Gd(III)-Nanodiamond Conjugates for MRI Contrast Enhancement

Manus, Lisa M.; Mastarone, Daniel J.; Waters, Emily A.; Zhang, Xueqing; Schultz‐Sikma, Elise A.; MacRenaris, Keith W.; Ho, Dean; Meade, Thomas J.

doi:10.1021/nl903264h

Cited by 300 publications

(284 citation statements)

References 51 publications

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“…To fulfill these requirements, a well-known T 1 CA, Gd(III), has been incorporated into various nanomaterials, for example, silica and perfluorocarbon NPs, carbon nanotubes [58] , carbon nanodots [59] , and nanodiamonds [60] , which all exhibit a high MR contrast because of a high payload of gadolinium ions and a slow tumbling motion of the particles. For a Gd(III) complex attached to the nanodiamonds, a tenfold relaxivity increase was observed compared with the monomeric Gd(III) complex.…”

Section: T 1 Np-based Contrast Agentsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Section: T 1 Np-based Contrast Agentsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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“…One approach to achieving MRI contrast using nanodiamond is to attach a magnetic species, such as Gd(III) complexes, to the nanodiamond surface (Manus et al 2010). The presence of a paramagnetic metal shortens the longitudinal spin relaxation time (T1) of water protons in the surrounding tissue and leads to contrast in T1-weighted imaging (Caravan et al 1999).…”

Section: Detection Imaging and Tracking In Vitromentioning

confidence: 99%

“…The presence of a paramagnetic metal shortens the longitudinal spin relaxation time (T1) of water protons in the surrounding tissue and leads to contrast in T1-weighted imaging (Caravan et al 1999). This technique has recently been demonstrated to enhance MRI contrast through covalent modification of the nanodiamond surface to allow the conjugation of Gd(III) complexes (Manus et al 2010).…”

Section: Detection Imaging and Tracking In Vitromentioning

confidence: 99%

Luminescent nanodiamonds for biomedical applications

et al. 2011

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In recent years, nanodiamonds have emerged from primarily an industrial and mechanical applications base, to potentially underpinning sophisticated new technologies in biomedical and quantum science. Nanodiamonds are relatively inexpensive, biocompatible, easy to surface functionalise and optically stable. This combination of physical properties are ideally suited to biological applications, including intracellular labelling and tracking, extracellular drug delivery and adsorptive detection of bioactive molecules. Here we describe some of the methods and challenges for processing nanodiamond materials, detection schemes and some of the leading applications currently under investigation.

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confidence: 99%

Atomic and Electronic Structures of Functionalized Nanodiamond Particles

et al. 2017

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Nanodiamond particles are promising candidates in a variety of applications such as drug delivery [1], diagnostic imaging [2], photo-electrochemical CO 2 reduction [3], seeding agents for diamond film growth by chemical vapor deposition [4], and energy storage [5]. The uniformity and purity of surface functionalization is critical in dictating success or failure in these applications. However, due to the complexity of the surfaces, there is a lack of fundamental understanding of the nanodiamond surface structures. Moreover, the surface structures can change during functionalization, since the process can involve, for example, thermal oxidation or hydrogenation at high temperatures.Here we address this challenge by using the advanced imaging and spectroscopy in the TEM. We examined diamond particles synthesized using the detonation (termed detonation nanodiamond, DND) and high pressure high temperature (HPHT) processes. The former method produces particles typically less than 5 nm, while the latter produces particles from tens to hundreds of nm. A monochromated, aberration-corrected TEM (Titan, FEI Company) operated at 80 kV was used for quantitative determination of the atomic structures. A monochromated, aberration corrected dedicated STEM (Nion UltraSTEM TM 100) operated at 60 kV was used for electron energy loss spectroscopy to determine the electronic structures. The low electron beam energies minimize atomic structural damage.The benefits of monochromation and aberration-correction for imaging at 80 kV can be clearly seen in Fig. 1, where near 1 Å spatial resolution provides unambiguous experimental evidence of the surface structure. The as-synthesized detonation nanodiamond particles show fullerene-like surface structures, which is the result of surface relaxation and the small particle size (Fig. 1 (a-b)). This surface behavior is also predicted by our density functional tight-binding calculations (for nanodiamond particle with same size range observed in our experiment). Upon hydrogenation treatment, the DND surface was found to be graphitized, as evidenced by the two surface graphitic-like layers (Fig. 1(c)). Fig. 2 shows experimental carbon K-edge spectra from DND, along with calculated spectra from density functional theory [6]. We have identified the pre-edge peaks (282.5, 284.6 and 286.5 eV) that are associated with vacancies and fullerene-like curved surfaces, respectively. These findings will be compared with both the hydrogenated nanodiamonds and the HPHT nanodiamonds, where the surface structures are distinctly different. Hence this combination of HRTEM and EELS provides a viable route for revealing how surface functionalization alters the atomic and electronic structures of nanodiamonds.

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Gd(III)-Nanodiamond Conjugates for MRI Contrast Enhancement

Cited by 300 publications

References 51 publications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Luminescent nanodiamonds for biomedical applications

Atomic and Electronic Structures of Functionalized Nanodiamond Particles

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