Gelatin-poly (ethylene glycol) methyl ether-functionalized porous Nanosilica for efficient doxorubicin delivery

Vo, Uyen Vy; Nguyen, Cuu Khoa; Nguyen, Van Cuong; Tran, Tuong Vi; Thi, Bao Yen To; Nguyen, Dai Hai

doi:10.1007/s10965-018-1654-8

Cited by 17 publications

(9 citation statements)

References 36 publications

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“…At pH 7.4, 12.4% of DOX was released from the NPs in the first 2 h, and later there was a steady increase from 6 h (22.4%) to 36 h (32.3%). At a pH of 4.5, there was a drastic difference as approximately half of DOX was released from the formulated NPs within 6 h, and the release constantly increased until 36 h, at around 70%, thereafter remaining stable up to 96 h. These results led the group to conclude that DOX/gelatin-mPEG-PNS NPs have a high potential for effective oral delivery of DOX in cancer therapy [17]. Another group carried out a study on the loading efficiency of PNS NPs modified by gelatin, only.…”

Section: Gelatinmentioning

confidence: 99%

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Chivere

Kondiah

Choonara

et al. 2020

Cancers

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Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery is the most convenient, widely accepted and safe route. However, the oral route of chemotherapeutics to date have displayed high gastric degradation, low aqueous solubility, poor formulation stability and minimum intestinal absorption. Thus, mainstream anti-cancer drugs in current formulations are not suitable as oral chemotherapeutic formulations. The use of biopolymers such as chitosan, gelatin, hyaluronic acid and polyglutamic acid, for the synthesis of oral delivery platforms, have potential to help overcome problems associated with oral delivery of chemotherapeutics. Biopolymers have favourable stimuli-responsive properties, and thus can be used to improve oral bioavailability of anti-cancer drugs. These biopolymeric formulations can protect gastric-sensitive drugs from pH degradation, target specific binding sites for targeted absorption and consequently control drug release. In this review, the use of various biopolymers as oral drug delivery systems for chemotherapeutics will be discussed.

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Section: Gelatinmentioning

confidence: 99%

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Chivere

Kondiah

Choonara

et al. 2020

Cancers

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“…The equilibrium dialysis method, which was described previously, was used to load RhB into PNS and HMSN [1]. Briefly, solutions with either PNS or HMSN were created by adding 16 mg of the carrier into RhB solution (10 µg/mL).…”

Section: Preparation Of Rhb/pns and Rhb/hmsnmentioning

confidence: 99%

“…Various advantages of porous nanosilica (PNS), such as a large surface area, chemical and thermal stability, high biocompatibility and biodegradability, and readiness for surface functionalization, have made it an excellent nanocarrier system for drug delivery applications [1][2][3][4]. Due to the unique porous structure of the PNS nanocarriers, anticancer drugs could be effectively encapsulated, and India), respectively.…”

Section: Introductionmentioning

confidence: 99%

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

et al. 2019

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As a promising candidate for expanding the capacity of drug loading in silica nanoplatforms, hollow mesoporous silica nanoparticles (HMSNs) are gaining increasing attention. In this study, porous nanosilica (PNS) and HMSNs were prepared by the sol-gel method and template assisted method, then further used for Rhodamine (RhB) loading. To characterize the as-synthesized nanocarriers, a number of techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were employed. The size of HMSN nanoparticles in aqueous solution averaged 134.0 ± 0.3 nm, which could be adjusted by minor changes during synthesis, whereas that of PNS nanoparticles was 63.4 ± 0.6 nm. In addition, the encapsulation of RhB into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) was successful, achieving high loading efficiency (51.67% ± 0.11%). This was significantly higher than that of RhB-loaded PNS (RhB/PNS) (12.24% ± 0.24%). Similarly, RhB/HMSN also possessed a higher RhB loading content (10.44% ± 0.02%) compared to RhB/PNS (2.90% ± 0.05%). From those results, it is suggested that prepared HMSN nanocarriers may act as high-capacity carriers in drug delivery applications.

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“…Nevertheless, several studies demonstrated that such conditions can control and delay the rate of drug release. Stimuli-responsive PNS has been developed to induce the controlled drug release triggered by temperature, light, pH, redox potential, magnetic, electric and mechanical stimuli, as well as enzyme and chemical reactions [8,9]. Among different types of stimuli-responsive PNSs, redox stimulus is competitive PNS for loading drugs in the pores because it takes advantage of intracellular conditions, namely the presence of glutathione (GSH) in tumor cells that is approximately three times higher than that in normal cells.…”

Section: Introductionmentioning

confidence: 99%

Decoration of Cyclodextrin on Surface of Porous Nano Silica via Disulfide Bond for the Controlled Drug Release

Nguyen¹,

Thi²

2020

JST

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Porous nano-silica (PNS) as promising targeted drug nanocarriers has become a new area of interest in recent years due to their tunable pore sizes and large pore volumes, high chemical and thermal stability, and excellent biocompatibility. These unique structures of PNS facilitate effective protecting drugs from degradation and denaturation. However, it has certain limitations for being used in pharmaceutical such as a burst release of encapsulated drugs. In this study, the effects of grafting cyclodextrin (CD) as gatekeeper through the biodegradable disulfide bonds on doxorubicin (DOX) release was investigated. The morphology and pore channel structures of these modified PNS were assessed by transmission electron microscopy (TEM). Fourier transform infrared spectroscopy (FT-IR) was utilized to evaluate the functional groups on PNS surface. In vitro tests were conducted for the drug loading and releasing efficiency. The results demonstrated that the prepared DOX@PNS-SS-A/CD was spherical shape with an average diameter of 45 nm, drug loading efficiency of 60.52 ± 2.12%, and sustained release. More importantly, MTT assay showed that PNS-SS-A/CD was biocompatible nanocarriers. In addition, the modified PNS incorporating DOX could significantly eliminate the toxicity of free DOX. As a result, the development of PNS-SS-A/CD may offer a promising candidate for loading and sustained release of DOX in cancer therapy.

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Gelatin-poly (ethylene glycol) methyl ether-functionalized porous Nanosilica for efficient doxorubicin delivery

Cited by 17 publications

References 36 publications

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

Decoration of Cyclodextrin on Surface of Porous Nano Silica via Disulfide Bond for the Controlled Drug Release

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