Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

Pinheiro, Marcelo de Almeida; Magalhães, Rafael Matos; Torres, Danielle; Cavalcante, Rodrigo Cardoso; Mota, Francisca Sheila Xavier; Coelho, Emanuela Maria Araújo Oliveira; Moreira, Henrique Pires; Lima, Glauber Cruz; Araújo, Pâmella Cristina da Costa; Leal‐Cardoso, J. H.; Coelho‐de‐Souza, Andrelina Noronha; Diniz, Lúcio Ricardo Leite

doi:10.4103/0973-1296.149725

Cited by 53 publications

(33 citation statements)

References 37 publications

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“…LIM could neutralize stomach acid and enhance peristaltic movements, and was indicated for the treatment of heartburn and gastro-intestinal reflux disorder ( Wilkins, 2002 ; Moraes et al, 2009 ; Patrick, 2011 ). Meanwhile, α-PIN exhibits a significant inhibition of gastric mucosal lesions induced by ethanol, which might be associated, at least in part, with an increase of mucus secretion and reduction of gastric hydrogen ion secretion ( Pinheiro Mde et al, 2015 ). Long term usage of NSAID such as naproxen could cause gastric ulcer.…”

Section: Terpenoidsmentioning

confidence: 99%

Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms

et al. 2018

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Ulceration in the stomach develops in peptic ulcer disease when there is a loss of protective mucosal layers, particularly in Helicobacter pylori infection. Antibiotic therapy has failed to eradicate and impede the colonization of H. pylori. Despite given treatment, recurrent bleeding can occur and lead to death in the affected individual. The disease progression is also related to the non-steroidal inflammatory drug and stress. There are extensive research efforts to identify the gastroprotective property from various alkaloids, flavonoids, and tannins compounds from plants and marine. These natural products are believed to be safe for consumption. However, not much attention was given to summarize the carbohydrate and terpenoidal anti-ulcer compounds. Hence, this review will cover the possible mechanisms and information about acidic hydroxylans, arabinogalactan and rhamnogalacturon; and limonene, pinene, lupeol, citral, ursolic acid and nomilin to exemplify on the gastroprotective properties of polysaccharides and terpenoid, respectively, obtained from fruits. These compounds could act as a prebiotic to prevent the inhabitation of H. pylori, modulate the inflammation, suppress gastric cancer growth, and capable of stimulating the reparative mechanisms on the affected regions. Finally, this review provides the future research prospects of these natural compounds in an effort to develop new therapy for gastrointestinal tissue healing.

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Section: Terpenoidsmentioning

confidence: 99%

Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms

et al. 2018

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“…Acetic acid causes the release of endogenous mediators such as PGE2 and PGF2α, histamine, bradykinin, and serotonin and stimulates the nerve endings directly by pH reduction (1). Therefore, the effectiveness of EOPPgfl in decreasing acetic acid-induced contortions, although suggesting an involvement of primarily neural mechanisms, does not exclude a antinociceptive effect of EOPPgfl due to anti-inflammatory activity, secondary to inhibitory action on the phlogistic activity of autacoids such as histamine, serotonin, and/or prostaglandin.…”

Section: Discussionmentioning

confidence: 99%

“…For medicinal purposes, they are not usually used as essential oils but mainly as infusions, teas, and incense (1). …”

Section: Introductionmentioning

confidence: 99%

“…EO of aromatic plants from Northeast Brazil have been studied from the chemical (3,4) and pharmacologic point of view (1,3,5,6) showing great potential for therapeutic use. Northeastern flora is abundant in aromatic species, whose EO consist of a mix of compounds, mostly phenylpropanoic and terpene derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…Northeastern flora is abundant in aromatic species, whose EO consist of a mix of compounds, mostly phenylpropanoic and terpene derivatives. This chemical complexity allows EO to have several biological effects, such as antiparasitic (7), antimicrobial (8), analgesic and anti-inflammatory (9), diuretic and hypotensive (10), antimalarial (11), gastro-protector (1,6), cell excitability inhibitor (12 –14), among others.…”

Section: Introductionmentioning

confidence: 99%

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Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice

Coelho‐de‐Souza

dos-Santos

Lopes-Filho

et al. 2018

Braz J Med Biol Res

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Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently pharmacologically active, the present study aimed to evaluate the antinociceptive effect of EO from Pterodon polygalaeflorus (EOPPgfl) and its acute toxic effects. The EEOPPgfl sample, which was extracted by steam distillation of the seeds, had a yield of 2.4% of the seeds weight and had, as major constituents, beta-elemene (48.19%), trans-caryophyllene (19.51%), and epi-bicyclosesquiphellandrene (12.24%). The EOPPgfl sample showed mild acute toxicity and its calculated median lethal dose (LD50) was 3.38 g/kg. EOPPgfl (20–60 mg/kg) showed antinociceptive activity as evidenced by several tests and inhibited writhing induced by acetic acid. The maximum effect was obtained with the 30 mg/kg dose and at 60 min after its administration. EOPPgfl also decreased formalin-induced nociception, as verified by the inhibition of the first and second phase of the formalin test. At 30 mg/kg, EOPPgfl also decreased thermally stimulated nociception. Nociception may be related to inflammatory and antiedematogenic activity and at doses ranging 10–100 mg/kg, EOPPgfl blocked dextran- and carrageenan-induced edema. The results demonstrated that EOPPgfl presented, at doses approximately 100 times smaller than LD50, an antinociceptive effect that probably was due to anti-inflammatory activities.

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Chemical Diversity and α‐Glucosidase Inhibitory Activity in Needles Essential Oils of Four Pinus Species from Northwestern Himalaya, India

Maurya

Vashisath

Aggarwal

et al. 2022

Chemistry & Biodiversity

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This work describes the study of the chemical profiling and α-glucosidase inhibitory activity of essential oils (EOs) from four Pinus species (P. wallichiana, P. patula, P. roxburghii and P. gerardiana). The identification and quantification of EOs metabolites were performed by GC/MS, GC-FID and 13 C-NMR. The needles of P. wallichiana and P. gerardiana presented the highest oil yields (0.35 % and 0.36 %, respectively). Twenty-four constituents were characterized in among samples exhibiting 93.8-97.7 % of the total EOs. The components and yields of the targeted samples were varied according to the species. Major components of the oils were α-pinene (20.5-34.1 %), β-pinene (1.4-53.0 %), δ-3-carene (0.2-47.0 %), limonene (1.7-13.4 %), β-phellandrene (0.2 -23.4 %), βmyrcene (1.8-7.2 %) and α-terpinolene (0.6 -7.9 %). The extracted EOs showed strong α-glucosidase inhibitory activity, which was close to the positive control, acarbose. This study showed that the EOs of Pinus species may be used as natural antidiabetic.

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Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

Cited by 53 publications

References 37 publications

Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms

Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms

Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice

Chemical Diversity and α‐Glucosidase Inhibitory Activity in Needles Essential Oils of Four Pinus Species from Northwestern Himalaya, India

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