Gastroschisis, low maternal age, and fetal morbidity outcomes

Emusu, Donath; Salihu, Hamisu M.; Aliyu, Zakari Y.; Pierre-Louis, Bosny; Druschel, Charlotte M.; Kirby, Russell S.

doi:10.1002/bdra.20206

Cited by 26 publications

(26 citation statements)

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“…The association between teenage pregnancy, smoking and the incidence of gastroschisis identified in other studies [11,18,21,23] is supported by our findings. …”

Section: Discussionsupporting

confidence: 81%

“…This observation suggests that cigarette smoking may have an even more significant role in the older maternal population. The effects of smoking on fetal growth are well described with evidence that the impact may be even greater for infants of multiparous mothers [5,10,11,21]. …”

Section: Discussionmentioning

confidence: 97%

“…Initial univariate and then multivariable analyses were performed with maternal variables chosen a priori (age <20 years, single parent status, alcohol and/or cigarette use during pregnancy, illicit drug use, cocaine use, geographic isolation, population density and median income) because of their previously demonstrated association with adverse neonatal or perinatal outcomes [5,10,11] or their association with diminished perinatal care in Canada [8]. Dependent variables included perinatal outcomes (prenatal care, caesarian section delivery, delivery at planned center and gestational age of newborn), neonatal nutritional outcomes (PN duration >30 and >60 days, and total days of PN) and neonatal clinical outcomes (GPS moderate or high score, duration of hospitalization, days of mechanical ventilation and all-cause mortality).…”

Section: Methodsmentioning

confidence: 99%

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Influence of Maternal Factors on Health Outcomes in Gastroschisis: A Canadian Population-Based Study

Brindle

Flageole²,

Wales³

2012

Neonatology

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Background: Gastroschisis is increasing in incidence worldwide. There is a need for a disease-specific, population-based approach to determining factors linked with gastroschisis and its outcome. Objectives: To examine racial, socioeconomic, health and geographic predictors of gastroschisis and its outcome in Canada. Methods: 535 cases of gastroschisis from the Canadian Pediatric Surgery Network national database were included from May 2005 to May 2010. Baseline characteristics of mothers were compared with those reported by Statistics Canada. Factors associated with adverse neonatal outcomes were examined using regression analyses. Results: Mothers of infants with gastroschisis are young, often from small communities. Smoking (37%) and illicit drug use are common in this population. Single mothers receive less perinatal care (OR 0.06; 95% CI 0.02–0.28). Geographically isolated mothers are more likely to undergo caesarian section (OR 3.84; 95% CI 1.26–11.74). Cocaine use predicts a lower odds of delivering at a planned center (OR 0.25; 95% CI 0.08–0.79), and is also associated with an increased likelihood of intestinal injury at birth (OR 6.26; 95% CI 1.52–25.72). Infants of mothers from isolated communities will spend a mean of 31.9 days longer in hospital. Aboriginal status is not independently predictive of perinatal or neonatal outcome. Conclusion: Gastroschisis in Canada occurs frequently in young mothers, aboriginals and smokers. Features associated with worse outcomes include single parent status, cocaine use and maternal hometown geographic isolation.

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“…The association between teenage pregnancy, smoking and the incidence of gastroschisis identified in other studies [11,18,21,23] is supported by our findings. …”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Maternal Factors on Health Outcomes in Gastroschisis: A Canadian Population-Based Study

Brindle

Flageole²,

Wales³

2012

Neonatology

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“…The correlation between young maternal age and gastroschisis is well known [13,17], although little is understood of its biologic origins. A recent epidemiologic study reported a correlation between young maternal age and low birth weight [18]; however, the impact of young maternal age or gestational age on surgical outcomes of gastroschisis itself has not been studied. Our study is the first to indicate a protective effect of the primigravida, which was also associated with teenaged pregnancy, on disease-related morbidity in gastroschisis.…”

Section: Discussionmentioning

confidence: 96%

Infectious complications in infants with gastroschisis: an 11-year review from a referral hospital in southern Thailand

Sangkhathat

Patrapinyokul

Chiengkriwate

et al. 2008

Journal of Pediatric Surgery

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“…The Centers for Disease Control and prevention have estimated the national prevalence for these defects to be 3.73 and 2.09 per 10,000 live birth for gastroschisis and omphalocele, respectively (2). Association with young maternal age ( < 20 yr) and environmental factors have been proposed (3,4). Khuzestan province have many oil and petrochemical complex.…”

mentioning

confidence: 99%

Omphalocele, Gastroschisis: Epidemiology, Survival, and Mortality in Imam Khomeini Hospital, Ahvaz-Iran

Askarpour

Ostadian²,

Javaherizadeh³

et al. 2012

Polish Journal of Surgery

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2Gastroschisis and omphalocele are the most common malformation of the anterior abdominal wall. the aim of the study was to determine the abdominal wall defect frequencies, survival, and mortalities in Ahvaz, Khuzestan province of Iran. Materiał and methods. All cases born with omphalocele or gastroschisis whom born in Imam Khomeini hospital, were included in this study. Duration of study was 3 years from April 2005. All patients treated at Imam Khomeini hospital in Ahwaz‚ Iran. Results. Among 15321 consecutive births ‚ 42 patients had abdominal wall deformity. Overall incidence was 27.41 per 10‚000 live births. Of all cases, 18 (42.9%) of cases were male and 24 (57.1%) were female. Of all cases, 21.7% of patients with omphalocele and 10% patients with gastroschisis had other anomalies. Of all cases, 71.8% of patients with omphalocele and 60% with gastroschisis underwent surgery. The type of anomaly (omphalocele and gastroschisis) had correlation with post operation prognosis significantly (p<0.001). Of 66.7% of patients under went surgery ‚ 46.4% with mesh and 53.6% without mesh performed. 80% of patients with omphalocele and 20% with gastroschisis were lived. Conclusions: In our study, mortality was significantly higher in cases with gastroschisis than cases with omphalocele

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Gastroschisis, low maternal age, and fetal morbidity outcomes

Abstract: Low maternal age appears to be a risk factor for low birth weight and very preterm birth among gastroschisis-affected fetuses. This information is potentially useful for planning by care providers and in counseling affected parents.

Cited by 26 publications

References 0 publications

Influence of Maternal Factors on Health Outcomes in Gastroschisis: A Canadian Population-Based Study

Influence of Maternal Factors on Health Outcomes in Gastroschisis: A Canadian Population-Based Study

Infectious complications in infants with gastroschisis: an 11-year review from a referral hospital in southern Thailand

Omphalocele, Gastroschisis: Epidemiology, Survival, and Mortality in Imam Khomeini Hospital, Ahvaz-Iran

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