Tunnel Field Effect Transistor (TFET) is gaining recognition and provide solution for Integrated Circuit (IC) design with low power. This is due to TFET's carrier transportation scheme, which utilizes inter-band tunneling of carriers, and its fabrication similarity to MOSFET. TFET presents itself as a widely adopted device structure that can overcome the limitations of MOSFETs. However, TFETs suffer from poor DC and Radio Frequency (RF) performance, mainlydue to minority carrier transport and physical doping, which forms an abrupt junction in nanoscale devices due to RDFs. The junction-less device structure presents a viable solution to these issues without sacrificing DC parameters, even at high-frequency. Furthermore, the nanotube structure of TFET effectively reduces the Subthreshold Swing (SS) and leakage current due to better controllability of channel. The gate-all-around structure of nanotube TFET improves the surface potential distribution over the channel region, not only enhancing the DC characteristics of TFET but also improving the high-frequency parameters. The core gate Nano Tube (NT)-TFET is a promising device structure for exploring its application in the field of biomedical science as a biosensor. The proposed core gate nanotube structure provides a larger surface area for immobilizing biomolecules in the cavity, thus improving sensitivity analysis. This work proposes the utility of a novel core gate NT-TFET as a biosensor for detecting label-free biomolecules and DNAs. In this design, the detection capability of biosensor is improved, and the detection processes are investigated by high-frequency parameters of the proposed twin cavity dual metal NT-TFET biosensor. This study demonstrates the sensitivity analysis of biosensor based on transit time and device efficiency, which are two critical high-frequency parameters. This approach results in a biosensor with a lower annealing budget, making it more cost-effective and with comparatively highersensitivity