Let be the high-order Schrödinger operator (−Δ)2+V2, where V is a non-negative potential satisfying the reverse Hölder inequality (RHq), with q>n/2 and n≥5. In this paper, we prove that when 0<α≤2−n/q, the adapted Lipschitz spaces Λα/4 we considered are equivalent to the Lipschitz space CLα associated to the Schrödinger operator L=−Δ+V. In order to obtain this characterization, we should make use of some of the results associated to (−Δ)2. We also prove the regularity properties of fractional powers (positive and negative) of the operator , Schrödinger Riesz transforms, Bessel potentials and multipliers of the Laplace transforms type associated to the high-order Schrödinger operators.