 potency as an anti-ulcer compound through significant modulation of the gene set controlling the PI3K signaling pathway, which subsequently plays a crucial role in signaling regarding epithelialization and tissue regeneration, tissue repairing and tissue remodeling. These results indicate a probable protective role for ST-1 against ethanol-induced gastric ulcers.

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“…While in Brazil they are used in the treatment of bladder diseases, prostate hyperplasia, and urinary tract infection. Studies have indicated antiinflammatory, analgesic, and anti-edematous effects, as well as inhibitory activity against herpes simplex type 1 (HSV-1) and type 2 (HSV-2) (Benvenutti, et al, 2019). Among plants with indication for the treatment of the nervous system, the species Psychotria carthagenensis Jacq.…”

Section: Medical Potential Of Embu-verde Epamentioning

confidence: 99%

Review of the medicinal potential of the Flora of Embu-Verde Environmental Preservation Area

Sousa

Pezuk

Grecco³

2021

RSD

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The Atlantic Forest Biome is essential for 72% of the Brazilian population, but only a small part of the population has knowledge and values this environmental heritage. This biome is under constant threat; thus, strategies and actions are needed for its preservation and conservation. The Embu-Verde Environmental Preservation Area (EPA) concentrates a big part of the remaining biodiversity of the Atlantic Forest, and because it is close to the largest urban center in the country, it is increasingly threatened. The use of plants as a medicinal tool has been explored since the beginning of mankind. In fact, many of the compounds used in the health area derive from the flora. In this context, this study aimed to identify the medicinal potential of the EPA Embu-Verde flora, from the perspective that it is necessary to know to be able to preserve. Based on previous studies registering the biodiversity of EPA Embu-Verde, all the species of flora listed were investigated to identify its medicinal potential. We show here that of the 202 native species identified in the EPA Embu-Verde, there are 35 species of 23 botanical families that presented medicinal potential. The Myrtaceae family was the most cited, and its anti-inflammatory potential was the most prominent, moreover, several other uses were reported for the remaining flora. The medicinal potential of the flora of EPA Embu-Verde is still underestimated, therefore the recognition of medicinal species by the population is important. The preservation of the flora is essential to guarantee the possibility of future bioprospecting studies that will investigate the therapeutic potential of the still unknown medicinal species.

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Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents

Cited by 21 publications

References 61 publications

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative

Review of the medicinal potential of the Flora of Embu-Verde Environmental Preservation Area

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