GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter

He, Fang; Wang, Nian; Yu, Xiaoyuan; Zheng, Yufan; Li, Qun; Chen, Qingzi; Pu, Jinding; Li, Naijian; Zou, Weifeng; Li, Bing; Ran, Pixin

doi:10.1016/j.jhazmat.2022.129459

Cited by 12 publications

(6 citation statements)

References 40 publications

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“…In order to engage in the pathogenic mechanism of COPD caused by PM air pollution, authors demonstrated that GATA3/lncRNA MHC-R may regulate the immunological activities of DCs. This finding paves the way for an early diagnosis and course of COPD treatment [ 86 ].…”

Section: Future Perspectivesmentioning

confidence: 96%

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Furci

Allegra

Tonacci

et al. 2023

Life

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Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, including tobacco smoke. Various diseases are related to specific microRNA signatures, suggesting their potential role in pathophysiological processes; considering their association with environmental pollutants, they could become novel biomarkers of exposure. Therefore, the aim of the present work is to analyse data reported in the literature on the role of environmental stressors on microRNA alterations and, in particular, to identify specific alterations that might be related to the development of airway diseases so as to propose future preventive, diagnostic, and therapeutic strategies.

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Section: Future Perspectivesmentioning

confidence: 96%

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Furci

Allegra

Tonacci

et al. 2023

Life

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“… 158 Air pollution PM regulates the immune activities of DCs via the GATA3/lncRNA MHC-R nexus, which leads to the immune dysregulation of COPD patients. 159 lncRNA NONMMUT065867, lncRNA NONMMUT064312, lncRNA NONMMUT018123 up-regulated following exposure to PM2.5. These lncRNAs might be linked to lung inflammation.…”

Section: Pm25 Induced Pathogenesis In Copdmentioning

confidence: 99%

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

Wang¹,

Li²

2023

COPD

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Chronic obstructive pulmonary disease (COPD), a heterogeneous disease, is the leading cause of death worldwide. In recent years, air pollution, especially particulate matter (PM), has been widely studied as a contributing factor to COPD. As an essential component of PM, PM2.5 is associated with COPD prevalence, morbidity, and acute exacerbations. However, the specific pathogenic mechanisms were still unclear and deserve further research. The diversity and complexity of PM2.5 components make it challenging to get its accurate effects and mechanisms for COPD. It has been determined that the most toxic PM2.5 components are metals, polycyclic aromatic hydrocarbons (PAHs), carbonaceous particles (CPs), and other organic compounds. PM2.5-induced cytokine release and oxidative stress are the main mechanisms reported leading to COPD. Nonnegligibly, the microorganism in PM 2.5 may directly cause mononuclear inflammation or break the microorganism balance contributing to the development and exacerbation of COPD. This review focuses on the pathophysiology and consequences of PM2.5 and its components on COPD.

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“…Numerous animal and human studies have shown that exposure to air pollutants, including ECs (e.g., PAHs, perfluoroalkyl sulfonate, organophosphorus ester, polybrominated diphenyl ethers [PBDEs], and paraben), can contribute to respiratory, 425 dermal, 426 cardiovascular, 427 and immune disease 428 and mortality. 429 Early exposure to these pollutants in humans tends to trigger and exacerbate multiple diseases in their later life.…”

Section: Risks Of Ecs To Planetary Healthmentioning

confidence: 99%

Emerging contaminants: A One Health perspective

Wang,

Xiang,

Sze-Yin Leung

et al. 2024

The Innovation

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GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter

Cited by 12 publications

References 40 publications

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

Emerging contaminants: A One Health perspective

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