Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage

Abstract

Peptic ulcer disease is a gastrointestinal disorder defined by mucosal damage and free oxygen radicals associated with peptic ulcer and gastritis. Cinnamon is a traditional herb used for many diseases and it has also effects as an antioxidant, anti-inflammatory, antispasmodic and anti-ulcerative. Our research is based on oxidative stress and effects of Oleum cinnamomi on stomach, liver and kidney disorders induced by ethanol. In our experiment, 2-3 month old male Sprague-Dawley rats were used. One hour before the mucosal damage induced by 70 % ethanol, O. cinnamomi (2.5 ml/kg) was added into the groups. Gastric pH, analysis of gastric mucus and ulcer index were calculated from samples obtained from the stomach. Superoxide dismutase (SOD), malondialdehyde and catalase (CAT) levels were determined in stomach, liver and kidney homogenates and erythrocyte hemolysate. Histopathological examination of stomach, liver and kidney were determined with H&E staining. The non-treated ulcerative group showed higher scores than the control group which was treated with O. cinnamomi, when ulcer scores, gastric mucus and pH level of stomach are compared. Increased lipid peroxidation levels were observed in the liver, kidney and erythrocyte hemolysate. SOD activity was decreased in liver whereas increased in stomach of ethanol treated ulcerative groups. CAT levels were increased in stomach and liver of ethanol treated rats. Histopathological findings showed that ethanol treatment cause multiply organ damage such as stomach, liver and kidney injury. O. cinnamomi treatment protected these tissues from ethanol-induced damage. Consequently, the current investigation shows that O. cinnamomi has protective effects on ethanol-induced oxidative and mucosal damage.

Allantoin improves histopathological evaluations in a rat model of gastritis

“…In this study, we showed that allantoin improved gastritis, mucosal thickness, and cell numbers after ethanol-induced gastritis, decreased leukocyte, and vessel numbers and increased the PGE2 and NP-SH levels in the gastric tissue of male rats. Long-term alcohol consumption is considered to be a risk factor for peptic ulcer, and ethanol administration experimentally induces gastritis, mucosal layer hyperemia, mucosal cell loss, and leukocyte infiltration in rats (3,14,18). Our results showed that ethanol decreased the mucosal layer thickness, parietal, and mucosal cell numbers and NP-SH levels, whereas allantoin treatment increased mucosal thickness, parietal, and mucosal cell counts and NP-SH levels.…”

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

“…The imbalance between gastroduodenal mucosal defenses and counteract aggressive forces are supposed to play an important role in the causation of peptic ulcer [52,53]. Several models mimicking gastroduodenal ulcer have been developed and among these models, administration of indomethacin coupled with hypothermic and restraint stress (SGU) which acquired widespread use and is considered by some experts as the gold standard gastroduodenal ulcer animal models [54,15].…”

Efficacy and safety of Wuling San for treatment of breast-cancer-related upper extremity lymphoedema: study protocol for a pilot trial

“…In addition, aqueous extract of Alismatis rhizome has been found to promote diuresis in rats34 and to have the ability to remove urinary calculi in patients with ureter calculi 35. Cortex Cinnamomi has been found to improve renal function effectively in mice 36. Furthermore, the bioactive components or extracts of the Atractylodis macrocephalae rhizome have been reported to enhance immunity in aged rats 37.…”