Gd3+-functionalized near-infrared quantum dots for in vivo dual modal (fluorescence/magnetic resonance) imaging

Jin, Takashi; Yoshioka, Yoshichika; Fujii, Fumihiko; Komai, Yutaka; Seki, Junji; Seiyama, Akitoshi

doi:10.1039/b812302k

Cited by 99 publications

(69 citation statements)

References 33 publications

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“…The functions to absorb and emit light and to respond by the changes of this emission to nanoscale and molecular events can be combined with magnetic, NMR-contrasting, electron-dense and other functions 16 The chelator of Gd 3+ ions coupled to CdSeTe/CdS quantum dots (Jin et al 2008 ) 6.5 Combining Fluorescence with Magnetic, NMR Enhancing and Other Functionalities (Cheon and Lee 2008 ). Three-modal and even four-modal operating nanostructures were suggested.…”

Section: Nanocomposites With Multimodal Functionmentioning

confidence: 99%

“…6.16 . The composite structure assembling the near-IR-emitting CdSeTe/CdS quantum dots together with chelating groups hosting Gd 3+ ions was constructed (Jin et al 2008 ). In this design, reduced glutathione was used as a surface coating agent and then the coated surface was functionalized with Gd 3+ -DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) complexes.…”

Section: Fluorescent Plus Nmr-contrasting Nanocompositesmentioning

confidence: 99%

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Fluorescent Nanocomposites

Demchenko¹

2015

Introduction to Fluorescence Sensing

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In previous Chapters we discussed different properties of fl uorescence emitters in order to understand them and optimize them adapting for different sensing and imaging technologies. New unlimited possibilities are offered by composing the nanocomposites formed of different types of emitters. They display a variety of novel useful features and thus extend dramatically the information content of output data. Researcher can design them from different types of luminophores of molecular and nanoscale origin (Fig. 6.1 ), manipulating with their connection, interaction, formation of new surfaces and interfaces. Their fl uorescence response can be modulated by electronic conjugation or by excited-state resonance energy transfer and coupled with other functionalities on nanoscale level.The luminescent molecules and nanoparticles can serve as building blocks for achieving versatile functions that are not observed in separate emitters alone. These larger nanocomposites demonstrate dramatically increased brightness, the ability to

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Section: Nanocomposites With Multimodal Functionmentioning

confidence: 99%

Section: Fluorescent Plus Nmr-contrasting Nanocompositesmentioning

confidence: 99%

Fluorescent Nanocomposites

Demchenko¹

2015

Introduction to Fluorescence Sensing

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“…In order to exploit their unique optical properties for biosensing and bioimaging applications, they must be non-toxic and dispersible in aqueous biological media. Approaches to surface modification of QDs to achieve aqueous dispersibility and biocompatibility have included the adsorption of small molecules such as mercaptoacetic acid to QDs surface [38], coating the QDs with silica [39][40], or encapsulating QDs within micelles [41], liposomes [42], and amphiphilic polymers [43]. However, these methods of preparing water-dispersible QDs are complicated and time consuming.…”

Section: Biophotonicsmentioning

confidence: 99%

Aqueous phase synthesis of CdTe quantum dots for biophotonics

Yong

Law

Roy

et al. 2010

Journal of Biophotonics

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Over the past few years, CdTe quantum dots have been demonstrated as powerful probes for biophotonics applications. The aqueous phase synthesis technique remains the best approach to make high quality CdTe QDs in a single‐pot process. CdTe QDs prepared directly in the aqueous phase can have quantum yield as high as 80%. In addition, the surface of CdTe QDs prepared using the aqueous phase technique is functionalized with reactive groups that enable them to be directly conjugated with specific ligands for targeted delivery and sensing. In this contribution, we review recent progress in fabricating aqueous CdTe QDs and exploiting their optical properties in novel approaches to biomedical imaging and sensing applications. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…18 In addition to light penetration, significant background signals can be reduced upon using the NIR imaging technique. 28,29 Therefore, NIR QDs can serve as a promising optical probe for improving the sensitivity of in vivo imaging. The illustration of functional, biocompatible, high-quantum yield (QY), and photostable NIR QDs will be a crucial step in the advancement of successful in vivo luminescence imaging for biomedical diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots

Lin¹,

Wang²,

Yin³

et al. 2015

IJN

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In this paper, we demonstrate the preparation of monodispersed quantum dots (QDs) as near-infrared (NIR) optical probes for in vivo pancreatic cancer targeting and imaging. The design of these luminescent probes involves functionalizing NIR QDs with ligand mercaptosuccinic acid (MSA), which targets the tumor site by enhanced permeability and retention effect. The colloidal and optical stability of the QDs can be maintained for >1 week. In vivo optical imaging studies in nude mice bearing pancreatic tumor show that the probes accumulate at tumor sites for >2.5 hours following intravenous injection of the functionalized NIR QDs. Tumor-labeling studies showed no evidence of harmful effects on the treated animals, even at a dose as high a ~50 mg/kg. These results demonstrate that the engineered MSA-functionalized QDs can serve as a diagnostic platform for early detection of cancer, as well as in image-guided precise surgical resection of tumors.

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Gd3+-functionalized near-infrared quantum dots for in vivo dual modal (fluorescence/magnetic resonance) imaging

Abstract: Gd(3+)-functionalized near-infrared emitting quantum dots were synthesized as a dual modal contrast agent for in vivo fluorescence imaging and magnetic resonance imaging.

Cited by 99 publications

References 33 publications

Fluorescent Nanocomposites

Fluorescent Nanocomposites

Aqueous phase synthesis of CdTe quantum dots for biophotonics

Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots

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