Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (PNSC@APEG) was successfully prepared with spherical shape and diameter around 50 nm, determined by transmission electron microscopy (TEM). In addition, 5-FU was efficiently trapped in PNSC@APEG particles, which were around 63.4%±3.8% and was slowly released up to 3 days in phosphate buffer saline (PBS). Furthermore, the cell proliferation kit I (MTT) assay data showed that PNSC@APEG was a biocompatible nanocarrier. These results indicated that PNSC@APEG nanoparticles have a great potential as novel carriers for anticancer drug delivery.
Recent research in drug delivery, gelatin stand out from all other natural polymer by its property such as biocompatible, biodegradable, reduced immunogenicity. Modify porous nano silica (PNS) by gelatin to use for drug delivery can avoid the detection of the human immune system. In this study, the coated PNS was successfully formed with spherical shape and diameter around 70 nm determined by transmission electron microscopy (TEM). Drug loading and release behaviors of doxorubicine@PNS-gelatin, in particular, were also tested. This study is expected to improve the stability of PNS for drug delivery system in cancer therapy.
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