Gated blood-pool emission tomography: A new technique for the investigation of cardiac structure and function

Underwood, S. Richard; Walton, S.; Ell, P. J.; Jarritt, P. H.; Emanuel, Richard; Swanton, R. H.

doi:10.1007/bf00251306

Cited by 18 publications

(4 citation statements)

References 6 publications

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“…Tomographic multi-gated angiography has potential in evaluating right and left ventricular volumes. Total ventricular output at equilibrium can be derived from these measurements as the product of stroke volume and heart rate [15,16,17,18,19,20,21,22,23,24]. From a clinical point of view, end-diastolic and end-systolic volumes are at least as pertinent as cardiac output, but the validation of such volume measurements is difficult because of the lack of a gold standard.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it may permit simultaneous assessment at equilibrium of the right and left ventricular ejection fractions and volumes, the regurgitant fraction and regional wall motion (including the use of phase analysis for the identification of atrio-ventricular nodal bypass tracks) [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28]. Recently, software dedicated to the segmentation of TRVG data has been developed and validated clinically, making possible the widespread use of this technique in clinical settings [29,30,31].…”

Section: Introductionmentioning

confidence: 99%

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Routine measurements of left and right ventricular output by gated blood pool emission tomography in comparison with thermodilution measurements: a preliminary study

et al. 2001

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The aim of this preliminary study was to evaluate the accuracy of left and right ventricular output computed from a semi-automatic processing of tomographic radionuclide ventriculography data (TRVG) in comparison with the conventional thermodilution method. Twenty patients with various heart diseases were prospectively included in the study. Thermodilution and TRVG acquisitions were carried out on the same day for all patients. Analysis of gated blood pool slices was performed using a watershed-based segmentation algorithm. Right and left ventricular output measured by TRVG correlated well with the measurements obtained with thermodilution (r = 0.94 and 0.91 with SEE = 0.38 and 0.46 l/min, respectively, P < 0.001). The limits of agreement for TRVG and thermodilution measurements were -0.78-1.20 l/min for the left ventricle and -0.34-1.16 l/min for the right ventricle. No significant difference was found between the results of TRVG and thermodilution with respect to left ventricular output (P = 0.09). A small but significant difference was found between right ventricular output measured by TRVG and both left ventricular output measured by TRVG (mean difference = 0.17 l/min, P = 0.04) and thermodilution-derived cardiac output (mean difference = 0.41 l/min, P = 0.0001). It is concluded that the watershed-based semi-automatic segmentation of TRVG slices provides non-invasive measurements of right and left ventricular output and stroke volumes at equilibrium, in routine clinical settings. Further studies are necessary to check whether the accuracy of these measurements is good enough to permit correct assessment of intracardiac shunts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Routine measurements of left and right ventricular output by gated blood pool emission tomography in comparison with thermodilution measurements: a preliminary study

et al. 2001

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“…Hence, let us define (6) The first monomial, is added to a polynomial function of degree to make the condition possible. If we search as the least square approximation of (5) on the vector space generated by , then the set of parameters can be computed by solving the system shown in (7) at the bottom of the next page. To satisfy the additional condition the set of parameters defining are computed by solving the modified matrix equation [shown in (8) at the bottom of the next page] instead of (7).…”

Section: ) Computing Polynomialmentioning

confidence: 99%

Automatic Generation of Noise-Free Time-Activity Curve With Gated Blood-Pool Emission Tomography Using Deformation of a Reference Curve

Kerleau

Crouzet

Ahronovitz

et al. 2004

IEEE Trans. Med. Imaging

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This paper describes a new method for assessing clinical parameters from a noisy regional time-activity curve (TAC) in tomographic gated blood-pool ventriculography. This method is based on a priori knowledge on the shape of a TAC, and shape approximation. The rejection method was used to generate different random Poisson deviates, covering standard count levels, of six representative TACs in order to test and compare the proposed method with harmonic and multiharmonic reconstruction methods. These methods were compared by evaluating four clinical parameters: time of end systole, amplitude, peak ejection and filling rates. Overall, the accuracy of assessment of these parameters was found to be better with the method described in this paper than with standard multiharmonic fits.

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“…8.1 ), and the phase image in particular continues to be of interest in assessing ventricular dysynchrony before resynchronisation pacing in patients with heart failure. This group also pioneered gated blood pool tomography [ 3 ] but with only two 100 ms frames per cardiac cycle it was not until image acquisition and processing techniques improved that it became a realistic technique as used today. The simplicity and reproducibility of RNV meant that it was the technique of choice for serial assessments of LV function in patients having cardiotoxic chemotherapy or after heart transplantation but the increasing availability of echocardiography and its lack of ionising radiation led to it effectively replacing RNV.…”

Section: Radionuclide Ventriculographymentioning

confidence: 99%

A History of Nuclear Cardiology in the UK

Underwood

2016

A History of Radionuclide Studies in the UK

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Gated blood-pool emission tomography: A new technique for the investigation of cardiac structure and function

Cited by 18 publications

References 6 publications

Routine measurements of left and right ventricular output by gated blood pool emission tomography in comparison with thermodilution measurements: a preliminary study

Routine measurements of left and right ventricular output by gated blood pool emission tomography in comparison with thermodilution measurements: a preliminary study

Automatic Generation of Noise-Free Time-Activity Curve With Gated Blood-Pool Emission Tomography Using Deformation of a Reference Curve

A History of Nuclear Cardiology in the UK

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