GC Analysis of Organic Acids and Phenols Using On-Line Methylation with Trimethylsulfonium Hydroxide and PTV Solvent Split Large Volume Injection

Zapf, Andreas; Stan, Hans‐Jürgen

doi:10.1002/(sici)1521-4168(19990201)22:2<83::aid-jhrc83>3.0.co;2-d

Cited by 26 publications

(9 citation statements)

References 11 publications

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“…Since the method was first described by Vogt et al in 1979, 5 improvements have been made over the years. Some environmental researchers have evaluated its applicability, the extent of sensitivity improvement, and the optimum operational parameters for analyzing aliphatic and aromatic hydrocarbons, 6 polychlorinated biphenyls, 7 various pesticides, 6,8-10 organic acids, 11 Internal standard solutions containing naphthalene-d8, acenaphthene-d10, phenanthrene-d10, chrysene-d12, and perylene-d12 were also purchased from Ultra Scientific. Deuterated PAHs used for field surrogates (biphenyl-d10, fluoranthene-d10, and benzo[a]pyrene-d12) and analytical surrogates (fluorene-d10, pyrene-d10, and benzo[g,h,i]perylene-d12) were purchased from Cambridge Isotopes.…”

Section: Norlock Et Almentioning

confidence: 99%

Large-Volume Injection PTV-GC-MS Analysis of Polycyclic Aromatic Hydrocarbons in Air and Sediment Samples

Norlock

Jang

Zou

et al. 2002

Journal of the Air & Waste Management Association

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For the analysis of trace organic pollutants in environmental samples using a gas chromatographic (GC) instrument, large-volume injection using the programmable temperature vaporization (PTV) technique has many advantages over the traditional split/splitless injection. By increasing the injection volume from 1 or 2 microL with a split/splitless inlet to 60 microL or higher with the PTV inlet, analytical sensitivity is greatly enhanced for analytes with low concentrations. Results obtained from optimization of instrument operational parameters for analyzing polycyclic aromatic hydrocarbons (PAHs) are reported in this paper. The laboratory method detection limits for 16 PAHs and six deuterated PAH surrogates were determined using seven replicate spike samples. The initial temperature of the inlet was found to be critical in determining the analytical sensitivity of PAHs with two or three rings due to loss of these relatively highly volatile compounds during solvent vaporization. For most PAHs, the response of the mass spectrometry detector increased proportionally as the total injected volume was increased up to 150 microL. Significant interference from rubber material of the sample vial septa was observed.

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Section: Norlock Et Almentioning

confidence: 99%

Large-Volume Injection PTV-GC-MS Analysis of Polycyclic Aromatic Hydrocarbons in Air and Sediment Samples

Norlock

Jang

Zou

et al. 2002

Journal of the Air & Waste Management Association

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“…For PTV techniques, the increase of intensity for measurement results from the increasing injection volume . Some previous studies have indicated the criteria for the selection of injection volume .…”

Section: Resultsmentioning

confidence: 99%

Determination of polychlorinated dibenzo‐p‐dioxins and polychlorinated dibenzofurans, and dioxin‐like polychlorinated biphenyls in human serum using programmable‐temperature vaporization gas chromatography with high‐resolution mass spectrometry

Zhang

Zhong

Liu

et al. 2017

J of Separation Science

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The determination of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood from a non-occupational population is essential for the investigation of adverse health effects from these pollutants. In this study, a sensitive method based on programmable-temperature vaporization with large-volume injection coupled with gas chromatography with high-resolution mass spectrometry was developed to determine these pollutants in 1-2 mL of human serum samples. Various key parameters of programmable-temperature vaporization injector, including vent temperature, vent time, vent flow, transfer temperature and transfer time were optimized by factorial design. The accuracy and precision as well as applicability were assessed by determining polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in calibration standard solutions, standard reference materials and real human serum samples from non-occupational population. The method detection limits of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls were 1.5-9.0 and 0.005-0.02 ng/kg wet weight, respectively. By comparing with typically splitless injection, the application of programmable-temperature vaporization injector could effectively lead to higher detectable rate of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in 1-2 mL of human serum samples.

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“…The direct injection of analytes and TMSH mixtures into the hot injection port of the GC has been reported (Zapf & Stan, 1999). For some weak acids deprotonation and thermally decomposition of the resulting salts after derivatization have been reported to occur simultaneously in a heated GC injector , meanwhile other authors recommend pre-heating in an oven in a closed sample vial previously to injection (Halket & Zaikin, 2004).…”

Section: Optimization Of Operational Variables Acidic Herbicide Analmentioning

confidence: 99%

Chemometric Strategies for the Extraction and Analysis Optimization of Herbicide Residues in Soil Samples

Diez¹,

Barrado²,

Rodríguez³

2011

Herbicides, Theory and Applications

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GC Analysis of Organic Acids and Phenols Using On-Line Methylation with Trimethylsulfonium Hydroxide and PTV Solvent Split Large Volume Injection

Cited by 26 publications

References 11 publications

Large-Volume Injection PTV-GC-MS Analysis of Polycyclic Aromatic Hydrocarbons in Air and Sediment Samples

Large-Volume Injection PTV-GC-MS Analysis of Polycyclic Aromatic Hydrocarbons in Air and Sediment Samples

Determination of polychlorinated dibenzo‐p‐dioxins and polychlorinated dibenzofurans, and dioxin‐like polychlorinated biphenyls in human serum using programmable‐temperature vaporization gas chromatography with high‐resolution mass spectrometry

Chemometric Strategies for the Extraction and Analysis Optimization of Herbicide Residues in Soil Samples

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