GC–MS Study of the formation of alkoxysilanes from a sol–gel precursor in a hydrophobic solution: A potential new route to hybrid molecular imprinted polymers

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

“…The development of alternatives to the synthesis of traditional monolithic polymers has been driven by both practical considerations, for example, ease of scale‐up, requirements for integration with other technologies, such as sensors, and for performance issues, for example, mass transfer or flow properties. Methods for preparation of discrete MIP particles, composites and molecularly imprinted polymer surfaces and fibers are areas that have been gaining in prominence over recent years and now constitute a significant portion of the original literature published in the molecular imprinting field …”

Fabrication of molecularly imprinted hybrid monoliths via a room temperature ionic liquid‐mediated nonhydrolytic sol–gel route for chiral separation of zolmitriptan by capillary electrochromatography

“…M7, M3, M8, and M9 were compared to show the effect of the content of BMIM 1 PF 6 2 (0, 40, 80, and 120 mL). Detail conditions for the preparation of monoliths M1 to M10 are summarized in Table 1. stronger carboxylic acid could cause the siloxane to lost alcohols more easily [41]. As large surface of the 28 cm capillary (375 mm od6 100 mm id) used in the present work with prepolymerization mixture in a 547C water bath benefited the homogeneous reaction, and the synergism of the free-radical copolymerization existed, the reaction time in the present NHSG process was much shorter than that reported [41].…”

“…Three kinds of carboxylic acids, namely TFMAA (pK a 2.1), cinnamic acid (pK a 4.5) and MAA (pK a 4.7), were examined as the functional monomer to interact with zolmitriptan noncovalently. These carboxylic acids also acted as the catalysts for the NHSG condensation of MPTMS to form silica-based framework [26,[38][39][40][41]. The most commonly used hydrophobic and hydrophilic RTIL, BMIM 2 were incorporated for the purpose to reduce gel shrinkage and also to act as the pore template.…”

“…The free-radical copolymerization is a faster reaction, while the so-called NHSG process is slower (approximately half of the tetramethyl orthosilicate converted to various silicate species catalyzed by MAA over about 190 h at 557C) [41]. Despite the copolymerization of different carboxylic acids and the siloxane had different reaction rate, the overall reaction time lied on the NHSG process.…”

Novel layer-by-layer assembly molecularly imprinted sol–gel sensor for selective recognition of clindamycin based on Au electrode decorated by multi-wall carbon nanotube

“…Sol-gel materials are inorganic (siloxane) based polymers formed by an acid or base catalyzed hydrolysis and condensation of a series of silane monomers with excellent physical rigidity, chemical inertness and thermal stability properties [12]. Therefore, the combination of the molecular imprinting with sol-gel technique is ideally propitious to construct electrochemical sensing devices, but suffers from some limitations including slow diffusion kinetics, long response time and low sensitivity [13][14][15]. Therefore, as a sensing material, diffusion of the analytes across the inorganic MIP film needs to be accelerated to obtain a quick response.…”