Gastroprotective constituents of Salvia officinalis L.

Abstract

The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.

Influence of light intensity on growth and physiological characteristics of common sage (Salvia officinalis L.)

“…Today, it is cultivated in several countries mainly to obtain the dried leaves to be used as raw material in medicine, perfumery, food industry (Santos-Gomes et al 2002) and as ornamental garden plant (Devecchi 2006). The usefulness of sage is mostly related to the activity of several secondary metabolites, especially essential oils and phenolic compounds, which are antioxidant (Pizzale et al 2002;Santos-Gomes et al 2002), gastroprotective (Mayer et al 2009), hepatoprotective (Lima et al 2005;, antimicrobial, spasmolytic, antiviral etc. (Bozin et al 2007).…”

Atividade antiulcerogênica do extrato aquoso de Salvia officinalis L. (Lamiaceae)

“…agrava esse processo (Mizui et al, 1983). Dessa forma, as ulcerações induzidas não são inibidas por agentes que interferem na secreção de ácido, mas, por substâncias que aumentam os fatores de defesa da mucosa, como por exemplo, os antioxidantes e as prostaglandinas (Miller et al, 1979). As lesões induzidas na mucosa estomacal podem estar relacionadas à produção excessiva de radicais livres e aumento do conteúdo de peróxidos lipídicos derivados de oxigênio resultando em alterações significativas em nível celular causando danos às membranas, morte celular e erosão epitelial (La Casa et al, 2000;Birdane et al, 2007;Li et al, 2008Jung et al, 2013.…”

“…Alguns estudos têm mostrado que extratos de S. offinalis podem reduzir significativamente os níveis de glicose em ratos diabéticos (Eidi et al, 2005), potencializar a capacidade antioxidante do fígado (Lima, 2005) e apresentarem in vitro, efeitos antimutagênico (Patenkovic et al, 2009) e antiangiogênico (Keshavarz et al, 2010). A atividade gastroprotetora do extrato hidroalcoólico S. offinalis foi observada por Mayer et al (2009) e as atividades farmacológicas, provavelmente estão relacionadas com a presença de polifenóis como carnosol (Topçu, 2006), apigenina, hispidulina, ácidos caféico, rosmarínico e ursólico (Imanshahidi et al, 2006).…”

Essential Oil Composition and Anti-Inflammatory Activity of <i>Salvia officinalis</i> L (Lamiaceae) in Murin Macrophages

“…In traditional medicine, the plant has been used for various purposes such as antiinflammatory, antioxidant and treatment of gastric disorders. Moreover, sage ethanol tinctures and decoctions have long been used against inflammations of oral cavity, digestive and intestinal tracts, in gastritis and tonsillitis [2,3]. Several other important biological activities of this species such as anti-bacterial, fungistatic, virustatic, astringent, hypoglycemic, eupeptic, anti-hydrotic and cytotoxic have also been reported [4][5][6].…”