Gelatin-based porous silicon hydrogel composites for the controlled release of tramadol

Rocha-García, Denisse; Betancourt-Mendiola, Lourdes; Wong-Arce, Alejandra; Rosales‐Mendoza, Sergio; Reyes-Hernández, Jaime; González‐Ortega, Omar; Palestino, Gabriela

doi:10.1016/j.eurpolymj.2018.09.033

Cited by 26 publications

(14 citation statements)

References 89 publications

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“…The results in Figure 1A showed that the effects of pH on the P(NIPAM‐co‐AA)/SSA were similar to that on the P(NIPAM‐co‐AA) presented in Figure S4(a), that is, the ESR of the hydrogels increased and then decreased with increasing the pH value, indicating the essentially pH‐sensitive characteristic of the hydrogels. Besides the pH‐sensitive carboxyl groups of AA inside of the hydrogels as discussed in Section 3.2.1, this was contributed by the silanol groups (SiOH, as shown in FTIR spectrum) of SSA, which could tend to dissociate to SiO − when pH > isoelectric point = 2.2 19,35 . As mentioned in Section 3.2.1, in neutral or basic aqueous media, the carboxyl moieties of AA would deprotonate to COO − groups 11 .…”

Section: Resultsmentioning

confidence: 97%

“…This was ascribed to that the SSA or AA was added to the hydrogels to increase the content of crosslinker or monomer. Thus, it increased the degree of crosslinking density of hydrogels and led to a higher reticulated network 19,36,37 . However, with excessive SSA addition, such as NASH4.5, it can be seen that its pore structure was collapsed and tangled, implying that it was not suitable for the convenience of water absorption.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, another appropriate approach for enhancing the swelling capacity of hydrogel is to modify the hydrogel with inorganic materials, such as silicon 15,16 or silica 17,18 . It can improve the swelling performance and simultaneously increase the mechanical strength of the hydrogel 19 . It is reported that Jiang et al fabricated a dual pH and temperature‐sensitive silicon‐based copolymer by grafting AA and NIPAM brushes on its surface 20 …”

Section: Introductionmentioning

confidence: 99%

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Synthesis of dual pH‐ and temperature‐sensitive poly(N‐isopropylacrylamide‐co‐acrylic acid)/sewage sludge ash hydrogel with the simultaneously high performance of swelling and deswelling

Pan

Huang

Guo

et al. 2021

Polymers for Advanced Techs

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An advanced dual pH‐ and temperature‐sensitive hydrogel (NASH2.5) was optimally synthesized through modification of N‐isopropylacrylamide (NIPAM) hydrogel with introducing 5 mol% acrylic acid (AA) and 2.5 wt% sewage sludge ash (SSA). The swelling kinetic results showed that NASH2.5 exhibited both high equilibrium swelling ratio and swelling rate, which was attributed to the higher porous structure as shown in scanning electron microscope, and the more hydrogen bonding formed inside of the hydrogel as investigated in Fourier transform infrared spectrometer. In addition, its curve was better fitted to the pseudo‐second‐order model, indicating that the water absorption process was dominated by chemisorption through forming the hydrogen bonding among the water molecules and carboxyl/silanol groups of the hydrogel. Compared with the pure NIPAM hydrogel, the water transport mechanism switched from Case I diffusion to Case II diffusion by introduction of AA and further SSA. Furthermore, through the results of the deswelling kinetics in pH value change (from 9 to 4 and 2, respectively), temperature value change (from 25 to 40, 50, and 60°C, respectively), and dual pH and temperature values changes, NASH2.5 not only presented a high pH sensitivity, but also showed high sensitive to temperature by achieving high water recovery ratio in rapid dehydrated rate. Therefore, the dual stimuli‐sensitive hydrogel with the simultaneously high performance of swelling and deswelling would provide a suitable alternative for specific applications such as pollutant adsorption.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of dual pH‐ and temperature‐sensitive poly(N‐isopropylacrylamide‐co‐acrylic acid)/sewage sludge ash hydrogel with the simultaneously high performance of swelling and deswelling

Pan

Huang

Guo

et al. 2021

Polymers for Advanced Techs

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show abstract

“…This is due to their interaction with fibrinogen (isoelectric point = 5.5) especially through the electrostatic interactions (NH 3+ vs. SiO-) in the α -domain, as studied by sodium silicate polycondensation in the presence of fibrinogen [ 47 ]. Other Van der Waals interactions and H-bonds can be involved (-NH and -OH vs. Si-OH and SiO-) ( Figure 3(b) ), usually in protein-derived hydrogels depending on the pH of the medium and pKa of the amino acids [ 49 ]. The size and concentration of silica nanoparticle nuclei must be controlled for maintaining the fibrillar organization and avoid silica aggregation.…”

Section: Mechanisms Of Silica/protein and Silica/polysaccharide Interactions And Their Impacts On The Functional Properties Of The Derivementioning

confidence: 99%

“…After that, the aldehyde groups on the chemically modified silica particles condensate mainly with the primary amine groups of lysines (pka 10.3), forming an imine bond ( Figure 4(a) ). For example, they lead to a highly dense chemical gelatin crosslinked microstructure with a more elastic behavior and lower swelling volume and water desorption at a lower temperature than the gel prepared in the presence of nonmodified silicas [ 49 ]. The silica functionalized with APTES/glutaraldehyde in the form of films can also support the formation of smooth and homogenous protein monolayer.…”

Section: Mechanisms Of Silica/protein and Silica/polysaccharide Interactions And Their Impacts On The Functional Properties Of The Derivementioning

confidence: 99%

Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Mesa

Becerra

2021

International Journal of Biomaterials

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Multifunctional and biocompatible hydrogels are on the focus of wound healing treatments. Protein and polysaccharides silica hybrids are interesting wound dressing alternatives. The objective of this review is to answer questions such as why silica for wound dressings reinforcement? What are the roles and contributions of silane precursors and silica on the functional properties of hydrogel wound dressings? The effects of tailoring the porous, morphological, and chemical characteristics of synthetic silicas on the bioactivity of hybrid wound dressings hydrogels are explored in the first part of the review. This is followed by a commented review of the mechanisms of silica/protein and silica/polysaccharide interactions and their impact on the barrier, scaffold, and delivery matrix functions of the derived hydrogels. Such information has important consequences for wound healing and paves the way to multidisciplinary researches on the production, processing, and biomedical application of this kind of hybrid materials.

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Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes

Zangabad,

Vasani,

Tong

et al. 2024

Advanced Therapeutics

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GLP‐1R agonist peptides play a prominent role in the treatment of type 2 diabetes. However, these peptides often suffer from short plasma half‐life, rapid clearance, and low in vivo chemical stability; requiring higher dosages and frequent administration. Although some peptides can be modified to improve these properties, such modification may lead to lower potency and immunogenicity. Here, a subcutaneously (SC) administrable porous silicon microparticle (pSiMP) platform for the sustained release of GLP‐1R agonist peptides is reported. The proof‐of‐concept involves using FDA‐approved exenatide, a potent GLP‐1R agonist, showcasing the platform's efficacy for therapeutic GLP‐1R peptides. pSiMPs with tailored particle size, pore dimensions, and surface chemistry unlock the potential for optimized loading and release of this peptide. The positively charged pSiMPs, with a pore diameter of 8 ± 3 nm, show an impressive loading capacity of 338 ± 42 µg mg−1 (exenatide/pSiMP). This optimized pSiMP formulation demonstrates extended and sustained exenatide release over 2 weeks in a bespoke in vitro SC tissue model. Notably, the pSiMP platform shields the peptide payload from proteolysis. In a mouse model, the SC‐injected formulation exhibits sustained in vivo release of exenatide in plasma for up to 2 weeks.

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Gelatin-based porous silicon hydrogel composites for the controlled release of tramadol

Cited by 26 publications

References 89 publications

Synthesis of dual pH‐ and temperature‐sensitive poly(N‐isopropylacrylamide‐co‐acrylic acid)/sewage sludge ash hydrogel with the simultaneously high performance of swelling and deswelling

Synthesis of dual pH‐ and temperature‐sensitive poly(N‐isopropylacrylamide‐co‐acrylic acid)/sewage sludge ash hydrogel with the simultaneously high performance of swelling and deswelling

Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes

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