Gastroprotective activity of the chloroform extract of the roots from <i>Arctium lappa</i> L.

Santos, Ana Cristina dos; Baggio, Cristiane Hatsuko; Freitas, Cristina Setim; Lepieszynski, Juliana; Mayer, Bárbara; Twardowschy, André; Missau, Fabiana Cristina; Santos, Élide Pereira dos; Pizzolatti, Moacir Geraldo; Marques, Maria Consuelo Andrade

doi:10.1211/jpp.60.6.0016

Cited by 37 publications

(21 citation statements)

References 34 publications

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“…Burdock (Arctium lappa L.), a biennial plant belonging to the Compositae family, has been cultivated in Eastern Asian countries, particularly in Taiwan, China and Japan for use in cooking and in folk medicine as a diuretic, antipyretic and blood purifying agent (8-10). Pharmacologically, burdock has been identified to possess hepatoprotective (11,12), desmutagenic (13), antibacterial (14,15), gastroprotective (16,17), anti-hypoglycemic (18,19), anti-hypolipidemic (20), anti-inflammatory (21), antifatigue (22), antioxidant (10,21,23), body weight management (24) and aphrodisiac (25) activities. Therefore, burdock-containing health drinks and foods are widely consumed in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of burdock leaves on elastase and tyrosinase activity

Horng

Chiang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Burdock (Arctium lappa L.) leaves generate a considerable amount of waste following burdock root harvest in Taiwan. To increase the use of burdock leaves, the present study investigated the optimal methods for producing burdock leaf extract (BLE) with high antioxidant polyphenolic content, including drying methods and solvent extraction concentration. In addition, the elastase and tyrosinase inhibitory activity of BLE was examined. Burdock leaves were dried by four methods: Shadow drying, oven drying, sun drying and freeze-drying. The extract solution was then subjected to total polyphenol content analysis and the method that produced BLE with the highest amount of total antioxidant components was taken forward for further analysis. The 1,1-diphenyl-2-pycrylhydrazyl scavenging, antielastase and antityrosinase activity of the BLE were measured to enable the evaluation of the antioxidant and skin aging-associated enzyme inhibitory activities of BLE. The results indicated that the total polyphenolic content following extraction with ethanol (EtOH) was highest using the freeze-drying method, followed by the oven drying, shadow drying and sun drying methods. BLE yielded a higher polyphenol content and stronger antioxidant activity as the ratio of the aqueous content of the extraction solvent used increased. BLE possesses marked tyrosinase and elastase inhibitory activities, with its antielastase activity notably stronger compared with its antityrosinase activity. These results indicate that the concentration of the extraction solvent was associated with the antioxidant and skin aging-associated enzyme inhibitory activity of BLE. The reactive oxygen species scavenging theory of skin aging may explain the tyrosinase and elastase inhibitory activity of BLE.In conclusion, the optimal method for obtaining BLE with a high antioxidant polyphenolic content was freeze-drying followed by 30-50% EtOH extraction. In addition, the antielastase and antityrosinase activities of the BLE produced may be aid in the development of skincare products with antiwrinkle and skin-evening properties. IntroductionThe skin is the largest organ of the human body and has essential functions, including protecting internal organs and regulating body temperature. Collagen and elastin, which are naturally occurring structural proteins in the dermis of the skin, maintain the plumpness, flexibility and elasticity of the skin. Skin aging presents as wrinkling, roughness, dryness, decreased elasticity and uneven pigmentation (1,2). In addition to intrinsic aging, extrinsic aging caused by exposure of the skin to solar radiation is an important concern. Reactive oxygen species (ROS) caused by ultraviolet (UV) radiation are clinically associated with specific markers of photoaging, including wrinkling, and increased elastin and collagen damage (2,3). Elastase digests elastin (4,5). Pigmentary changes due to the accumulation of melanin are another major characteristic of photoaging. Tyrosinase is a key enzyme that catalyzes melanin biosynthesis in...

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of burdock leaves on elastase and tyrosinase activity

Horng

Chiang

et al. 2017

Experimental and Therapeutic Medicine

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“…– is still valued as a plant with antirheumatic, diuretic and diaphoretic effects [17, 19]. Recent studies document a gastroprotective activity [24] and hepatoprotective effects [25]. …”

Section: Introductionmentioning

confidence: 99%

Anatomy of Subterranean Organs of Medicinally Used Cardueae and Related Species and its Value for Discrimination

Fritz

Saukel²

2011

Sci. Pharm.

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Numerous species of the Asteraceae, the composites, are famous for their use in both traditional and conventional medicine. Reliable anatomical descriptions of these plants and of possible adulterations provide a basis for fast identification and cheap purity controls of respective medicinal drugs by means of light microscopy. Nevertheless, detailed comparative studies on root and rhizome anatomy of valuable as well as related inconsiderable composite plants are largely missing yet. The presented study aims to narrow this gap by performing anatomical analyses of roots and rhizomes of 16 species belonging to the tribe Cardueae, of formerly and currently used drugs as well as their near relatives as potential adulterations (Carlina acaulis L., Carlina vulgaris L., Arctium lappa L., Arctium tomentosum Mill., Carduus defloratus L., Carduus personata (L.) Jacq, Cirsium arvense (L.) Scop., Cirsium vulgare (Savi) Ten., Cirsium erisithales (Jacq.) Scop., Onopordum acanthium L., Silybum marianum (L.) Gaertn., Rhaponticum scariosum Lam., Centaurea jacea L., Centaurea scabiosa L., Centaurea cyanus L., Cnicus benedictus L.). A detailed verbal and graphical survey of the analysed anatomical features is provided. Several characters were finally extracted which allow for discrimination of the examined species and may be effectively used for drug quality controls.

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“…Coconut ( Cocos nucifera ) showed antiulcerogenic activity [413], as did Yarrow ( Achillea millefolium ) [414, 415], as well as Arctium lappa [416–418]. Schütz et al [419], H.-G. Grigoleit and P. Grigoleit [420], and You et al [421] reported that Taraxacum officinale (Dandelion) relieved oxidative stress and has gastroprotective effects and Capsella bursa-pastoris is well known for its antiinflammatory and hepatoprotective function [422–424].…”

Section: Two Decades Of Traditional Medicine Research In Northern mentioning

confidence: 99%

“…But while toxicity assays are available for many countries (e.g., Argentina [365, 633], Bahrain [634], Bangladesh [635], Brazil [329, 418, 636, 637], Canada [638], Chile [639], China [640], Cuba [641, 642], Ecuador [643], Guatemala [644–646], Honduras [647], India [648], Kenya [627, 649], Mexico [650], Nicaragua [651], Nigeria [652], Panama [653], Papua New Guinea [654], Philippines [655], Uruguay [656], and USA [657–659], no data exists on the potential toxicity of Peruvian medicinal species.…”

Section: Two Decades Of Traditional Medicine Research In Northern mentioning

confidence: 99%

The Globalization of Traditional Medicine in Northern Peru: From Shamanism to Molecules

Bussmann

2013

Evidence-Based Complementary and Alternative Medicine

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Northern Peru represents the center of the Andean “health axis,” with roots going back to traditional practices of Cupisnique culture (1000 BC). For more than a decade of research, semistructured interviews were conducted with healers, collectors, and sellers of medicinal plants. In addition, bioassays were carried out to evaluate the efficacy and toxicity of plants found. Most of the 510 species encountered were native to Peru (83%). Fifty percent of the plants used in colonial times have disappeared from the pharmacopoeia. Market vendors specialized either on common and exotic plants, plants for common ailments, and plants only used by healers or on plants with magical purposes. Over 974 preparations with up to 29 different ingredients were used to treat 164 health conditions. Almost 65% of the medicinal plants were applied in these mixtures. Antibacterial activity was confirmed in most plants used for infections. Twenty-four percent of the aqueous extracts and 76% of the ethanolic extracts showed toxicity. Traditional preparation methods take this into account when choosing the appropriate solvent for the preparation of a remedy. The increasing demand for medicinal species did not increase the cultivation of medicinal plants. Most species are wild collected, causing doubts about the sustainability of trade.

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Gastroprotective activity of the chloroform extract of the roots from Arctium lappa L.

Cited by 37 publications

References 34 publications

Inhibitory effect of burdock leaves on elastase and tyrosinase activity

Inhibitory effect of burdock leaves on elastase and tyrosinase activity

Anatomy of Subterranean Organs of Medicinally Used Cardueae and Related Species and its Value for Discrimination

The Globalization of Traditional Medicine in Northern Peru: From Shamanism to Molecules

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