GATA proteins are potential negative regulators of HDC gene expression in the gastric epithelium

Watson, Fiona; Kiernan, Rachel S.; Dimaline, R.

doi:10.1016/s0167-4781(02)00301-9

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…These reports suggest that maintenance of high level GATA-6 expression inhibits the later phase of cell differentiation, although GATA-6 is necessary for the early phase of development. In addition, GATA-4 and GATA-6 have been observed to negatively regulate HDC gene expression in gastric epithelium (23). These observations are consistent with our present data that PPARγ up-regulates the protein levels of GATA-4 and maintains high levels of GATA-6 consistent with a role for these proteins in inhibiting bone marrow cell maturation into CTMCs.…”

Section: Pparγ Ligands Inhibit the Maturation Of Mast Cells Through Usupporting

confidence: 93%

Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases

Tachibana

Wada

Katayama

et al. 2008

Allergy

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Background-Mast cells play a central role in allergic and inflammatory diseases. Several reports indicated role of peroxisome proliferator-activated receptor gamma (PPARγ) on mast cell function. However, there is no report about the role of PPARγ on differentiation of mast cells from the progenitors. In this study, we investigated the role of PPARγ in regulating bone marrowderived mast cell maturation and the therapeutic implications for mast cell-related diseases such as atopic or contact dermatitis.

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Section: Pparγ Ligands Inhibit the Maturation Of Mast Cells Through Usupporting

confidence: 93%

Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases

Tachibana

Wada

Katayama

et al. 2008

Allergy

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“…In contrast to hypoxia, no HIF‐1α stabilization was observed in AGS cells in normoxia, suggesting that this transcription factor does not modulate the constitutive levels of TFF mRNA detected in these cells. Transcription factors such as GATA‐6, present in AGS cells (Watson et al. , 2002) have been reported to activate TFF1 and TFF2 promoters and regulate the constitutive expression of these genes (Al azzeh et al.…”

Section: Discussionmentioning

confidence: 99%

Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor‐1: implications for gastric mucosal healing

Hernández

Santamatilde

McCreath

et al. 2009

British J Pharmacology

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Background and purpose:Mucosal microcirculation is compromised during gastric damage induced by non-steroidal anti-inflammatory drugs, such as aspirin. Consequently, oxygen supply to epithelial cells is decreased. The trefoil factor (TFF) peptides are involved in mechanisms of defence and repair in the gastrointestinal tract but their regulation at sites of gastric injury is unknown. Experimental approach: Hypoxia and expression of TFF genes and peptides were measured in the damaged stomach of aspirin-treated rats. In a human gastric cell line (AGS cells), the effects of hypoxia and of hypoxia inducible factor (HIF)-1 (through transient transfection of HIF-1a siRNA or over-expression of HIF-1a) on TFF gene expression were evaluated. Key results: Hypoxyprobe immunostaining, up-regulation of TFF2 (1.9-fold) and TFF3 (1.8-fold) and a non-significant increase of TFF1 (1.5-fold) mRNA were observed in the damaged stomach of aspirin-treated rats, compared with control animals. Hypoxia (3% O2, 16 h) induced mRNA for TFF1 (5.8-fold), TTF2 (9.1-fold) and TFF3 (9.3-fold) in AGS cells, an effect mediated by HIF-1, as transient transfection of HIF-1a siRNA reduced the effects of hypoxia. Over-expression of HIF-1a by transfection in non-hypoxic epithelial cells produced a similar pattern of TFF induction to that observed with hypoxia and transactivated a TFF1 reporter construct. Conclusions and implications: Hypoxia inducible factor-1 mediated the induction of TFF gene expression by hypoxia in gastric epithelial cells. Low oxygen levels and up-regulation of TFF gene expression in the damaged stomach of aspirin-treated rats suggest that hypoxia induced expression of TFF genes at sites of gastric injury.

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“…The appearance of GATA factors in neuroendocrine cell hyperplasia raises the question of whether they contribute to the progression of neuroendocrine neoplasms. Interestingly, GATA factors have been shown to downregulate HDC [ 37 ] encoding a histamine synthesizing enzyme found in both normal and, in increasing amounts, in neoplastic neuroendocrine tissues [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa

et al. 2008

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Background: Human gastrointestinal mucosa regenerates vigorously throughout life, but the factors controlling cell fate in mature mucosa are poorly understood. GATA transcription factors direct cell proliferation and differentiation in many organs, and are implicated in tumorigenesis. GATA-4 and GATA-6 are considered crucial for the formation of murine gastrointestinal mucosa, but their role in human gastrointestinal tract remains unexplored. We studied in detail the expression patterns of these two GATA factors and a GATA-6 down-stream target, Indian hedgehog (Ihh), in normal human gastrointestinal mucosa. Since these factors are considered important for proliferation and differentiation, we also explored the possible alterations in their expression in gastrointestinal neoplasias. The expression of the carcinogenesis-related protein Indian hedgehog was also investigated in comparison to GATA factors.

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GATA proteins are potential negative regulators of HDC gene expression in the gastric epithelium

Cited by 8 publications

References 18 publications

Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases

Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases

Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor‐1: implications for gastric mucosal healing

Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa

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