Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

Hakim, Luqmanul; Alias, Ekram; Makpol, Suzana; Ngah, Wan Zurinah Wan; Morad, Norhashimah; Yusof, Yasmin Anum Mohd

doi:10.7314/apjcp.2014.15.11.4651

Cited by 53 publications

(54 citation statements)

References 55 publications

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“…Another research done by a researcher called Hakim T. also supports what Tahir did conclude in his research but he found that GH enhances anti-cancer effect of 5-FU (5-flurouracill) against colorectal cancers (13,14).…”

Section: Introductionsupporting

confidence: 52%

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Awareness of Medical Students at Al-Imam University of the Medical Uses and Benefits of Honey

2017

IJSR

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Aim: To assess the knowledge of Al-Imam Mohamed Ibn Saud University, collage of medicine undergraduate students about complementary and prophet medicine in general. And the uses of honey in different medical specialty. Identifying weak areas since the complementary medicine is a block of 5 weeks length is added to the student's curriculum. To improve final outcome of the block. Prove that honey affect different aspect of health positively. Methodology: We conducted a cross sectional study were a total of 100 questioner where distributed over 100 undergraduatestudents. The undergraduate studentswere selected randomly (systemic random sampling) based on the attendance sheet of the first, second and third year in medical college in the first semester of 2013. We decided to take thirty percent of each year randomly. Repeated students were excluded from the sample and replaced by other student same method of choosing the other proved students. Result: Data were collected by a questioner filed by 100 undergraduate student from first, second and third year in collage of medicine at Al-Imam Mohammed Ibn Saud University. Collected data were analyzed later. The undergraduate students were subdivided based on their grade point average. 3-3.5/5 (10%), 3.5-4/5 (50%), 4-4.5/5 (25%) and >4.5/5 (15%). We found the 55% of the approved sample have good background about the honey usage and the benefits in different medical aspect. 40% of those who know honey benefits and medically uses use honey daily. The rest of the populations were ranging from one time per week to one time per month. Conclusion: honey has proved that if affect the health in different aspects and have proved that it can be used as an immune system builder, wound and burns healing, gastric disorders, sore throat, dental care, anti-cancer agent and weight loss diets. Since the study was done in Al-Imam Mohammed Ibn Saud University, collage of medicine. We found that more than 50 percent of the students have a fair knowledge about medical uses and benefits of honey, the higher the GPA the higher the knowledge. Also from our view as undergraduate student we see that we can improve the complementary medicine block outcome by converting most of the lecture given by doctors to seminars conducted by students to maximize the overall benefit. Conduct a problem base learning sections so the student have more chances to increase their knowledge while they are searching and reading for facts on a given subject.

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Section: Introductionsupporting

confidence: 52%

“…Tahir T. and his colleagues examined the GH on colon cancer cells and they conclude that it may be an effective chemo-preventive and therapeutic strategy for inducing death to colon cancer cells (13,14).…”

Section: Introductionmentioning

confidence: 99%

Awareness of Medical Students at Al-Imam University of the Medical Uses and Benefits of Honey

2017

IJSR

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“…Recently, several studies (Unal et al, 2013;Hakim et al, 2014) have discussed the combinational effect of 5-FU with other agents, they found that the combination chemotherapy of Gemcitabine, Folinic Acid and 5-FU has a more obvious anti-cancer effect but as well as toxicity. So the combination of a natural, low-toxicity and highefficacy agents with 5-FU may be better.…”

Section: Suppressive Effect Of Sinomenine Combined With 5-fluorouracimentioning

confidence: 99%

Suppressive Effect of Sinomenine Combined with 5-Fluorouracil on Colon Carcinoma Cell Growth

Zhang¹,

Yang²,

Wu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (16), 6737-6743 IntroductionColorectal cancer is the fourth most common cancer in the world, and significant international variations in the distribution of colorectal cancer have been observed (Center et al., 2009;Siegal et al., 2013). Meanwhile, colon cancer is more frequent than rectal cancer (Labianca et al., 2010;Di Lena et al., 2013). Recently, the main therapy on primary colon carcinoma is surgical resection, but only half of them can be cured with the rest hopeless. In addition, before the colon carcinoma was diagnosed successfully, the metastasis has already happened. For better prognosis after surgical resection or other clinical situations, chemotherapy as a relatively effective therapy is used more and more.As the first-line chemotherapeutic agent to treat colon carcinoma, 5-fluorouracil (5-FU) has past 40 years (Beretta et al., 2004). Whereas the uncontrollable toxicity and dissatisfying effective rate which around 20-35% with median overall survival no more than 1 year could not meet the needs of treatment (Wu et al., 2013;Focan et al., 2013;Ghiringhelli et al., 2013). So to seek a way such as united therapy that can improve the effective rate and decrease

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“…Combination treatment of GH and ginger extract showed synergistic effects via increasing the apoptotic rate of HCT 116 colon cancer cells and reducing the 1C 50 of GH required for inhibiting the cells growth. It also showed that cotreatment of GH with Flurouracil (5-FU) has potential anti-tumour effect against colorectal cancer cell by reducing the cell growth compared to the treatment with 5-FU alone (Hakim et al 2014).…”

Section: Anticancer Properties Of Ghmentioning

confidence: 99%

Gelam Honey: A Review of Its Antioxidant, Anti-inflammatory, Anticancer and Wound Healing Aspects

Thent¹

2016

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Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

Cited by 53 publications

References 55 publications

Awareness of Medical Students at Al-Imam University of the Medical Uses and Benefits of Honey

Awareness of Medical Students at Al-Imam University of the Medical Uses and Benefits of Honey

Suppressive Effect of Sinomenine Combined with 5-Fluorouracil on Colon Carcinoma Cell Growth

Gelam Honey: A Review of Its Antioxidant, Anti-inflammatory, Anticancer and Wound Healing Aspects

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