GDF-15/MIC-1 a novel member of the TGF-ß superfamily

Strelau, Jens; Böttner, Martina; Lingor, Paul; Suter‐Crazzolara, Clemens; Galter, Dagmar; Jászai, József; Sullivan, Aideen M.; Schober, Andreas; Krieglstein, Kerstin; Unsicker, Klaus

doi:10.1007/978-3-7091-6301-6_18

Cited by 56 publications

(69 citation statements)

References 10 publications

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“…An increased expression of genes for trophic factors and growth factor receptors was also observed in CD8ϩ T cells from scleroderma patients and may contribute to the in vivo persistence of these CD8ϩ T cells. Both MIC-1 and neurotrophin-4 are neurotrophic factors (43,44,79).…”

Section: Discussionmentioning

confidence: 99%

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Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

Luzina¹,

Atamas²,

Wise³

et al. 2003

Arthritis & Rheumatism

108

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Objective. Pulmonary fibrosis is a major cause of death in scleroderma patients. Previous studies have shown an increase in CD8؉ T cells in the lungs of scleroderma patients. In the present study, we sought to determine whether activated CD8؉ T cells contribute to pulmonary fibrosis in scleroderma patients through the production and activation of profibrotic mediators.Methods. CD8؉ cells were isolated from bronchoalveolar lavage fluid obtained from 19 scleroderma patients and 7 healthy subjects. The phenotype of these cells was determined using DNA array technology. Expression of selected genes was confirmed in real-time polymerase chain reaction and enzyme-linked immunosorbent assay experiments.

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Section: Discussionmentioning

confidence: 99%

“…These included the genes for TGF␤4 (also known as endometrial bleeding-associated factor), growth differentiation factor 15 (also known as macrophage inhibitory cytokine 1 [MIC-1]), and the inhibin ␣ subunit. Expression of the MIC gene is increased by cellular activation (78), and the MIC protein can serve as a trophic factor (79).…”

mentioning

confidence: 99%

Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

Luzina¹,

Atamas²,

Wise³

et al. 2003

Arthritis & Rheumatism

108

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“…MIC-1/GDF15 is also neurotrophic, and there is direct evidence for actions of systemic MIC-1/GDF15 on the brain (Strelau et al, 2000). Systemic MIC-1/GDF15 acts on areas in the brainstem and hypothalamus to suppress appetite and, when overexpressed in conditions like cancer, causes cachexia (Breit et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Within the central nervous system (CNS), MIC-1/GDF15 is expressed by the choroid plexus and secreted into the cerebrospinal fluid. It is up-regulated as part of the antiinflammatory cytokine network within the CNS in response to injury (Schober et al, 2001), and in this role, it is directly neurotrophic and possibly neuroprotective (Strelau et al, 2000). Cerebrospinal fluid (CSF) concentrations of MIC-1/GDF15 are relatively elevated in human neuronal injury (B. J.…”

Section: Introductionmentioning

confidence: 99%

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney Memory and Aging Study

et al. 2013

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SummaryHigher levels of macrophage inhibitory cytokine-1, also known as growth differentiation factor 15 (MIC-1/GDF15), are associated with adverse health outcomes and all-cause mortality. The aim of this study was to examine the relationships between MIC-1/GDF15 serum levels and global cognition, five cognitive domains, and mild cognitive impairment (MCI), at baseline (Wave 1) and prospectively at 2 years (Wave 2), in nondemented participants aged 70-90 years. Analyses were controlled for age, sex, education, Framingham risk score, history of cerebrovascular accident, acute myocardial infarction, angina, cancer, depression, C-reactive protein, tumor necrosis factor-a, interleukins 6 and 12, and apolipoprotein e4 genotype. Higher MIC-1/GDF15 levels were significantly associated with lower global cognition at both waves. Cross-sectional associations were found between MIC-1/GDF15 and all cognitive domains in Wave 1 (all P < 0.001) and between processing speed, memory, and executive function in Wave 2 (all P < 0.001). Only a trend was found for the prospective analyses, individuals with high MIC-1/GDF15 at baseline declined in global cognition, executive function, memory, and processing speed. However, when categorizing MIC-1/ GDF15 by tertiles, prospective analyses revealed statistically significant lower memory and executive function in Wave 2 in those in the upper tertile compared with the lower tertile. Receiver operating characteristics (ROC) analysis was used to determine MIC-1/GDF15 cutoff values associated with cognitive decline and showed that a MIC-1/GDF15 level exceeding 2764 pg/ml was associated with a 20% chance of decline from normal to MCI or dementia. In summary, MIC-1/GDF15 levels are associated with cognitive performance and cognitive decline. Further research is required to determine the pathophysiology of this relationship.

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“…MIC-1, which is identical to placental transforming growth factor-β (PTGF-β), placental bone morphogenic protein (PLAB), growth differentiation factor-15 (GDF-15), prostate-derived factor (PDF), or nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), is a divergent member of the TGF-β superfamily (1,2). MIC-1 is expressed quite widely; but under resting conditions, the placenta is the only tissue that expresses large quantities of MIC-1 (2).…”

Section: Introductionmentioning

confidence: 99%

Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells

Park

Lee²,

Lee

2010

BMB Reports

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GDF-15/MIC-1 a novel member of the TGF-ß superfamily

Cited by 56 publications

References 10 publications

Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney Memory and Aging Study

Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells

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