Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways

Zhang, Changhua; Xiao, Qin; Sheng, Jing; Liu, Tongtong; Cao, Ying-qian; Xue, Yanan; Shi, Min; Cao, Zheng; Zhou, Lifen; Luo, Xi; Deng, Ke-Zhong; Chen, Chen

doi:10.1016/j.biopha.2020.110076

Cited by 29 publications

(15 citation statements)

References 75 publications

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“…The findings of this study indicated that CPA‐1 and CPB‐2 administration dose dependently offered prominent reduction in the hepatic levels of TNF‐α, IL‐6 and IL‐1β in the treated groups. This results are consistent with previous reports [47,48] …”

Section: Discussionsupporting

confidence: 94%

“…In addition, insulin resistance as experienced in obesity can also trigger the release of proinflammatory cytokines from the adipose tissues and liver. Moreover, recent studies have indicated HFD fed animal models displayed high concentrations of TNF‐α, IL‐6 and IL‐1β [28,47,48] . The elevation of pro‐inflammatory cytokines as observed in this study are known indicators of progression of non‐alcoholic fatty liver disease to severe liver damages, steatohepatitis, cirrhosis, colorectal and liver cancers [49] .…”

Section: Discussionsupporting

confidence: 60%

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Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet‐Induced Metabolic Syndrome in Rats

Zhang

Yang

et al. 2021

Chemistry & Biodiversity

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This study investigated the protective effects of two polysaccharides (CPA‐1 and CPB‐2) from Cordyceps cicadae against high fructose/high fat diet (HF/HFD) induced obesity and metabolic disorders in rats. Rats were either fed with normal diet or HF/HFD and treated with CPA‐1 and CPB‐2 (100 and 300 mg/kg) for 11 weeks. Administration of CPA‐1 and CPB‐2 significantly and dose dependently reduced body and liver weight, insulin and glucose tolerance, serum insulin and glucose levels. Furthermore, serum and hepatic lipid profiles, liver function enzymes and proinflammatory cytokines (TNF‐α, IL‐1β and IL‐6) were markedly reduced. Additionally, CPA‐1 and CPB‐2 treatment alleviated hepatic oxidative stress by reducing lipid peroxidation level (MDA) and upregulating glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD) and catalase (CAT) activities as well as ameliorated histological alterations through the reduction of hepatic lipid accumulation. These results suggested that the polysaccharides from C. cicadae showed protective effects against HF/HFD induced metabolic disturbances and may be considered as a dietary supplement for treating obesity.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 60%

Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet‐Induced Metabolic Syndrome in Rats

Zhang

Yang

et al. 2021

Chemistry & Biodiversity

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“…GQD is mainly used for the treatment of type 2 diabetes and ulcerative colitis (UC). Studies showed that PI3K/AKT/FOXO1 signaling pathway is closely related to tumor cell growth, proliferation, survival, apoptosis, metabolism, angiogenesis, invasion and metastasis, tumor resistance, and tumor immune escape [ 11 , 12 ]. However, in CRC, there are few reports on the gene regulation of ABTB1 (broad complex, tramtrack and bric a brac/poxviruses and zinc finger, BTB/POZ) by GQD based on PI3K/AKT/FOXO1 signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Mechanism of Gegen Qinlian Decoction Regulating ABTB1 Expression in Colorectal Cancer Metastasis Based on PI3K/AKT/FOXO1 Pathway

Chen

Zheng

et al. 2022

BioMed Research International

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It was to investigate the role of Gegen Qinlian decoction (GQD) in the regulation of ABTB1 gene based on PI3K/AKT/FOXO1 signaling pathway in colorectal cancer (CRC) metastasis. In this study, 10 cases of the CRC mouse model were established by inoculating CT26 cells into the spleen of mice, which were divided into the experimental group and the control group, 5 cases in each group; the control group was intragastrically administered with normal saline 0.3 mL/d, and the experimental group was intragastrically administered with GQD 0.2 mL/d at a ratio of 0.2 g medicinal materials/10 g for 10 days and sacrificed, and pathological sections were made. The expression density of signaling pathway PI3K/AKT/FOXO1 as well as gene ABTB1 was detected in the sections of the two groups, and the mechanism of action of this gene in the two groups of mice was studied. It was found that the densities of p-PI3K, p-AKT, and p-FOXO1 in the experimental group of mice were 26.55 g/cm3, 70.2 g/cm3, and 24.36 g/cm3, respectively, which were significantly increased compared with the control group, P < 0.05 ; the density of ABTB1 was 35.4 g/cm3, which was significantly increased compared with the control group, P < 0.05 ; the proliferation and migration ability of CRC cells in the experimental group were significantly decreased, P < 0.05 . GQD can promote the expression of ABTB1 by activating the PI3K/AKT/FOXO1 signaling pathway, in order to inhibit the proliferation and growth ability of CRC cells.

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“…There are more and more signaling pathways related to inflammation with GSK-3 β involvement being discovered, such as the GSK-3 β /Wnt/ β -catenin/NF- κ B axis [ 37 ] and AKT/GSK-3 β -Nrf2/NF- κ B axis [ 38 ]. With the deepening of understanding, the fact that oxidative stress and the abnormal activation of inflammation are inseparable has been widely recognized [ 39 , 40 ]. Zhang and his colleagues found that the expression levels of p-Akt, p-GSK-3 β , p-Nrf2, and HO-1 were rapidly decreased in nephrectomized rats.…”

Section: Gsk-3 β /Nf- κ B Signaling In Diabetic Wound Healingmentioning

confidence: 99%

Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction

Wang

2021

International Journal of Genomics

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Diabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear factor kappa B (NF-κB) signaling pathway, a classical pathway that triggers inflammatory response, is regulated by many regulators, such as glycogen synthase kinase 3 beta (GSK-3β). Noncoding RNAs, a large class of molecules that regulate gene expression at the posttranscriptional or posttranslational level, play an important role in various stages of wound healing, especially in the stage of inflammation. Herein, we summarized the roles of noncoding RNAs in the NF-κB/GSK-3β signaling, which might provide new ideas for the treatment of diabetic wound healing.

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Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways

Cited by 29 publications

References 75 publications

Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet‐Induced Metabolic Syndrome in Rats

Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet‐Induced Metabolic Syndrome in Rats

[Retracted] Mechanism of Gegen Qinlian Decoction Regulating ABTB1 Expression in Colorectal Cancer Metastasis Based on PI3K/AKT/FOXO1 Pathway

Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction

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