Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice

Abstract

The protective role for BBOH and BB affording gastroprotection against gastric damage induced by ethanol indicates that these compounds contribute for the activity of Plectranthus species. The different modes of action are probably related to differences in their chemical structure.

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

“…It's well know that peptic ulcer disease arises from the imbalance between the mucosal protective factors and the aggressive factors [ 30 ] and many gastroprotective agents were found to improve the cellular integrated work to increase mucosal resistance or to decrease the aggressive factors [ 31 ]. Nowadays, the therapeutic strategy for peptic ulcer treatment is focused on either the suppression of gastric acid secretion or the enhancement of gastro-protective factors [ 32 ].…”

The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal PlantPlumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/KATPSignaling Pathway

“…Samples of the gastric mucosa were fixed in formaldehyde (10%, v/v) and prepared in 0.01 M PBS, pH 7.2, over 24 h for histopathology procedures. Sections (5 μ m) were stained with hematoxylin-eosin to evaluate gastric mucosal injury according to the criteria of Laine and Weinstein [ 22 ], as follows: edema in the upper mucosa (0–4), hemorrhagic damage (0–4), epithelial cell loss (0–3), and the presence of inflammatory cells (0–3). Photomicrographs of sections were obtained with a Leica DM microscope equipped with a Leica DFC 280 camera (200x magnification).…”

“…Pharmacological modulation of K ATP with diazoxide (agonist) or glibenclamide (antagonist) was used to investigate the involvement of these channels in the gastroprotective effect of PrLP [ 22 ]. The animals ( n = 8 per group) were pretreated with glibenclamide (5 mg/kg, i.p.…”

Bioactive Micronutrients in Coffee: Recent Analytical Approaches for Characterization and Quantification

“…They often occur in a C-20 backbone where isoprene units combine in different forms to give an array of diterpenes such as abietane [65], cembrane [66], guanacastepene A [67], quinonoid [68], jatropha [69], and cafestol and kahweol [70] types. These and several others may be found in coffee [71], tea [72], and Salvia spp.…”