Gelatin methacryloyl hydrogel as an injectable scaffold with multi-therapeutic effects to promote antimicrobial disinfection and angiogenesis for regenerative endodontics

Abstract

Regenerative endodontics represents a paradigm shift in dental pulp therapy for necrotic young permanent teeth. However, there are still challenges associated with attaining maximum root canal disinfection while supporting angiogenesis...

Incorporation of Cell‐Adhesive Proteins in 3D‐Printed Lipoic Acid‐Maleic Acid‐Poly(Propylene Glycol)‐Based Tough Gel Ink for Cell‐Supportive Microenvironment

“…Particularly, both Albumin‐MPLE and Gelatin‐MPLE gel scaffolds show a statistically significant improvement in blood vessel growth compared with the control group as shown in Figure 8D, signifying that both gelatin and albumin can promote angiogenic microenvironment at the implanted sites. [ 45,46 ] These data demonstrate that the presence of protein‐based materials in MPLE gel scaffold could induce a positive effect in terms of tissue regeneration that could be potentially applicable for tissue engineering as well as drug delivery applications.…”

Electrospun nanofibers applications in caries lesions: prevention, treatment and regeneration

“…Its injectable form also presents favorable conditions for practical clinical applications. [111][112][113] In the field of dental pulp regeneration, regenerative therapy commences with seed cells and relies on both scaffold materials to provide cell growth sites, as well as bioactive molecules to modulate cell behavior. ESNs, characterized by their adjustable three-dimensional structures and drug-loading capabilities, serve as a reliable foundation for both aspects while enhancing the success of dental pulp regeneration through antimicrobial and anti-inflammatory activities.…”

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

“…Then, GelMA hydrogels were incorporated with minocycline- or clindamycin-loaded PLGA fibers after the cryo-milling step. 77 Their antimicrobial properties against pathogens associated with root canal infections ( Actinomyces naeslundii , Fusobacterium nucleatum , and Enterococcus faecalis ) were tested. Actinomyces naeslundii was affected by both hydrogel groups while Enterococcus faecalis was resistant to clindamycin-containing hydrogels.…”