Supramolecular chemistry at interfaces: host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica

Abstract

Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (PNSC@APEG) was successfully prepared with spherical shape and diameter around 50 nm, determined by transmission electron microscopy (TEM). In addition, 5-FU was efficiently trapped in PNSC@APEG particles, which were around 63.4%±3.8% and was slowly released up to 3 days in phosphate buffer saline (PBS). Furthermore, the cell proliferation kit I (MTT) assay data showed that PNSC@APEG was a biocompatible nanocarrier. These results indicated that PNSC@APEG nanoparticles have a great potential as novel carriers for anticancer drug delivery.

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

“…Another strategy allowing nanocarriers formulation and drug encapsulation is based on silica [143,144] or zinc oxide [145] nanoparticles surface modification with CD and PEG macromolecules. For instance, the CD was conjugated on porous nanosilica (PNS), subsequently, the supramolecular complexation with Ada-PEG was performed along with the addition of 5-fluorouracil (5-FU).…”

“…The resulting 5-FU loaded NPs size was 50 nm and the release of the drug lasted for 3 days. However, although the nanocarrier possesses acceptable cytotoxicity against NIH3T3 cell lines, its efficiency was lower than the free drug [143]. In contrary, Nguyen et al proposed to functionalize PNS with adamantylamine (A) by disulfide bonds (PNS-SS-A) which were subsequently supramolecularly complexed with cyclodextrin-heparin-polyethylene glycol (CD-HPEG) [144].…”

pH-Responsive sulphonated mesoporous silica: a comparative drug release study

“…The peak at 1620 cm À1 is attributed to O-H bending. 42 To investigate the successful loading of PrHy-loaded KIT-6-SO 3 H and SBA-15-SO 3 H, FT-IR measurements was conducted. 43 Moreover, Fig.…”

Decoration of Cyclodextrin on Surface of Porous Nano Silica via Disulfide Bond for the Controlled Drug Release

“…Therefore, stimuliresponsive PNSs which have disulfide bonds (S-S) as redox-sensitive groups and disulfidelinked cyclodextrin (CD) as gatekeepers could be easily cleaved in the presence of GSH which makes it an attracting redox-responsive system to release drugs at the targeted tumor sites [11 -13]. The structure of PNS delivery systems, in particular, was modified to be capable of encapsulating a variety of therapeutic agents at exceptionally high loadings [14]. For instance, Abdous et al reported the redox-responsive drug delivery system using β-Cyclodextrin to block the pore entrances of PNS through a biodegradable disulfide bond to achieve controlled release of curcumin (CUR) [15].…”