Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models

Abstract

This study evaluated the gastroprotective activity of DA-6034 against various ulcerogens including ethanol, aspirin, indomethacin, stress, and acetic acid. The basic mechanisms of DA-6034 as a defensive factor such as mucus secretion and endogenous prostaglandin E(2) synthesis were determined. Rats with gastric lesions induced by ethanol-HCl, aspirin, indomethacin, and stress that had been pretreated with DA-6034 orally showed a statistically significant decrease or decreasing tendency of the gastric lesion. In acetic acid-induced gastric lesions, repeated oral administration of DA-6034 exhibited a U-shape activity in ulcer healing, with the maximum and minimum inhibition being observed at 30 and 10 mg/kg/day, respectively. DA-6034 also increased the mucus content in the gel layer as well as endogenous prostaglandin E(2) synthesis. These results suggest that DA-6034 prevents gastric mucosal injury, and these gastroprotective activities appear to be due to the increase in the gastric defensive systems.

Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA2/5-LOX Pathway

“…However, SK-MS10 does not look to be related with PGE 2 in ethanol-induced gastric mucosa damage because a significant increase of PGE 2 was not found in the gastric tissues in spite of activation of COX-2. These results are similar to previous studies [32,33], suggesting a possibility that dominant contributor of PGE 2 level after ethanol administration might be COX-1 instead of COX-2. However, the expression of COX-1 has not been measured in the present study and further experiments are needed.…”

Gastroprotective Effect ofCochinchina momordicaSeed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model

“…Other studies about gastroprotective agent such as rebamipide, eupatilin have proposed that prostaglandin-independent mechanisms 3,11,12. Taiwan study showed that sesamol potently reduced diclofenac-induced mucosal damage, but neither increased nor maintained diclofenac-induced decreases of PGE 2 , mucus, or COX activity 35.…”

“…However, there are prostaglandin independent mechanisms including neutrophil activation,7 hypermotility,8 oxygen free radicals,9 and mucosal proinflammatory cytokines 10. In part due to increasing concern about gastrodefensive factors, gastroprotective agent such as rebamipide and eupatilin have been developed 3,11,12…”

Influence of a Specific Ginger Combination on Gastropathy Conditions in Patients with Osteoarthritis of the Knee or Hip

“…This flavonoid reliably decreased damage frequency caused by ethanol, aspirin, indomethacin, or specific stress. 16 A known PG synthesis stimulator in the stomach mucosa is the hormone gastrin, produced by G-cells. 17 In the present study, serum gastrin-17 was measured before and after the therapy in both groups.…”