GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2

Tsai, Ming‐Shao; Lin, Yang-Hua; Chang, Geng‐He; Hsu, Cheng‐Ming; Yeh, Reming-Albert; Shu, Li-Hsin; Cheng, Yu‐Ching; Liu, Hung-Te; Wu, Yu-Huei; Wu, Yuheng; Shen, Rou-Chen; Wu, Ching‐Yuan

doi:10.1016/j.biopha.2021.112011

Cited by 8 publications

(3 citation statements)

References 44 publications

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“…The Lambda variant carries a mutation L452Q in the RBD of the Spike protein. The L452R mutation has been reported to be associated with immune evasion and stronger cellular attachment, which can increase viral transmissibility, infectivity, and pathogenicity [41] , [42] , [43] . B.1.621 is also classified as a virus variant of “concern” by the WHO.…”

Section: Sars-cov-2mentioning

confidence: 99%

A perspective on SARS-CoV-2 virus-like particles vaccines

Gao

Xia

Liu

et al. 2023

International Immunopharmacology

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Section: Sars-cov-2mentioning

confidence: 99%

A perspective on SARS-CoV-2 virus-like particles vaccines

Gao

Xia

Liu

et al. 2023

International Immunopharmacology

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“…Moreover, several recent study on G. glabra in combination with standard therapies demonstrated significantly reduction of hospitalization rate and occurrence of COVID-19 symptoms ( Armanini et al, 2020 ; Zhong et al, 2020 ; Gajewski et al, 2021 ; Li et al, 2021a ; 2021b ). Recently, several targets have been identified with the possible interaction of medicinal plants included liquorice a hopeful therapeutic for future drug ( Bandyopadhyay et al, 2021 ; Shakhsi-Niaei et al, 2021 ; Tsai et al, 2021 ). Glycyrrhizin was studied well in past and found to be the most active molecule for inhibition of replication of the SARS-associated virus and can be utilized for treatment of SARS -associated coronavirus ( Cinatl et al, 2003 ).…”

Section: Potential Health Benefit Of G Glabra As Anti-inflammatory Antiviral and Immunomodulatory Agentsmentioning

confidence: 99%

Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight.

et al. 2022

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Background Glycyrrhiza glabra L. ( G. glabra ) commonly known as liquorice is one of the highly exploited and utilized medicinal plant of the world. Since ancient times liquorice is considered as an auspicious and valuable traditional medicine across the world for treatment of various ailments. Method Several electronic online scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, online books and reports were assessed for collecting information. All the collected information was classified into different sections to meet the objective of the paper. Results The electronic database search yielded 3908 articles from different countries. Out of them one ninety-eight articles published between 1956 and 2021 were included, corresponding to all detailed review on G. glabra and research on anti-inflammatories, antivirals and immunomodulatory through pre-clinical and clinical models. From all selective area of studies on G. glabra and its bioactive components it was established (including molecular mechanisms) as a suitable remedy as per the current requirement of pandemic situation arise through respiratory tract infection. Conclusion Different relevant studies have been thoroughly reviewed to gain an insight on utility of liquorice and its bioactive constituents for several pharmacological emphasizing anti-inflammatories, antivirals and immunomodulatory effects with special emphasized for prevention and treatment of COVID-19 infection with possible mechanism of action at molecular level. Proposed directions for future research are also outlined to encourage researchers to find out various mechanistic targets and useful value added products of liquorice in future investigations.

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“…The Oolong tea is prepared from partially oxidized leaves tossed in bamboo baskets to lightly bruise the edges making the outer part of leaves oxidized with green at center. Black tea (BT) is made from withered and fully oxidized leaves, and its preparation requires a series of fermentation (Xue et al, 2022) to oxidize the catechin of green tea leaves into theaflavins, theaflavin‐3‐gallate, theaflavin‐3′‐gallate, theaflavin‐3,3′‐digallate via dimerization (Tsai et al, 2021); while the polymerization yielded thearubigins (Chattopadhyay & Naik, 2007). Puerh tea, on the other hand, is made from fully oxidized aged leaves (Dai et al, 2017; Hilal & Engelhardt, 2007).…”

Section: Introductionmentioning

confidence: 99%

Validation of antioxidant, antiproliferative, and in vitro anti‐rheumatoid arthritis activities of epigallo‐catechin‐rich bioactive fraction from Camellia sinensis var. assamica , Assam variety white tea, and its comparative evaluation with green tea fraction

Misra

Ikbal

Bhattacharjee

et al. 2022

Journal of Food Biochemistry

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The epigallocatechin‐rich polyphenolic fraction of Assam variety white tea, traditionally used for the management of diverse inflammatory ailments and health drink, was investigated through eco‐friendly green aqueous extraction, TLC, and HPLC characterization, phytochemical screening, in vitro DPPH assay, anti‐proteinase, MTT assay on synovial fibroblast and colon cancer cells, apoptotic FACS analysis, cytokine ELISA, p‐STAT3 western blotting, and in silico docking analysis. HPLC‐TLC standardized white tea fraction (WT‐F) rendered higher extractive‐yield (21%, w/w), than green tea fraction(GT‐F) (12%, w/w). WT‐F containing flavonoids and non‐hydrolysable polyphenols showed better antioxidant activity, rather than equivalent GT‐F. WT‐F demonstrated remarkable anti‐rheumatoid‐arthritis activity via killing of synovial fibroblast cells (66.1%), downregulation of TNF‐α (93.33%), IL‐6 (87.97%), and p‐STAT3 inhibition (77.75%). Furthermore, WT‐F demonstrated better anti‐proliferative activity against colon cancer cells (HCT‐116). Collectively, our study revealed that the white tea fraction has boundless potential as anti‐rheumatoid arthritis and anti‐proliferative agent coupled with apoptotic, antioxidant anti‐proteinase, and anti‐inflammatory properties. Practical applications Our eco‐friendly extracted bioactive aqueous fraction of white tea, characterized by TLC‐HPLC study and phytochemical screening have demonstrated remarkable anti‐rheumatoid arthritis property and anti‐proliferative action on colon cancer cells including potential anti‐oxidant, anti‐inflammatory, and anti‐proteinase efficacy. The test WT‐F sample has shown impressive safety on normal mammalian cells. WT‐F has demonstrated better efficacy against rheumatoid arthritis and cancer model compared to equivalent green tea fraction. Traditionally, it is extensively used for boosting immunity, and energy, with cosmetic, and agricultural applications by the native inhabitants. So, the aqueous fraction of WT is suggested to be used as a prophylactic nutraceutical supplement and or therapeutic agent in commercial polyherbal formulation to attenuate and management of auto‐inflammatory rheumatoid arthritis and carcinogenesis of colon. It is additionally suggested to establish in vivo rheumatoid arthritis animal and clinical study to validate their pharmacokinetic stability and dose optimization coupled with anti‐inflammatory, cytotoxicity, and anti‐oxidant property.

show abstract

GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2

Cited by 8 publications

References 44 publications

A perspective on SARS-CoV-2 virus-like particles vaccines

A perspective on SARS-CoV-2 virus-like particles vaccines

Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight.

Validation of antioxidant, antiproliferative, and in vitro anti‐rheumatoid arthritis activities of epigallo‐catechin‐rich bioactive fraction from Camellia sinensis var. assamica , Assam variety white tea, and its comparative evaluation with green tea fraction

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