Gastroretentive montmorillonite-tetracycline nanoclay for the treatment of Helicobacter pylori infection

Organo-modified bentonite for gentamicin topical application: Interlayer structure and in vivo skin permeation

“…More recently, smectites have been proposed as materials for modulating drug delivery or improving dissolution of poorly water-soluble drugs (Aguzzi et al, 2005;Iannuccelli et al, 2015;Joshi et al, 2009). Among smectites, the 2:1 layered montmorillonite is probably the most investigated clay mineral.…”

“…Montmorillonite is mainly used as auxiliary material in the pharmaceutical industry for oral or topical dosage forms, recorded in the United States, European, and British Pharmacopeias. Montmorillonite, following to its high swelling behavior, can intercalate therapeutic compounds between the layers generating a host for oral or topical drug delivery (Aguzzi et al, 2005;Bello et al, 2015;Bonina et al, 2007, p. 200;de Paiva et al, 2008;Forni et al, 1987;Iannuccelli et al, 2015;Iliescu et al, 2011;Joshi et al, 2009;Kant and Datta, 2016;Katti et al, 2010;Kim et al, 2016;Mohamed et al, 2014;Rapacz-Kmita et al, 2015). Concerning topical use, montmorillonite has beneficial effects in dermatological and cosmetic applications (geotherapy, paleotherapy) (Carretero, 2002;López-Galindo et al, 2007).…”

The Use of Some Clay Minerals as Natural Resources for Drug Carrier Applications

“…According to the British, European and United States Pharmacopeias, the use of montmorillonite is mainly as auxiliary material in the pharmaceutical industry for topical or oral dosage forms. MMT indeed, thanks to its physicochemical properties (such as high swelling ratio), can intercalate active compounds between the layers generating a host for oral or topical drug delivery [54,55,56,57,58,59,60,61,62,63,64,65,66]. For montmorillonite topical use, it possesses beneficial effects in cosmetic and dermatological applications (paleotherapy and geotherapy) [1,67].…”

Calcium montmorillonite as a potential carrier in the release of bisphosphonates

“…14,15 Clays had so far been used as a carrier for such drugs such as cyclodextrin, 5-fluorouracil, ciprofloxacin, tetracycline, 5-aminosalicylic acid and 7-azaindole which were used as antibiotics, neuroprotective drugs, anti-cancer drugs and anti-inflammatory drugs. [16][17][18][19][20] Despite so many reports on the use of this type of material as drug carriers and the continuous high interest in them, they have not yet been used as a carrier of bisphosphonates. Montmorillonite was also used as an element of composites, which was then used for controlled vaginal drug delivery and for bone tissue engineering.…”