Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs

Polymeric Organo-Hydrogels: Novel Biomaterials for Medical, Pharmaceutical, and Drug Delivery Platforms

“…Intravenous administration of paclitaxel-loaded NGDs shows an anti-cancer effect against lung cancer in vivo with a significant reduction in tumor volume (p < 0.05). Paclitaxelloaded NGDs may be a promising carrier for sustained drug release and chemotherapy agents (Fardous et al, 2022). Sagiri et al (2015) used the ionotropic gelation method to synthesize organogel-entrapped core-shell (organogel-alginate) type new microparticles.…”

Development of Gelled-Oil Nanoparticles for the Encapsulation and Release of Berberine

“…20,21 Bulk organogels from LMWGs can be easily downsized to aqueous colloidal dispersions of gelled-oil nanoparticles (GNPs) via a two-step process in which emulsified oil droplets are typically generated via a hot emulsification process followed by cooling. 24−27 Although GNPs have exhibited the potential for the encapsulation, protection, and delivery of a variety of bioactives with low water solubility (i.e., nile red and efavirenz, 28 rose bengal and hypericine, 29 rhodamine 123, 30 curcumin, 31,32 curcuminaldehyde, 33 sunscreen, 34 indomethacin and ketoconazole, 35 metallophthalocyanine, 36 flurbiprofen, 37 β-carotene, 38 coumarin, 39 paclitaxel, 40,41 and doxorubicin 42 ), they are still relatively seldom used. The commercially available 12-hydroxystearic acid (HSA) is the most commonly used LMWG for GNPs, 25,28,[34][35][36][37]40,41 and thus the development of new custom LWMGs offers the opportunity to form gels with a wider variety of organic liquids 43,44 as well as introduce other interesting properties to trigger different types of stimuliresponsive systems that could enable tunable release characteristics.…”

“…24−27 Although GNPs have exhibited the potential for the encapsulation, protection, and delivery of a variety of bioactives with low water solubility (i.e., nile red and efavirenz, 28 rose bengal and hypericine, 29 rhodamine 123, 30 curcumin, 31,32 curcuminaldehyde, 33 sunscreen, 34 indomethacin and ketoconazole, 35 metallophthalocyanine, 36 flurbiprofen, 37 β-carotene, 38 coumarin, 39 paclitaxel, 40,41 and doxorubicin 42 ), they are still relatively seldom used. The commercially available 12-hydroxystearic acid (HSA) is the most commonly used LMWG for GNPs, 25,28,[34][35][36][37]40,41 and thus the development of new custom LWMGs offers the opportunity to form gels with a wider variety of organic liquids 43,44 as well as introduce other interesting properties to trigger different types of stimuliresponsive systems that could enable tunable release characteristics. 45−47 Recently, we reported a family of versatile and efficient LMWGs based on N-alkylated primary oxalamides (i.e., AOx24, Figure S1) for a variety of different organic solvents, which were also biocompatible with mouse mast cells.…”

“…Gels from low-molecular-weight gelators (LMWGs) are fascinating pseudosolid, viscoelastic soft materials with a variety of different properties , for numerous biomedical applications including drug delivery . LMWGs undergo reversible, hierarchical self-assembly to mostly form one-dimensional aggregates or nanofibers that can further entangle to form a volume spanning self-assembled fibrillar network (SAFIN). , The process can be reversibly triggered by a variety of different stimuli, but most commonly heat, and is driven by the formation of noncovalent interactions such as hydrogen bonding, π–π stacking, and van der Waals and metal–ligand interactions. , Bulk organogels from LMWGs can be easily downsized to aqueous colloidal dispersions of gelled-oil nanoparticles (GNPs) via a two-step process in which emulsified oil droplets are typically generated via a hot emulsification process followed by cooling. – Although GNPs have exhibited the potential for the encapsulation, protection, and delivery of a variety of bioactives with low water solubility (i.e., nile red and efavirenz, rose bengal and hypericine, rhodamine 123, curcumin, , curcuminaldehyde, sunscreen, indomethacin and ketoconazole, metallophthalocyanine, flurbiprofen, β-carotene, coumarin, paclitaxel, , and doxorubicin), they are still relatively seldom used. The commercially available 12-hydroxystearic acid (HSA) is the most commonly used LMWG for GNPs, ,,– ,, and thus the development of new custom LWMGs offers the opportunity to form gels with a wider variety of organic liquids , as well as introduce other interesting properties to trigger different types of stimuli-responsive systems that could enable tunable release characteristics. – …”