GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and <i>in-silico</i> enzymes inhibitory insights

El‐Kersh, Dina M.; Mostafa, Nada M.; Fayez, Shaimaa; Al‐Warhi, Tarfah; Abourehab, Mohammed A.S.; Eldehna, Wagdy M.; Salem, Mohamed A.

doi:10.1080/14756366.2022.2097445

Cited by 14 publications

(7 citation statements)

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“…A metabolic process in the body creates an oxidative stress state that creates free radicals that can lead to body damage if they are at risky levels [68]. Due to its high phenolic and flavonoid content, aniseed extract showed promising activity as an antioxidant agent [69,70]. According to Danilenko et al [71], aniseed polar fractions may be useful as antibiotics and antioxidants in biopharmaceuticals.…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

et al. 2023

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Aniseeds (Pimpinella anisum) have gained increasing attention for their nutritional and health benefits. Aniseed extracts are known to contain a range of compounds, including flavonoids, terpenes, and essential oils. These compounds have antimicrobial properties, meaning they can help inhibit the growth of nasty bacteria and other microbes. The purpose of this study was to determine if aniseed extracts have potential antioxidant, phytochemical, and antimicrobial properties against multidrug-resistant (MDR) bacteria. A disc diffusion test was conducted in vitro to test the aniseed methanolic extract’s antibacterial activity. The MIC, MBC, and inhibition zone diameters measure the minimum inhibitory concentration, minimum bactericidal concentration, and size of the zone developed when the extract is placed on a bacterial culture, respectively. HPLC and GC/MS are analytical techniques used for identifying the phenolics and chemical constituents in the extract. DPPH, ABTS, and iron-reducing power assays were performed to evaluate the total antioxidant capacity of the extract. Using HPLC, oxygenated monoterpenes represented the majority of the aniseed content, mainly estragole, cis-anethole, and trans-anethole at 4422.39, 3150.11, and 2312.11 (g/g), respectively. All of the examined bacteria are very sensitive to aniseed’s antibacterial effects. It is thought that aniseed’s antibacterial activity could be attributed to the presence of phenolic compounds which include catechins, methyl gallates, caffeic acid, and syringic acids. According to the GC analysis, several flavonoids were detected, including catechin, isochiapin, and trans-ferulic acid, as well as quercitin rhamnose, kaempferol-O-rutinoside, gibberellic acid, and hexadecadienoic acid. Upon quantification of the most abundant estragole, we found that estragole recovery was sufficient for proving its antimicrobial activity against MDR bacteria. Utilizing three methods, the extract demonstrated strong antioxidant activity. Aniseed extract clearly inhibited MDR bacterial isolates, indicating its potential use as an anti-virulence strategy. It is assumed that polyphenolic acids and flavonoids are responsible for this activity. Trans-anethole and estragole were aniseed chemotypes. Aniseed extracts showed higher antioxidant activity than vitamin C. Future investigations into the compatibility and synergism of aniseed phenolic compounds with commercial antibacterial treatments may also show them to be promising options.

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Section: Discussionmentioning

confidence: 99%

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

et al. 2023

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“…Um estudo in-silico revelou que o trans-anetol, o estragol e o limoneno têm potencial antioxidante devido a sua possível capacidade de inibir a tirosinase e a NAD(P)H oxidase humanas (El-Kersh et al, 2022).…”

Section: Epóxi-felandrenounclassified

“…Tabela 3 -Propriedades farmacológicas dos principais constituintes dos óleos essenciais de Pimpinella anisum L. e Foeniculum vulgare Mill. antiviral (MAHENDRA et al, 2023;EL-KERSH et al, 2022). -inflamatório, antioxidante, antinociceptivo, antifúngico, anti-hiperglicêmico (HE;HUANG, 2011;PESSOA et al, 2020;MIMICA-DUKIĆ et al, 2003;SINGH et al, 2006;ROHMAN;PUTRA, 2021).…”

Section: Esse Composto Também Apresenta Atividade Antifúngica Contra ...unclassified

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Erva doce: uma revisão sobre a composição química e a bioatividade de seus óleos essenciais

Evangelista,

Rocha,

Moreira

2024

OLEL

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As ervas Pimpinella Anisum L. e Foeniculum vulgare Mill., conhecidas como erva doce, pertencem à família Apiacea e são amplamente utilizadas como ingredientes em processos culinários, como agentes fitoterápicos e para a preparação de artigos de perfumaria. O aroma e boa parte das propriedades bioativas e do potencial toxicológico dessas ervas estão associados a componentes presentes em seus óleos essenciais. Sendo assim, essa revisão bibliográfica procurou estabelecer a composição química dos óleos essenciais dessas duas espécies de erva doce, indicando os teores, propriedades farmacológicas, sensoriais e potencial tóxico de seus principais constituintes. Essas informações foram obtidas em diferentes bases de dados disponíveis online. A parte relativa à composição desses óleos essenciais foi baseada nos dados disponíveis em onze (11) artigos publicados nos últimos doze anos.

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“…Aside from reflecting the physiological status of plants, both the yield and chemical composition of such volatile blends are largely genus- and species-dependent and carry significant information about their biosynthetic systems, which highlights the effective contribution of these compounds to plant chemotaxonomy ( Wilson et al, 1992 , Ivanova et al, 2004 , Farag, 2008 , Rzepa et al, 2009 , Mamadalieva et al, 2016 , Shi et al, 2019 , Bader et al, 2014 , Bader et al, 2022 ). The growing interest in physiological, ecological, chemical, and pharmaceutical aspects of plant volatile metabolites has also stimulated the development of multiple systems for their collection and analysis ( Viljoen et al, 2008 , El-Kersh et al, 2022 ), of which solvent extraction, steam or hydro-distillation, and headspace sampling are the most routinely used practices, typically followed by gas chromatography-mass spectrometry (GC–MS) analyses ( Tholl et al, 2006 , Naudé et al, 2016 ). Compared with conventional extraction and distillation techniques, headspace analysis provides more representative profiles of plant volatiles and is more advantageous for collecting such constituents from low-emitting species ( Tholl et al, 2006 , Naudé et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the volatile metabolites of three Chorisia species: Comparative headspace GC–MS, multivariate chemometrics, chemotaxonomic significance, and anti-SARS-CoV-2 potential

Fahim¹,

Darwish²,

Zawily³

et al. 2023

Saudi Pharmaceutical Journal

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GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights

Cited by 14 publications

References 50 publications

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

Erva doce: uma revisão sobre a composição química e a bioatividade de seus óleos essenciais

Exploring the volatile metabolites of three Chorisia species: Comparative headspace GC–MS, multivariate chemometrics, chemotaxonomic significance, and anti-SARS-CoV-2 potential

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